PMID- 36428496
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 11
DP  - 2022 Nov 14
TI  - Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction.
LID - 10.3390/biomedicines10112923 [doi]
LID - 2923
AB  - This study aimed to investigate the relationship between the lymph node ratio 
      (LNR) and survival results of patients with head and neck squamous cell carcinoma 
      (HNSCC) reconstructed by a submental artery flap (SMAF) to limit tumor size. This 
      study retrospectively recruited 49 patients with HNSCC who underwent both primary 
      resection and neck dissection with SMAF reconstruction. The LNR was the ratio of 
      the number of metastatic lymph nodes to the sum number of examined lymph nodes. A 
      LNR of 0.04 was the best cut-off value for HNSCC-specific death on receiver 
      operating curve analysis. Patients with LNRs > 0.04 were univariately related to 
      cancer-specific, disease-free, distant metastasis-free, and locoregional 
      recurrence-free survival than those with LNRs </= 0.04 by log-rank test. In a Cox's 
      proportional hazards model with hazard ratio (HR) and 95% confidence interval 
      (CI) adjusting for pathological stage, extranodal extension and or surgical 
      margins, the LNR (>0.04/</=0.04) predicted multivariate shorter cancer-specific (HR 
      = 9.24, 95% CI = 1.49-176), disease-free (HR = 3.44, 95% CI = 1.23-10.3), and 
      distant metastasis-free (HR = 9.76, 95% CI = 1.57-187) survival. In conclusion, 
      LNR for patients of HNSCC with SMAF reconstruction for limited tumor size was a 
      prognostic factor for survival outcomes.
FAU - Suzuki, Hidenori
AU  - Suzuki H
AD  - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 
      464-8681, Aichi, Japan.
FAU - Beppu, Shintaro
AU  - Beppu S
AD  - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 
      464-8681, Aichi, Japan.
FAU - Nishikawa, Daisuke
AU  - Nishikawa D
AD  - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 
      464-8681, Aichi, Japan.
FAU - Terada, Hoshino
AU  - Terada H
AD  - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 
      464-8681, Aichi, Japan.
FAU - Sawabe, Michi
AU  - Sawabe M
AD  - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 
      464-8681, Aichi, Japan.
FAU - Hanai, Nobuhiro
AU  - Hanai N
AD  - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 
      464-8681, Aichi, Japan.
LA  - eng
GR  - 21K09575/the Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20221114
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9687667
OTO - NOTNLM
OT  - head and neck
OT  - lymph node ratio
OT  - squamous cell carcinoma
OT  - submental artery flap
OT  - survival
COIS- The authors declared no conflict of interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/27 06:01
PMCR- 2022/11/14
CRDT- 2022/11/26 01:04
PHST- 2022/10/17 00:00 [received]
PHST- 2022/11/02 00:00 [revised]
PHST- 2022/11/10 00:00 [accepted]
PHST- 2022/11/26 01:04 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/27 06:01 [medline]
PHST- 2022/11/14 00:00 [pmc-release]
AID - biomedicines10112923 [pii]
AID - biomedicines-10-02923 [pii]
AID - 10.3390/biomedicines10112923 [doi]
PST - epublish
SO  - Biomedicines. 2022 Nov 14;10(11):2923. doi: 10.3390/biomedicines10112923.