PMID- 36422508
OWN - NLM
STAT- MEDLINE
DCOM- 20221128
LR  - 20230804
IS  - 1303-6165 (Electronic)
IS  - 1300-0144 (Print)
IS  - 1300-0144 (Linking)
VI  - 52
IP  - 5
DP  - 2022 Oct
TI  - Identification of subclinical iron deficiency using new erythrocytes, leukocytes, 
      and reticulocytes parameters during nonsevere acute infection in pediatric 
      outpatients.
PG  - 1674-1681
LID - 10.55730/1300-0144.5509 [doi]
AB  - BACKGROUND: This study aims to investigate the diagnostic utility of new 
      erythrocytes, leukocytes, and reticulocytes parameters for the identification of 
      subclinical iron deficiency (ID) in children under 6 years with nonsevere acute 
      infection in pediatric outpatients. METHODS: The study included 102 children with 
      acute infections and 31 true ID. Traditional and new hematology parameters were 
      measured in a Sysmex-XN(R), along with C-reactive protein level, and iron 
      parameters. Participants' ID were categorized as: the ferritin < 100 ng/mL, 
      transferrin saturation < 20% was defined as "subclinical or functional ID (FID) 
      in Group 1"; ferritin < 30 ng/mL, transferrin saturation < 20%, as "absolute-ID 
      (AID)" in Group 2; ferritin < 12 ng/mL without anemia and infection, as "true ID" 
      in Group 3. RESULTS: The frequencies of FID and AID among the 102 children with 
      acute infection were 24% and 76%, respectively. Compared with the Group 2 
      patients, Group 1 had a significantly higher mean percentage of hypochromic 
      erythrocytes (Hypo-He), and significantly lower levels of hemoglobin (Hb) and Hb 
      content of reticulocytes (RET-He) (p < 0.05 for all). Compared with Group 2 and 
      Group 3 patients, Group 1 had a significantly higher mean percentage of immature 
      reticulocyte fraction (IRF) and immature granulocyte (IG) values (p < 0.05 for 
      all). The RET-He, IRF%, Hypo-He%, and IG% cut-off values for predicting FID 
      during infection were 27.0 pg, 10.6%, 2.5%, and 0.35% respectively. DISCUSSION: 
      The RET-He, Hypo-He, IRF, and IG may be useful parameters for identifying 
      subclinical ID in small children with nonsevere acute infection in pediatric 
      outpatients.
FAU - Karakas, Nazmi Mutlu
AU  - Karakas NM
AD  - Department of General Pediatric, Faculty of Medicine, Gazi University, Ankara, 
      Turkey.
FAU - Kirkiz, Serap
AU  - Kirkiz S
AD  - Department of Pediatric Hematology, Faculty of Medicine, Gazi University, Ankara, 
      Turkey.
FAU - Kaya, Zuhre
AU  - Kaya Z
AD  - Department of Pediatric Hematology, Faculty of Medicine, Gazi University, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20221019
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 0 (Hemoglobins)
RN  - 9007-73-2 (Ferritins)
RN  - 0 (Transferrins)
SB  - IM
MH  - Humans
MH  - Child
MH  - Child, Preschool
MH  - Reticulocytes/chemistry/metabolism
MH  - *Iron Deficiencies
MH  - Outpatients
MH  - *Anemia, Iron-Deficiency/diagnosis/metabolism
MH  - Erythrocytes/metabolism
MH  - Hemoglobins/analysis
MH  - Ferritins/metabolism
MH  - Leukocytes/metabolism
MH  - Transferrins/metabolism
PMC - PMC10395708
OTO - NOTNLM
OT  - Medical intensive care unit
OT  - child
OT  - infection
EDAT- 2022/11/25 06:00
MHDA- 2022/11/29 06:00
PMCR- 2022/05/29
CRDT- 2022/11/24 10:53
PHST- 2021/12/13 00:00 [received]
PHST- 2022/05/29 00:00 [accepted]
PHST- 2022/11/24 10:53 [entrez]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/29 06:00 [medline]
PHST- 2022/05/29 00:00 [pmc-release]
AID - turkjmedsci-52-5-1674 [pii]
AID - 10.55730/1300-0144.5509 [doi]
PST - ppublish
SO  - Turk J Med Sci. 2022 Oct;52(5):1674-1681. doi: 10.55730/1300-0144.5509. Epub 2022 
      Oct 19.