PMID- 36421565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221126
IS  - 2310-2861 (Electronic)
IS  - 2310-2861 (Linking)
VI  - 8
IP  - 11
DP  - 2022 Nov 16
TI  - Influence of Copper-Strontium Co-Doping on Bioactivity, Cytotoxicity and 
      Antibacterial Activity of Mesoporous Bioactive Glass.
LID - 10.3390/gels8110743 [doi]
LID - 743
AB  - Mesoporous bioactive glass (MBG) is an extensively studied biomaterial used for 
      the healing of bone defects. Its biological applications can be tailored by 
      introducing metallic ions, such as strontium (Sr) and copper (Cu), which can 
      enhance its functionalities, including osteogenetic, angiogenetic and 
      antibacterial functionalities. In this study, Cu and Sr ions were co-doped (ratio 
      1:1) with x = 0.5, 1 and 2 mol% each in glass with an intended nominal 
      composition of 80SiO(2)-(15-2x)CaO-5P(2)O(5)-xCuO-xSrO and synthesized with an 
      evaporation-induced self-assembly (EISA)-based sol-gel technique. XRD confirmed 
      the amorphous nature of the glass, while compositional analysis using ICP-OES 
      confirmed the presence of dopant ions with the required amounts. A TEM study of 
      the MBG powders showed fringes that corresponded to the formation of a highly 
      ordered mesoporous structure. The Cu-Sr-doped MBG showed a positive effect on 
      apatite formation when immersed in SBF, although the release of Cu and Sr ions 
      was relatively slow for 1 mol% of each co-dopant, which signified a stable 
      network structure in the glass. The impact of the Cu and Sr ions on the 
      osteoblast-like cell line MG-63 was assessed. At the particle concentrations of 1 
      wt./vol.% or lower, the cell viability was above 50%. An antibacterial test was 
      conducted against Gram-negative E. coli and Gram-positive S. aureus bacteria. 
      With a sequential increase in the co-doped ion content in the glass, the zone of 
      inhibition for bacteria increased. The results suggest that the doping of MBG 
      with Cu and Sr ions at up to 2 mol% can result in tailored sustained release of 
      ions to enhance the applicability of the studied glass as a functional 
      biomaterial for bone regeneration applications.
FAU - Anand, Akrity
AU  - Anand A
AD  - Centre for Functional and Surface Functionalized Glass, Alexander Dubcek 
      University of Trencin, 911 50 Trencin, Slovakia.
AD  - Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, 
      Germany.
FAU - Sengupta, Susanta
AU  - Sengupta S
AD  - Centre for Functional and Surface Functionalized Glass, Alexander Dubcek 
      University of Trencin, 911 50 Trencin, Slovakia.
AD  - Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, 
      Germany.
FAU - Kankova, Hana
AU  - Kankova H
AUID- ORCID: 0000-0001-5494-9754
AD  - Centre for Functional and Surface Functionalized Glass, Alexander Dubcek 
      University of Trencin, 911 50 Trencin, Slovakia.
FAU - Svancarkova, Anna
AU  - Svancarkova A
AD  - Centre for Functional and Surface Functionalized Glass, Alexander Dubcek 
      University of Trencin, 911 50 Trencin, Slovakia.
FAU - Beltran, Ana M
AU  - Beltran AM
AUID- ORCID: 0000-0003-2599-5908
AD  - Departamento de Ingenieria y Ciencia de los Materiales y del Transporte, Escuela 
      Politecnica Superior, Universidad de Sevilla, 41011 Seville, Spain.
FAU - Galusek, Dusan
AU  - Galusek D
AUID- ORCID: 0000-0001-5995-8780
AD  - Centre for Functional and Surface Functionalized Glass, Alexander Dubcek 
      University of Trencin, 911 50 Trencin, Slovakia.
FAU - Boccaccini, Aldo R
AU  - Boccaccini AR
AUID- ORCID: 0000-0002-7377-2955
AD  - Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, 
      Germany.
FAU - Galuskova, Dagmar
AU  - Galuskova D
AUID- ORCID: 0000-0003-4114-1048
AD  - Centre for Functional and Surface Functionalized Glass, Alexander Dubcek 
      University of Trencin, 911 50 Trencin, Slovakia.
LA  - eng
GR  - 739566 and VEGA 1/0191/20/European Union's Horizon 2020 research and innovation 
      program/
PT  - Journal Article
DEP - 20221116
PL  - Switzerland
TA  - Gels
JT  - Gels (Basel, Switzerland)
JID - 101696925
PMC - PMC9689600
OTO - NOTNLM
OT  - antibacterial activity
OT  - bioactivity
OT  - co-doping
OT  - cytotoxicity
OT  - mesoporous glass
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/25 06:00
MHDA- 2022/11/25 06:01
PMCR- 2022/11/16
CRDT- 2022/11/24 09:56
PHST- 2022/08/27 00:00 [received]
PHST- 2022/11/01 00:00 [revised]
PHST- 2022/11/04 00:00 [accepted]
PHST- 2022/11/24 09:56 [entrez]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/25 06:01 [medline]
PHST- 2022/11/16 00:00 [pmc-release]
AID - gels8110743 [pii]
AID - gels-08-00743 [pii]
AID - 10.3390/gels8110743 [doi]
PST - epublish
SO  - Gels. 2022 Nov 16;8(11):743. doi: 10.3390/gels8110743.