PMID- 36421684
OWN - NLM
STAT- MEDLINE
DCOM- 20221128
LR  - 20221201
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 11
DP  - 2022 Nov 11
TI  - cGMP Signaling in the Neurovascular Unit-Implications for Retinal Ganglion Cell 
      Survival in Glaucoma.
LID - 10.3390/biom12111671 [doi]
LID - 1671
AB  - Glaucoma is a progressive age-related disease of the visual system and the 
      leading cause of irreversible blindness worldwide. Currently, intraocular 
      pressure (IOP) is the only modifiable risk factor for the disease, but even as 
      IOP is lowered, the pathology of the disease often progresses. Hence, effective 
      clinical targets for the treatment of glaucoma remain elusive. Glaucoma shares 
      comorbidities with a multitude of vascular diseases, and evidence in humans and 
      animal models demonstrates an association between vascular dysfunction of the 
      retina and glaucoma pathology. Integral to the survival of retinal ganglion cells 
      (RGCs) is functional neurovascular coupling (NVC), providing RGCs with metabolic 
      support in response to neuronal activity. NVC is mediated by cells of the 
      neurovascular unit (NVU), which include vascular cells, glial cells, and neurons. 
      Nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling is a prime 
      mediator of NVC between endothelial cells and neurons, but emerging evidence 
      suggests that cGMP signaling is also important in the physiology of other cells 
      of the NVU. NO-cGMP signaling has been implicated in glaucomatous 
      neurodegeneration in humans and mice. In this review, we explore the role of cGMP 
      signaling in the different cell types of the NVU and investigate the potential 
      links between cGMP signaling, breakdown of neurovascular function, and glaucoma 
      pathology.
FAU - Haider, Ameer A
AU  - Haider AA
AD  - Vanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, 
      Vanderbilt University Medical Center, Nashville, TN 37212, USA.
FAU - Rex, Tonia S
AU  - Rex TS
AUID- ORCID: 0000-0002-2566-8723
AD  - Vanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, 
      Vanderbilt University Medical Center, Nashville, TN 37212, USA.
FAU - Wareham, Lauren K
AU  - Wareham LK
AUID- ORCID: 0000-0003-4512-6355
AD  - Vanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, 
      Vanderbilt University Medical Center, Nashville, TN 37212, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221111
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Retinal Ganglion Cells/metabolism
MH  - Endothelial Cells/metabolism
MH  - *Glaucoma/metabolism
MH  - Cyclic GMP/metabolism
MH  - Intraocular Pressure
PMC - PMC9687235
OTO - NOTNLM
OT  - endothelial cell
OT  - glaucoma
OT  - glia
OT  - neurodegeneration
OT  - neurovascular coupling
OT  - neurovascular unit
OT  - retina
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/25 06:00
MHDA- 2022/11/29 06:00
PMCR- 2022/11/11
CRDT- 2022/11/24 09:57
PHST- 2022/10/03 00:00 [received]
PHST- 2022/11/07 00:00 [revised]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2022/11/24 09:57 [entrez]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/29 06:00 [medline]
PHST- 2022/11/11 00:00 [pmc-release]
AID - biom12111671 [pii]
AID - biomolecules-12-01671 [pii]
AID - 10.3390/biom12111671 [doi]
PST - epublish
SO  - Biomolecules. 2022 Nov 11;12(11):1671. doi: 10.3390/biom12111671.