PMID- 36419826
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221125
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 13
DP  - 2022
TI  - Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on 
      type 2 diabetes mellitus risk: A systematic review and meta-analysis.
PG  - 959291
LID - 10.3389/fgene.2022.959291 [doi]
LID - 959291
AB  - Backgrounds: Compared with previously published meta-analyses, this is the first 
      study to investigate the combined effects of glutathione-S-transferase 
      polymorphisms (GSTM1, GSTT1 and GSTP1 IIe105Val) and type 2 diabetes mellitus 
      (T2DM) risk; moreover, the credibility of statistically significant associations 
      was assessed; furthermore, many new original studies were published. Objectives: 
      To determine the relationship between GSTM1, GSTT1, and GSTP1 polymorphisms with 
      T2DM risk. Methods: PubMed, Embase, Wanfang, and China National Knowledge 
      Infrastructure Databases were searched. We quantify the relationship using crude 
      odds ratios and their 95% confidence intervals Moreover, the Venice criteria, 
      false-positive report probability (FPRP), and Bayesian false discovery 
      probability (BFDP) were used to validate the significance of the results. 
      Results: Overall, significantly increased T2DM risk was found between individual 
      and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on T2DM risk, but, 
      combined effects of the GSTT1 and GSTP1 polymorphisms was not statistically 
      significant. GSTT1 gene polymorphism significantly increases the risk of T2DM 
      complications, while GSTM1 and GSTP1 polymorphisms had no statistical 
      significance. The GSTM1 null genotype was linked to a particularly increased risk 
      of T2DM in Caucasians; the GSTT1 null genotype was connected to a significantly 
      higher risk of T2DM in Asians and Indians; and the GSTP1 IIe105Val polymorphism 
      was related to a substantially increased T2DM risk in Indians. Moreover, the 
      GSTM1 and GSTT1 double null genotype was associated with substantially increased 
      T2DM risk in Caucasians and Indians; the combined effects of GSTM1 and GSTP1 
      polymorphisms was associated with higher T2DM risk in Caucasians. However, all 
      significant results were false when the Venice criteria, FPRP, and BFDP test were 
      used (any FPRP >0.2 and BFDP value >0.8). Conclusion: The current analysis 
      strongly suggests that the individual and combined effects of GSTM1, GSTT1 and 
      GSTP1 polymorphisms might not be connected with elevated T2DM risk.
CI  - Copyright (c) 2022 Liu, Wang, Tang, Wang, Zheng, Wei, Li and He.
FAU - Liu, Liang-Shu
AU  - Liu LS
AD  - Changzhi Medical College, Changzhi, Shanxi, China.
FAU - Wang, Di
AU  - Wang D
AD  - Changzhi Medical College, Changzhi, Shanxi, China.
FAU - Tang, Ru
AU  - Tang R
AD  - Changzhi Medical College, Changzhi, Shanxi, China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Changzhi Medical College, Changzhi, Shanxi, China.
FAU - Zheng, Lu
AU  - Zheng L
AD  - Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical 
      College, Changzhi, Shanxi, China.
FAU - Wei, Jian
AU  - Wei J
AD  - Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical 
      College, Changzhi, Shanxi, China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical 
      College, Changzhi, Shanxi, China.
FAU - He, Xiao-Feng
AU  - He XF
AD  - Department of Epidemiology, School of Public Health to Southern Medical 
      University, Guangzhou, Guangdong, China.
AD  - Institute of Evidence-Based Medicine, Heping Hospital Affiliated to Changzhi 
      Medical College, Changzhi, China.
LA  - eng
PT  - Systematic Review
DEP - 20221107
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC9676647
OTO - NOTNLM
OT  - GSTM1
OT  - GSTP1
OT  - GSTT1
OT  - T2DM
OT  - genetic polymorphism
OT  - meta-analysis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/25 06:00
MHDA- 2022/11/25 06:01
PMCR- 2022/11/07
CRDT- 2022/11/24 02:24
PHST- 2022/06/01 00:00 [received]
PHST- 2022/10/14 00:00 [accepted]
PHST- 2022/11/24 02:24 [entrez]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/25 06:01 [medline]
PHST- 2022/11/07 00:00 [pmc-release]
AID - 959291 [pii]
AID - 10.3389/fgene.2022.959291 [doi]
PST - epublish
SO  - Front Genet. 2022 Nov 7;13:959291. doi: 10.3389/fgene.2022.959291. eCollection 
      2022.