PMID- 36424029 OWN - NLM STAT- MEDLINE DCOM- 20221128 LR - 20230201 IS - 1558-3163 (Electronic) IS - 0889-857X (Linking) VI - 49 IP - 1 DP - 2023 Feb TI - Venous Thromboembolism in the Inflammatory Rheumatic Diseases. PG - 97-127 LID - S0889-857X(22)00070-9 [pii] LID - 10.1016/j.rdc.2022.08.001 [doi] AB - Venous thromboembolism (VTE), which includes deep venous thrombosis and pulmonary embolism, is a cardiovascular event whose risk is increased in most inflammatory rheumatic diseases (IRDs). Mechanisms that increase VTE risk include antiphospholipid antibodies (APLs), particularly anticardiolipin antibodies, anti-beta2glycoprotein I antibodies and lupus anticoagulant present together, and inflammation-mediated endothelial injury. Patients with IRDs should receive long-term anticoagulation drugs when the risk of VTE recurrence is high. In the light of recent warnings from regulatory agencies regarding heightened VTE risk with Janus kinase inhibitors, these drugs should be initiated only after a careful assessment of VTE risk in those with IRDs. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Misra, Durga Prasanna AU - Misra DP AD - Department of Clinical Immunology and Rheumatology, C block, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Rae Bareli Road, Lucknow 226014, India. Electronic address: durgapmisra@gmail.com. FAU - Ahmed, Sakir AU - Ahmed S AD - Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar 751024, India. Electronic address: https://twitter.com/sakir_rheum. FAU - Goyal, Mohit AU - Goyal M AD - Department of Rheumatology and Clinical Immunology, CARE Pain and Arthritis Centre, Udaipur 313002, Rajasthan, India. Electronic address: https://twitter.com/drmohitgoyal. FAU - Sharma, Aman AU - Sharma A AD - Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India. Electronic address: https://twitter.com/Amansharmapgi. FAU - Agarwal, Vikas AU - Agarwal V AD - Department of Clinical Immunology and Rheumatology, C block, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Rae Bareli Road, Lucknow 226014, India. Electronic address: https://twitter.com/vikasagrIMMUNO. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Rheum Dis Clin North Am JT - Rheumatic diseases clinics of North America JID - 8708093 RN - 0 (Antibodies, Antiphospholipid) SB - IM MH - Humans MH - *Venous Thromboembolism/etiology MH - Antibodies, Antiphospholipid MH - *Antiphospholipid Syndrome/complications/diagnosis MH - Inflammation MH - *Rheumatic Diseases/complications OTO - NOTNLM OT - Antiphospholipid antibody syndrome OT - Cardiovascular diseases OT - Deep venous thrombosis OT - Pulmonary embolism OT - Rheumatoid arthritis OT - Systemic lupus erythematosus OT - Vasculitis OT - Venous thromboembolism COIS- Disclosure The authors have nothing to disclose. EDAT- 2022/11/25 06:00 MHDA- 2022/11/29 06:00 CRDT- 2022/11/24 21:04 PHST- 2022/11/24 21:04 [entrez] PHST- 2022/11/25 06:00 [pubmed] PHST- 2022/11/29 06:00 [medline] AID - S0889-857X(22)00070-9 [pii] AID - 10.1016/j.rdc.2022.08.001 [doi] PST - ppublish SO - Rheum Dis Clin North Am. 2023 Feb;49(1):97-127. doi: 10.1016/j.rdc.2022.08.001.