PMID- 36426844
OWN - NLM
STAT- MEDLINE
DCOM- 20230201
LR  - 20230201
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 34
IP  - 12
DP  - 2022 Dec
TI  - Synaptic control of rat magnocellular neurosecretory cells by warm-sensing 
      neurons in the organum vasculosum lamina terminalis.
PG  - e13214
LID - 10.1111/jne.13214 [doi]
AB  - Increases in core body temperature cause secretion of vasopressin (vasopressin, 
      antidiuretic hormone) to promote water reabsorption and blunt water losses 
      incurred through homeostatic evaporative cooling. Subtypes of transient receptor 
      potential vanilloid (Trpv) channels have been shown to contribute to the 
      intrinsic regulation of vasopressin-releasing magnocellular neurosecretory cells 
      (MNCs) in the supraoptic nucleus (SON) and paraventricular nucleus (PVN). 
      However, MNCs in vivo can also be excited by local heating of the adjacent 
      preoptic area, indicating they receive thermosensory information from other 
      areas. Here, we investigated whether neurons in the organum vasculosum lamina 
      terminalis (OVLT) contribute to this process using in vitro electrophysiological 
      approaches in male rats. We found that the majority of OVLT neurons are 
      thermosensitive in the physiological range (36-39 degrees C) and that this property is 
      retained under conditions blocking synaptic transmission. A subset of these 
      neurons could be antidromically activated by electrical stimulation in the SON. 
      Whole cell recordings from SON MNCs revealed that heating significantly increases 
      the rate of spontaneous excitatory postsynaptic currents (sEPCSs), and that this 
      response is abolished by lesions targeting the OVLT, but not by bilateral lesions 
      placed in the adjacent preoptic area. Finally, local heating of the OVLT caused a 
      significant excitation of MNCs in the absence of temperature changes in the SON, 
      and this effect was blocked by inhibitors of ionotropic glutamate receptors. 
      These findings indicate that the OVLT serves as an important thermosensory 
      nucleus and contributes to the activation of MNCs during physiological heating.
CI  - (c) 2022 British Society for Neuroendocrinology.
FAU - Sudbury, Jessica R
AU  - Sudbury JR
AD  - Brain Repair and Integrative Neuroscience Program, Research Institute of the 
      McGill University Health Centre, Montreal, Quebec, Canada.
FAU - Zaelzer, Cristian
AU  - Zaelzer C
AD  - Brain Repair and Integrative Neuroscience Program, Research Institute of the 
      McGill University Health Centre, Montreal, Quebec, Canada.
FAU - Trudel, Eric
AU  - Trudel E
AD  - Brain Repair and Integrative Neuroscience Program, Research Institute of the 
      McGill University Health Centre, Montreal, Quebec, Canada.
FAU - Bumagin, Anna
AU  - Bumagin A
AD  - Brain Repair and Integrative Neuroscience Program, Research Institute of the 
      McGill University Health Centre, Montreal, Quebec, Canada.
FAU - Bourque, Charles W
AU  - Bourque CW
AUID- ORCID: 0000-0002-1594-742X
AD  - Brain Repair and Integrative Neuroscience Program, Research Institute of the 
      McGill University Health Centre, Montreal, Quebec, Canada.
LA  - eng
GR  - PJT 178036/CIHR/Canada
GR  - FDN 143337/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221125
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 11000-17-2 (Vasopressins)
SB  - IM
MH  - Animals
MH  - Male
MH  - Rats
MH  - Hypothalamus
MH  - Neurons/physiology
MH  - *Organum Vasculosum/physiology
MH  - Supraoptic Nucleus
MH  - Vasopressins/pharmacology
MH  - *Neurosecretory Systems/physiology
OTO - NOTNLM
OT  - OVLT
OT  - supraoptic nucleus
OT  - thermosensitivity
OT  - vasopressin
EDAT- 2022/11/26 06:00
MHDA- 2022/12/27 06:00
CRDT- 2022/11/25 07:42
PHST- 2022/10/07 00:00 [revised]
PHST- 2022/04/22 00:00 [received]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/11/26 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/11/25 07:42 [entrez]
AID - 10.1111/jne.13214 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2022 Dec;34(12):e13214. doi: 10.1111/jne.13214. Epub 2022 Nov 
      25.