PMID- 36426397 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221217 IS - 2092-7355 (Print) IS - 2092-7363 (Electronic) IS - 2092-7355 (Linking) VI - 14 IP - 6 DP - 2022 Nov TI - Phenotype of Atopic Dermatitis With Food Allergy Predicts Development of Childhood Asthma via Gut Wnt Signaling. PG - 674-686 LID - 10.4168/aair.2022.14.6.674 [doi] AB - PURPOSE: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a wide spectrum of clinical phenotype. However, specific description of phenotypes of AD depending on the comorbidities in early childhood is lacking. This study aimed to investigate whether the AD phenotype in early childhood is related to childhood asthma and to elucidate the mechanisms involved. METHODS: Data on the first 3 years of life were collected prospectively from 1,699 children in the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). We applied an unsupervised latent class analysis to the following five factors: food sensitization, inhalant sensitization, food allergy (FA), AD, and recurrent wheezing. The risks of developing FA, AD, allergic rhinitis (AR), and asthma in children aged 5-7 years were evaluated. Colonocyte transcriptome and ingenuity pathway analysis were performed. RESULTS: Four phenotypes were identified; no allergic diseases (78.4%), AD without sensitization (16.4%), FA with AD (2.9%), and AD with sensitization (7.8%). The FA with AD had the highest risk for FA, AR, and asthma and the highest cord blood immunoglobulin E (IgE) levels. In AD without sensitization and with sensitization, scoring of AD (SCORAD) in early childhood was higher than in FA with AD. Canonical pathway analysis with the colonocyte transcriptome revealed that the key pathway in FA with AD was 'Wnt/beta-catenin Signaling.' The relative abundance of Wnt6 mRNA was positively correlated with food-specific IgE levels at 1 and 3 years. CONCLUSIONS: When FA is present in various phenotypes of AD at early life, regardless of severity of eczema, it may be associated with gut Wnt signaling and later development of asthma. CI - Copyright (c) 2022 The Korean Academy of Asthma, Allergy and Clinical Immunology * The Korean Academy of Pediatric Allergy and Respiratory Disease. FAU - Lee, So-Yeon AU - Lee SY AD - Department of Pediatrics, Childhood Asthma and Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. FAU - Kim, Sangrok AU - Kim S AD - Department of Information Management, Medical Record Information Team, Hanyang University Medical Center, Seoul, Korea. FAU - Kang, Mi Jin AU - Kang MJ AD - Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. FAU - Song, Kun-Baek AU - Song KB AD - Department of Pediatrics, Soonchunhyang Cheonan Hospital, University of Soonchunhyang College of Medicine, Cheonan, Korea. FAU - Choi, Eom Ji AU - Choi EJ AD - Department of Pediatrics, Childhood Asthma and Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. FAU - Jung, Sungsu AU - Jung S AD - Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea. FAU - Yoon, Ji-Sun AU - Yoon JS AD - Department of Pediatrics, Chung-Ang University Hospital, Gwangmyeong, Korea. FAU - Suh, Dong In AU - Suh DI AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. FAU - Shin, Youn Ho AU - Shin YH AD - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. FAU - Kim, Kyung Won AU - Kim KW AD - Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. FAU - Ahn, Kangmo AU - Ahn K AD - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. FAU - Hong, Soo-Jong AU - Hong SJ AD - Department of Pediatrics, Childhood Asthma and Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr. LA - eng GR - NRF-2020R1A2C2012822/National Research Foundation of Korea/Korea GR - 2008-E33030-00/Korea Disease Control and Prevention Agency/Korea GR - 2009-E33033-00/Korea Disease Control and Prevention Agency/Korea GR - 2011-E33021-00/Korea Disease Control and Prevention Agency/Korea GR - 2012-E33012-00/Korea Disease Control and Prevention Agency/Korea GR - 2013-E51003-00/Korea Disease Control and Prevention Agency/Korea GR - 2014-E51004-00/Korea Disease Control and Prevention Agency/Korea GR - 2014-E5 1004-01/Korea Disease Control and Prevention Agency/Korea GR - 2014-E5 1004-02/Korea Disease Control and Prevention Agency/Korea GR - 2017-E6 7002-00/Korea Disease Control and Prevention Agency/Korea GR - 2017-E6 7002-01/Korea Disease Control and Prevention Agency/Korea GR - 2017-E6 7002-02/Korea Disease Control and Prevention Agency/Korea PT - Journal Article PL - Korea (South) TA - Allergy Asthma Immunol Res JT - Allergy, asthma & immunology research JID - 101518382 PMC - PMC9709687 OTO - NOTNLM OT - Asthma OT - Wnt signaling pathway OT - atopic OT - dermatitis OT - food hypersensitivity OT - latent class analysis OT - phenotype OT - transcriptome COIS- There are no financial or other issues that might lead to conflict of interest. EDAT- 2022/11/26 06:00 MHDA- 2022/11/26 06:01 PMCR- 2022/11/01 CRDT- 2022/11/25 03:05 PHST- 2022/07/12 00:00 [received] PHST- 2022/07/12 00:00 [revised] PHST- 2022/08/23 00:00 [accepted] PHST- 2022/11/25 03:05 [entrez] PHST- 2022/11/26 06:00 [pubmed] PHST- 2022/11/26 06:01 [medline] PHST- 2022/11/01 00:00 [pmc-release] AID - 14.674 [pii] AID - 10.4168/aair.2022.14.6.674 [doi] PST - ppublish SO - Allergy Asthma Immunol Res. 2022 Nov;14(6):674-686. doi: 10.4168/aair.2022.14.6.674.