PMID- 36424548
OWN - NLM
STAT- MEDLINE
DCOM- 20221128
LR  - 20221213
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Nov 24
TI  - Association between serum homocysteine and sarcopenia among hospitalized older 
      Chinese adults: a cross-sectional study.
PG  - 896
LID - 10.1186/s12877-022-03632-0 [doi]
LID - 896
AB  - OBJECTIVE: Hyperhomocysteinemia (HHcy) is considered to increase the risk of 
      sarcopenia (S) and remains controversial. In this study, we aimed to investigate 
      the prevalence of S among older Chinese adults and explore whether homocysteine 
      (Hcy) was independently associated with S. METHODS: This cross-sectional study 
      was performed among older adults hospitalized in the Geriatric Hospital of 
      Nanjing Medical University between June 2017 and December 2021. We measured all 
      participants' serum Hcy levels, hand grip strength, gait speed and appendicular 
      skeletal muscle index(ASMI) using bioelectrical impedance analysis (BIA). S was 
      defined based on the criteria of the Asian Working Group for Sarcopenia 2 
      (AWGS2), which included muscle mass (ASMI< 7.0 kg/m(2) for men and 
      ASMI< 5.7 kg/m(2) for women by BIA) and low muscle strength (handgrip strength 
      < 28 kg for men and < 18 kg for women), and/or gait speed < 1.0 m/s. HHcy defined 
      as Hcy >/=10 mumol/L. The strength of the association between Hcy and the risk of S 
      was analyzed by multivariate logistic regression using three models that adjusted 
      for possible confounding variables to calculate the odds ratios (ORs) and 95% 
      confidence intervals (CIs). RESULTS: Among the 441 subjects, 161 (36.5%) were 
      diagnosed with S, and 343 (77.8%) were diagnosed with HHcy. A significant 
      association was detected between S and serum Hcy per 1-mumol/L increase after 
      adjustment for age, gender, education, smoking, body mass index (BMI), Mini 
      Nutritional Assessment Short Form (MNA-SF), alanine aminotransferase (ALT), 
      C-reactive protein (CRP), hemoglobin (Hb), albumin (ALB), diabetes, kidney 
      disease, and statin use (OR = 1.07, 95% CI = 1.03-1.12, P = 0.002). The OR for S 
      in the HHcy group (>/=10 mumol/L) was nearly 5-fold that in the normal Hcy group (OR 
      4.96, 95% CI 2.67-9.24, P < 0.001). In a gender-based subgroup analysis that 
      adjusted for age, education, smoking, BMI, MNA-SF, ALT, CRP, Hb, and ALB, female 
      subjects with HHcy had an increased risk of S (OR 10.35, 95% CI 2.84-37.68, 
      P < 0.001). CONCLUSIONS: Our results demonstrated that elevated Hcy levels have 
      an independent association with S in older adults. This suggests that the 
      downward adjustment of HHcy (cutoff value < 10 mumol/l) might decrease the risk of 
      S.
CI  - (c) 2022. The Author(s).
FAU - Lu, Bing
AU  - Lu B
AD  - Department of Geriatrics, Geriatric Hospital of Nanjing Medical University, 65 
      Jiangsu Road, Nanjing, 210024, China.
FAU - Shen, Lingyu
AU  - Shen L
AD  - Chronic Disease and Health Management Research Center, Geriatric Hospital of 
      Nanjing Medical University, 65 Jiangsu Road, Nanjing, 210024, China.
FAU - Zhu, Haiqiong
AU  - Zhu H
AD  - Department of Geriatrics, Geriatric Hospital of Nanjing Medical University, 65 
      Jiangsu Road, Nanjing, 210024, China.
FAU - Xi, Ling
AU  - Xi L
AD  - Department of Geriatrics, Geriatric Hospital of Nanjing Medical University, 65 
      Jiangsu Road, Nanjing, 210024, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Chronic Disease and Health Management Research Center, Geriatric Hospital of 
      Nanjing Medical University, 65 Jiangsu Road, Nanjing, 210024, China. 
      wwtxdy@163.com.
FAU - Ouyang, Xiaojun
AU  - Ouyang X
AD  - Department of Geriatrics, Geriatric Hospital of Nanjing Medical University, 65 
      Jiangsu Road, Nanjing, 210024, China. xiaojun_ouyang@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221124
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Sarcopenia/diagnosis/epidemiology
MH  - Cross-Sectional Studies
MH  - Hand Strength/physiology
MH  - Homocysteine
MH  - China/epidemiology
PMC - PMC9685861
OTO - NOTNLM
OT  - Homocysteine
OT  - Hyperhomocysteinemia
OT  - Older adults
OT  - Sarcopenia
COIS- The authors declare that they have no competing interests.
EDAT- 2022/11/25 06:00
MHDA- 2022/11/29 06:00
PMCR- 2022/11/24
CRDT- 2022/11/24 23:35
PHST- 2022/07/29 00:00 [received]
PHST- 2022/11/17 00:00 [accepted]
PHST- 2022/11/24 23:35 [entrez]
PHST- 2022/11/25 06:00 [pubmed]
PHST- 2022/11/29 06:00 [medline]
PHST- 2022/11/24 00:00 [pmc-release]
AID - 10.1186/s12877-022-03632-0 [pii]
AID - 3632 [pii]
AID - 10.1186/s12877-022-03632-0 [doi]
PST - epublish
SO  - BMC Geriatr. 2022 Nov 24;22(1):896. doi: 10.1186/s12877-022-03632-0.