PMID- 36425761
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221126
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 25
IP  - 12
DP  - 2022 Dec 22
TI  - Usnic Acid extends healthspan and improves the neurodegeneration diseases via 
      mTOR/PHA-4 signaling pathway in Caenorhabditis elegans.
PG  - 105539
LID - 10.1016/j.isci.2022.105539 [doi]
LID - 105539
AB  - The Mammalian/mechanistic target of rapamycin (mTOR) played a central role in 
      cellular survival and aging. Inhibition of mTOR had been proposed as a reasonable 
      strategy to promote lifespan and delay age-related diseases in evolutionarily 
      diverse organisms. The study showed that lifespan extension and age-related 
      diseases improvement could be achieved by targeting evolutionarily conserved mTOR 
      pathways and mechanisms using pharmacological interventions. Using this approach 
      in Caenorhabditis elegans, We found that 2 muM Usnic Acid significantly extended 
      the healthy lifespan in wild-type animals. Furthermore, via genetic screen, we 
      showed that Usnic Acid acted on mTOR, which was followed by the activation of 
      PHA-4/Foxa to extend the healthy lifespan. Intriguingly, Usnic Acid also delayed 
      neurodegeneration diseases such as Alzheimer's and polyglutamine disease through 
      mTOR-dependent manner. Our work suggested that Usnic Acid might be a viable 
      candidate for the prevention and treatment of aging and age-related diseases.
CI  - (c) 2022 The Author(s).
FAU - Xiao, Yi
AU  - Xiao Y
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Zhang, Huiling
AU  - Zhang H
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Sheng, Yi
AU  - Sheng Y
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Liu, Fang
AU  - Liu F
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - College of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Gao, Jiajun
AU  - Gao J
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
FAU - Liu, Guosheng
AU  - Liu G
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - College of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Li, Sanhua
AU  - Li S
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Jiang, Nian
AU  - Jiang N
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Yu, Changyan
AU  - Yu C
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
FAU - Liu, Yun
AU  - Liu Y
AD  - Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with 
      Distinctive Medicines, Zunyi Medical University, Zunyi, Guizhou 563000, China.
AD  - Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
AD  - College of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20221109
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC9679492
OTO - NOTNLM
OT  - Biochemistry
OT  - biological sciences
OT  - molecular biology
OT  - neuroscience
COIS- The authors declare no competing interests.
EDAT- 2022/11/26 06:00
MHDA- 2022/11/26 06:01
PMCR- 2022/11/09
CRDT- 2022/11/25 02:52
PHST- 2022/06/08 00:00 [received]
PHST- 2022/10/01 00:00 [revised]
PHST- 2022/11/04 00:00 [accepted]
PHST- 2022/11/25 02:52 [entrez]
PHST- 2022/11/26 06:00 [pubmed]
PHST- 2022/11/26 06:01 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - S2589-0042(22)01811-9 [pii]
AID - 105539 [pii]
AID - 10.1016/j.isci.2022.105539 [doi]
PST - epublish
SO  - iScience. 2022 Nov 9;25(12):105539. doi: 10.1016/j.isci.2022.105539. eCollection 
      2022 Dec 22.