PMID- 36424025 OWN - NLM STAT- MEDLINE DCOM- 20221128 LR - 20230201 IS - 1558-3163 (Electronic) IS - 0889-857X (Linking) VI - 49 IP - 1 DP - 2023 Feb TI - Atherosclerotic Cardiovascular Risk Stratification in the Rheumatic Diseases:: An Integrative, Multiparametric Approach. PG - 19-43 LID - S0889-857X(22)00067-9 [pii] LID - 10.1016/j.rdc.2022.07.004 [doi] AB - Cardiovascular disease (CVD) risk is increased in most inflammatory rheumatic diseases (IRDs), reiterating the role of inflammation in the initiation and progression of atherosclerosis. An inverse association of CVD risk with body weight and lipid levels has been described in IRDs. Coronary artery calcium scores, plaque burden and characteristics, and carotid plaques on ultrasound optimize CVD risk estimate in IRDs. Biomarkers of cardiac injury, autoantibodies, lipid biomarkers, and cytokines also improve risk assessment in IRDs. Machine learning and deep learning algorithms for phenotype and image analysis hold promise to improve CVD risk stratification in IRDs. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Misra, Durga Prasanna AU - Misra DP AD - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Rae Bareli Road, Lucknow 226014, India. FAU - Hauge, Ellen M AU - Hauge EM AD - Division of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99 DK-8200, Aarhus, Denmark. FAU - Crowson, Cynthia S AU - Crowson CS AD - Department of Quantitative Health Sciences and Division of Rheumatology, Mayo Clinic, 200 first St SW, Rochester, MN 55905, USA. FAU - Kitas, George D AU - Kitas GD AD - Dudley Group NHS Foundation Trust, United Kingdom. FAU - Ormseth, Sarah R AU - Ormseth SR AD - The Lundquist Institute and Harbor-UCLA Medical Center, 1124 West Carson Street, Building E4-R17, Torrance, CA 90502, USA. FAU - Karpouzas, George A AU - Karpouzas GA AD - The Lundquist Institute and Harbor-UCLA Medical Center, 1124 West Carson Street, Building E4-R17, Torrance, CA 90502, USA. Electronic address: gkarpouzas@lundquist.org. LA - eng GR - R01 HL126827/HL/NHLBI NIH HHS/United States GR - R01 HL146754/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review PL - United States TA - Rheum Dis Clin North Am JT - Rheumatic diseases clinics of North America JID - 8708093 RN - 0 (Biomarkers) RN - 0 (Lipids) SB - IM MH - Humans MH - *Cardiovascular Diseases/epidemiology/etiology MH - Risk Factors MH - *Atherosclerosis/etiology MH - *Plaque, Atherosclerotic/diagnostic imaging MH - *Rheumatic Diseases/complications MH - Biomarkers MH - Lipids OTO - NOTNLM OT - Ankylosing spondylitis OT - Cardiovascular risk factors OT - Cardiovascular risk score OT - Psoriatic arthritis OT - Rheumatoid arthritis OT - Systemic lupus erythematosus EDAT- 2022/11/25 06:00 MHDA- 2022/11/29 06:00 CRDT- 2022/11/24 21:04 PHST- 2022/11/24 21:04 [entrez] PHST- 2022/11/25 06:00 [pubmed] PHST- 2022/11/29 06:00 [medline] AID - S0889-857X(22)00067-9 [pii] AID - 10.1016/j.rdc.2022.07.004 [doi] PST - ppublish SO - Rheum Dis Clin North Am. 2023 Feb;49(1):19-43. doi: 10.1016/j.rdc.2022.07.004.