PMID- 36427009
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20230421
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 209
IP  - 12
DP  - 2022 Dec 15
TI  - The Human Dendritic Cell Atlas: An Integrated Transcriptional Tool to Study Human 
      Dendritic Cell Biology.
PG  - 2352-2361
LID - 10.4049/jimmunol.2200366 [doi]
AB  - Dendritic cells (DCs) are functionally diverse and are present in most adult 
      tissues, but deep understanding of human DC biology is hampered by relatively 
      small numbers of these in circulation and their short lifespan in human tissues. 
      We built a transcriptional atlas of human DCs by combining samples from 14 
      expression profiling studies derived from 10 laboratories. We identified 
      significant gene expression variation of DC subset-defining markers across tissue 
      type and upon viral or bacterial stimulation. We further highlight critical gaps 
      between in vitro-derived DC subsets and their in vivo counterparts and provide 
      evidence that monocytes or cord blood progenitor in vitro-differentiated DCs fail 
      to capture the repertoire of primary DC subsets or behaviors. In constructing a 
      reference DC atlas, we provide an important resource for the community wishing to 
      identify and annotate tissue-specific DC subsets from single-cell datasets, or 
      benchmark new in vitro models of DC biology.
CI  - Copyright (c) 2022 by The American Association of Immunologists, Inc.
FAU - Elahi, Zahra
AU  - Elahi Z
AUID- ORCID: 0000-0002-0697-3917
AD  - Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health 
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Angel, Paul W
AU  - Angel PW
AUID- ORCID: 0000-0002-0478-0847
AD  - Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health 
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Butcher, Suzanne K
AU  - Butcher SK
AUID- ORCID: 0000-0003-0026-4922
AD  - Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health 
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Rajab, Nadia
AU  - Rajab N
AUID- ORCID: 0000-0001-7253-4819
AD  - Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health 
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Choi, Jarny
AU  - Choi J
AUID- ORCID: 0000-0002-7788-8867
AD  - Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health 
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Deng, Yidi
AU  - Deng Y
AD  - Melbourne Integrative Genomics, School of Mathematics and Statistics, The 
      University of Melbourne, Parkville, Victoria, Australia.
FAU - Mintern, Justine D
AU  - Mintern JD
AUID- ORCID: 0000-0002-3797-8577
AD  - Department of Biochemistry and Pharmacology, Bio21 Molecular Science and 
      Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 
      Australia; and.
FAU - Radford, Kristen
AU  - Radford K
AUID- ORCID: 0000-0001-6512-6323
AD  - Mater Research Institute, The University of Queensland, Brisbane, Queensland, 
      Australia.
FAU - Wells, Christine A
AU  - Wells CA
AUID- ORCID: 0000-0003-3133-3628
AD  - Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health 
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221102
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Humans
MH  - *Dendritic Cells/metabolism
MH  - Cell Differentiation
MH  - *Monocytes
MH  - Biology
PMC - PMC9719841
COIS- The authors have no financial conflicts of interest.
EDAT- 2022/11/26 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/12/15
CRDT- 2022/11/25 09:53
PHST- 2022/06/07 00:00 [received]
PHST- 2022/10/09 00:00 [accepted]
PHST- 2022/11/25 09:53 [entrez]
PHST- 2022/11/26 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/12/15 00:00 [pmc-release]
AID - 237295 [pii]
AID - ji_2200366 [pii]
AID - 10.4049/jimmunol.2200366 [doi]
PST - ppublish
SO  - J Immunol. 2022 Dec 15;209(12):2352-2361. doi: 10.4049/jimmunol.2200366. Epub 
      2022 Nov 2.