PMID- 36415137
OWN - NLM
STAT- MEDLINE
DCOM- 20230424
LR  - 20230503
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 58
IP  - 5
DP  - 2023 May
TI  - HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest 
      China.
PG  - 471-476
LID - 10.1080/00365521.2022.2147801 [doi]
AB  - BACKGROUND: Celiac disease (CD) is an autoimmune small bowel disease. Genetic 
      susceptibility for CD is mainly determined by the human leukocyte antigen 
      (HLA)-DQ haplotypes. The risk of CD conferred by HLA genotypes varies 
      geographically and across populations, however, this has not yet been documented 
      in Chinese patients with CD. AIMS: To investigate the distribution of HLA-DQ and 
      the related risks of CD development in Northwest China. METHODS: A total of 75 CD 
      patients and 300 healthy individuals were genotyped for HLA-DQ using the Illumina 
      NextSeq, and the relative risks of the different genotypes were evaluated. 
      RESULTS: In total, 68.00% of CD patients and 21.00% of controls carried HLA-DQ2.5 
      heterodimers (p < 0.001). We identified four CD risk gradients. Individuals 
      carrying a double dose of DQB1*02 had the highest risk of developing CD (1:16); 
      however, with heterozygosis (DQB1*02:02/DQB1*02:01) having the highest risk 
      (1:9). HLA-DQ2.5 individuals with a single copy of HLA-DQB1*02, in either the cis 
      or trans configuration, were at a medium risk (1:38). Non-DQ2.5 carriers of DQ8 
      or DQ2.2 were at low risk, while only carriers of DQ7.5 or DQX.5 were at very low 
      risk. Patients with the HLA-DQ2.5 genotype had more severe mucosal damage 
      compared with the HLA-DQ2.5 genotype negative CD patients (70.59% vs. 41.67%, 
      p = 0.016). CONCLUSION: Genetic susceptibility to CD is highly prevalent in the 
      Northwest Chinese population and the highest risk of developing CD was associated 
      with the DQ2.5/DQ2.2 genotype. The DQ2.5 allele is involved in the severity of 
      mucosal injury.
FAU - Shi, Tian
AU  - Shi T
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Liu, Weidong
AU  - Liu W
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Li, Ting
AU  - Li T
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Liu, Huan
AU  - Liu H
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Hui, Wenjia
AU  - Hui W
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Lin, Qiang
AU  - Lin Q
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Han, Xiaojiang
AU  - Han X
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
FAU - Gao, Feng
AU  - Gao F
AUID- ORCID: 0000-0002-3320-5702
AD  - Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
AD  - Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, China.
LA  - eng
PT  - Journal Article
DEP - 20221122
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Humans
MH  - Genetic Predisposition to Disease
MH  - *Celiac Disease/complications
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - Haplotypes
MH  - *Inflammatory Bowel Diseases/complications
MH  - China/epidemiology
OTO - NOTNLM
OT  - Celiac disease
OT  - HLA typing
OT  - genetic risk
EDAT- 2022/11/24 06:00
MHDA- 2023/04/24 06:41
CRDT- 2022/11/23 01:43
PHST- 2023/04/24 06:41 [medline]
PHST- 2022/11/24 06:00 [pubmed]
PHST- 2022/11/23 01:43 [entrez]
AID - 10.1080/00365521.2022.2147801 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2023 May;58(5):471-476. doi: 
      10.1080/00365521.2022.2147801. Epub 2022 Nov 22.