PMID- 36417258
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2673-3986 (Electronic)
IS  - 2673-3986 (Linking)
VI  - 3
IP  - 2
DP  - 2022 Jun 3
TI  - Genetic Diversity and Epidemic Types of Porcine Reproductive and Respiratory 
      Syndrome (PRRS) Virus in Japan from 2018 to 2020.
PG  - 285-296
LID - 10.3390/epidemiologia3020022 [doi]
AB  - To clarify the genetic diversity of the porcine reproductive and respiratory 
      syndrome virus (PRRSV) in Japan in recent years, we determined the nucleotide 
      sequence of open reading frame 5 of 2482 PRRSV sequences obtained from samples 
      collected from pigs between January 2018 and December 2020. As a result of 
      molecular phylogenetic analysis, Cluster II represented the largest proportion 
      (44.9-50.6%) throughout the study period, followed by Cluster IV (34.0-40.8%), 
      Cluster III (7.8-12.1%), Cluster I (3.1-6.7%), and Cluster V (0.1-0.2%). The 
      relative distributions between Clusters varied between geographic regions and 
      between years: in 2018, Cluster II was the most prevalent in all regions. In 
      2019, Cluster II was dominant in the Hokkaido and Tohoku regions, while in other 
      regions Cluster IV was dominant. In 2020, Cluster IV was dominant in the 
      Kanto/Tosan and Kyushu/Okinawa regions, whilst in other regions Cluster II was 
      predominant. Compared with a previous study, the proportions of genome sequences 
      classified in Clusters II and IV significantly increased (p = 0.042 and 0.018, 
      respectively) and those classified in Cluster III significantly decreased (p < 
      0.01). The widespread use of live attenuated vaccines using strains that belong 
      to Cluster II might have accounted for these changes in the relative distribution 
      between Clusters.
FAU - Kyutoku, Fumiaki
AU  - Kyutoku F
AUID- ORCID: 0000-0002-1468-5499
AD  - Environmental Science for Sustainable Development, Graduate School of 
      Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 
      Tokyo 113-8657, Japan.
AD  - Boehringer Ingelheim Animal Health Japan Co., Ltd., 2-1-1 Osaki, Shinagawa-ku, 
      Tokyo 141-6017, Japan.
FAU - Yokoyama, Takashi
AU  - Yokoyama T
AD  - Environmental Science for Sustainable Development, Graduate School of 
      Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 
      Tokyo 113-8657, Japan.
FAU - Sugiura, Katsuaki
AU  - Sugiura K
AUID- ORCID: 0000-0002-8807-7584
AD  - Environmental Science for Sustainable Development, Graduate School of 
      Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 
      Tokyo 113-8657, Japan.
AD  - Nippon Institute for Biological Sciences, 9-222-1 Shin-machi, Ome, Tokyo 
      198-0024, Japan.
LA  - eng
GR  - BIAHJ 101521-2/Boehringer Ingelheim (Japan)/
PT  - Journal Article
DEP - 20220603
PL  - Switzerland
TA  - Epidemiologia (Basel)
JT  - Epidemiologia (Basel, Switzerland)
JID - 9918333886406676
PMC - PMC9620939
OTO - NOTNLM
OT  - genetic diversity
OT  - phylogenetic analysis
OT  - porcine reproductive and respiratory syndrome
OT  - sequence identity
COIS- All authors have no conflicts of interest related to the content of this article.
EDAT- 2022/11/24 06:00
MHDA- 2022/11/24 06:01
PMCR- 2022/06/03
CRDT- 2022/11/23 12:22
PHST- 2022/04/07 00:00 [received]
PHST- 2022/05/13 00:00 [revised]
PHST- 2022/06/01 00:00 [accepted]
PHST- 2022/11/23 12:22 [entrez]
PHST- 2022/11/24 06:00 [pubmed]
PHST- 2022/11/24 06:01 [medline]
PHST- 2022/06/03 00:00 [pmc-release]
AID - epidemiologia3020022 [pii]
AID - epidemiologia-03-00022 [pii]
AID - 10.3390/epidemiologia3020022 [doi]
PST - epublish
SO  - Epidemiologia (Basel). 2022 Jun 3;3(2):285-296. doi: 
      10.3390/epidemiologia3020022.