PMID- 36422201
OWN - NLM
STAT- MEDLINE
DCOM- 20221128
LR  - 20221128
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 11
DP  - 2022 Nov 17
TI  - Effects of Photobiomodulation in Patients Presenting with Reticular Pseudodrusen: 
      A Retrospective Observational Case Series Study.
LID - 10.3390/medicina58111662 [doi]
LID - 1662
AB  - Background and Objectives: The purpose of this study is to describe the effects 
      of photobiomodulation on drusen regression with patients presenting with 
      reticular pseudodrusen (RPD). Materials and Methods: This study is a 
      retrospective observational case series study including patients presenting with 
      RPD who underwent treatment by photobiomodulation. All patients underwent a 
      complete ophthalmic examination and multimodal imaging prior to treatment, 
      including spectral-domain optical coherence tomography (SD-OCT). Eyes were 
      treated two times per week for six consecutive weeks. Best corrected-visual 
      acuity (BVCA) was measured prior and after treatment for all patients. The number 
      of RPD on the SD-OCT scans centered on the macula and stages of RPD was noted at 
      baseline and 6 months after the first treatment session. Results: Five eyes of 
      five patients were included in the study. Mean BCVA did not change 6 months after 
      treatment compared to baseline. Mean number of RPD per eye was 112.60 +/- 48.33 
      RPD at baseline and 111.6 +/- 49.29 in the same area 6 months after treatment. 
      Changes in RPD distribution according to RPD classification were observed before 
      and after treatment with photobiomodulation. Changes in distribution mostly 
      concerned stages 1 and 3 RPD: Total number of stage 1 RPD was 289 and increased 
      to 324 after treatment. Total number of stage 3 RPD was 97 at baseline and 
      decreased to 67 6 months after treatment. Percentage of stage 1 RPD increased 
      from 46% to 56% after treatment. Percentage of stage 3 RPD decreased from 20% to 
      13% after treatment. Conclusions: Changes in RPD distribution were observed 
      before and after treatment with photobiomodulation. The number of stage 3 
      reticular pseudodrusen decreased while number of stage 1 reticular pseudodrusen 
      increased after treatment.
FAU - Le, Hoang Mai
AU  - Le HM
AD  - Centre Hospitalier Intercommunal de Creteil, 94 000 Creteil, France.
AD  - Faculty of Medicine, University Paris-Est Creteil (UPEC), 94 000 Creteil, France.
FAU - Mehanna, Carl-Joe
AU  - Mehanna CJ
AUID- ORCID: 0000-0002-6758-7972
AD  - Centre Hospitalier Intercommunal de Creteil, 94 000 Creteil, France.
FAU - De Rosa, Irene
AU  - De Rosa I
AUID- ORCID: 0000-0002-9509-2408
AD  - Centre Hospitalier Intercommunal de Creteil, 94 000 Creteil, France.
FAU - Miere, Alexandra
AU  - Miere A
AUID- ORCID: 0000-0003-4123-8210
AD  - Centre Hospitalier Intercommunal de Creteil, 94 000 Creteil, France.
AD  - Faculty of Medicine, University Paris-Est Creteil (UPEC), 94 000 Creteil, France.
FAU - Souied, Eric
AU  - Souied E
AD  - Centre Hospitalier Intercommunal de Creteil, 94 000 Creteil, France.
AD  - Faculty of Medicine, University Paris-Est Creteil (UPEC), 94 000 Creteil, France.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20221117
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Humans
MH  - Fluorescein Angiography/methods
MH  - Retrospective Studies
MH  - *Retinal Drusen/radiotherapy/diagnosis
MH  - Tomography, Optical Coherence/methods
MH  - Retina
PMC - PMC9694204
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - photobiomodulation
OT  - reticular pseudodrusen
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/25 06:00
MHDA- 2022/11/29 06:00
PMCR- 2022/11/17
CRDT- 2022/11/24 10:33
PHST- 2022/08/30 00:00 [received]
PHST- 2022/09/27 00:00 [revised]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/11/24 10:33 [entrez]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/29 06:00 [medline]
PHST- 2022/11/17 00:00 [pmc-release]
AID - medicina58111662 [pii]
AID - medicina-58-01662 [pii]
AID - 10.3390/medicina58111662 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Nov 17;58(11):1662. doi: 10.3390/medicina58111662.