PMID- 36420642
OWN - NLM
STAT- MEDLINE
DCOM- 20230803
LR  - 20231125
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 78
IP  - 8
DP  - 2023 Aug 2
TI  - Proton Pump Inhibitor Use and Cognitive Function in the Boston Puerto Rican 
      Health Study.
PG  - 1461-1470
LID - 10.1093/gerona/glac231 [doi]
AB  - BACKGROUND: There is a lack of consensus among studies on the association between 
      proton pump inhibitor (PPI) use and cognitive impairment. This association is not 
      well studied among minority populations, including among Puerto Ricans. 
      Therefore, we sought to examine this association among Boston-area Puerto Ricans. 
      METHODS: The Boston Puerto Rican Health Study is an ongoing longitudinal cohort 
      that enrolled 1499 Boston-area Puerto Rican adults, aged 45-75 years at baseline. 
      Complete outcome and exposure data was available for 1290 baseline participants. 
      Covariate-adjusted linear regression and linear mixed effects models were used to 
      examine the association between PPI use, and global cognition, executive 
      function, and memory cross-sectionally and longitudinally over ~12.7 years of 
      follow-up. Furthermore, we examined the cross-sectional association between 
      long-term PPI use (continuous use of ~6.2 years) and global cognition, executive 
      function, and memory. RESULTS: Among 1 290 participants at baseline, 313 (24.3%) 
      self-reported PPI use. Baseline PPI use was not associated with baseline global 
      cognition, executive function, or memory. Baseline PPI use also did not alter the 
      trajectory of global cognition, executive function, or memory over ~12.7 years of 
      follow-up. Long-term PPI use was not associated with global cognition, executive 
      function, or memory over ~12.7 years of follow-up. CONCLUSION: In this study of 
      Boston-area Puerto Ricans, we did not observe an association between PPI use and 
      global cognition, executive function, or memory either cross-sectionally or over 
      12.7 years of follow-up.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Dinesh, Deepika
AU  - Dinesh D
AD  - Center for Population Health, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
AD  - Department of Biomedical and Nutritional Sciences, University of Massachusetts 
      Lowell, Lowell, Massachusetts, USA.
FAU - Lee, Jong Soo
AU  - Lee JS
AD  - Center for Population Health, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
AD  - Department of Mathematical Sciences, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
FAU - Scott, Tammy M
AU  - Scott TM
AD  - Center for Population Health, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
AD  - Friedman School of Nutrition Science and Policy, Tufts University, Boston, 
      Massachusetts, USA.
AD  - Department of Psychiatry, School of Medicine, Tufts University, Boston, 
      Massachusetts, USA.
FAU - Tucker, Katherine L
AU  - Tucker KL
AD  - Center for Population Health, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
AD  - Department of Biomedical and Nutritional Sciences, University of Massachusetts 
      Lowell, Lowell, Massachusetts, USA.
FAU - Palacios, Natalia
AU  - Palacios N
AUID- ORCID: 0000-0002-0643-7735
AD  - Center for Population Health, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
AD  - Department of Public Health, University of Massachusetts Lowell, Lowell, 
      Massachusetts, USA.
AD  - Department of Nutrition, Harvard University School of Public Health, Boston, 
      Massachusetts, USA.
AD  - Geriatric Research Education Clinical Center, Department of Veterans Affairs, 
      ENRM VA Hospital, Bedford, Massachusetts, USA.
LA  - eng
GR  - R01 NS097723/NS/NINDS NIH HHS/United States
GR  - P50 HL105185/HL/NHLBI NIH HHS/United States
GR  - P01 AG023394/AG/NIA NIH HHS/United States
GR  - R01 AG055948/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - *Proton Pump Inhibitors/adverse effects
MH  - Cross-Sectional Studies
MH  - Cognition
MH  - *Cognitive Dysfunction/chemically induced/epidemiology
MH  - Hispanic or Latino
PMC - PMC10395560
OTO - NOTNLM
OT  - Boston-area Puerto Ricans
OT  - Cognitive function
OT  - Proton pump inhibitors
COIS- None declared.
EDAT- 2022/11/25 06:00
MHDA- 2023/08/03 06:43
PMCR- 2023/11/24
CRDT- 2022/11/24 04:03
PHST- 2022/06/17 00:00 [received]
PHST- 2023/08/03 06:43 [medline]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/24 04:03 [entrez]
PHST- 2023/11/24 00:00 [pmc-release]
AID - 6844020 [pii]
AID - glac231 [pii]
AID - 10.1093/gerona/glac231 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2023 Aug 2;78(8):1461-1470. doi: 
      10.1093/gerona/glac231.