PMID- 36428828
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221213
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 11
DP  - 2022 Nov 12
TI  - Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome-Related Skin 
      Tumors.
LID - 10.3390/diagnostics12112768 [doi]
LID - 2768
AB  - Non-endocrine findings in patients with MEN1 (multiple endocrine neoplasia) 
      syndrome also include skin lesions, especially tumor-type lesions. This is a 
      narrative review of the English-language medical literature including original 
      studies concerning MEN1 and dermatological issues (apart from dermatologic 
      features of each endocrine tumor/neuroendocrine neoplasia), identified through a 
      PubMed-based search (based on clinical relevance, with no timeline restriction or 
      concern regarding the level of statistical significance). We identified 27 
      original studies involving clinical presentation of patients with MEN1 and 
      cutaneous tumors; eight other original studies that also included the genetic 
      background; and four additional original studies were included. The largest 
      cohorts were from studies in Italy (N = 145 individuals), Spain (N = 90), the 
      United States (N = 48 and N = 32), and Japan (N = 28). The age of patients varied 
      from 18 to 76 years, with the majority of individuals in their forties. The most 
      common cutaneous tumors are angiofibromas (AF), collagenomas (CG), and lipomas 
      (L). Other lesions are atypical nevi, basocellular carcinoma, squamous cell 
      carcinoma, acrochordons, papillomatosis confluens et reticularis, gingival 
      papules, and cutaneous T-cell lymphoma of the eyelid. Non-tumor aspects are 
      confetti-like hypopigmentation, cafe-au-lait macules, and gingival papules. MEN1 
      gene, respective menin involvement has also been found in melanomas, but the 
      association with MEN1 remains debatable. Typically, cutaneous tumors (AF, CG, and 
      L) are benign and are surgically treated only for cosmetic reasons. Some of them 
      are reported as first presentation. Even though skin lesions are not 
      pathognomonic, recognizing them plays an important role in early identification 
      of MEN1 patients. Whether a subgroup of MEN1 subjects is prone to developing 
      these types of cutaneous lesions and how they influence MEN1 evolution is still 
      an open issue.
FAU - Baicoianu-Nitescu, Livia-Cristiana
AU  - Baicoianu-Nitescu LC
AD  - Department of Dermatology, Elias University Emergency Hospital, 011461 Bucharest, 
      Romania.
FAU - Gheorghe, Ana-Maria
AU  - Gheorghe AM
AD  - Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, 
      011863 Bucharest, Romania.
FAU - Carsote, Mara
AU  - Carsote M
AUID- ORCID: 0000-0001-8585-3835
AD  - Department of Endocrinology, C. Davila University of Medicine and Pharmacy & C.I. 
      Parhon National Institute of Endocrinology, 011683 Bucharest, Romania.
FAU - Dumitrascu, Mihai Cristian
AU  - Dumitrascu MC
AD  - Department of Obstetrics and Gynaecology, C. Davila University of Medicine and 
      Pharmacy & University Emergency Hospital, 050474 Bucharest, Romania.
FAU - Sandru, Florica
AU  - Sandru F
AD  - Department of Dermatology, Elias University Emergency Hospital, 011461 Bucharest, 
      Romania.
AD  - Department of Dermatology, C. Davila University of Medicine and Pharmacy & Elias 
      University Emergency Hospital, 011368 Bucharest, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221112
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9689678
OTO - NOTNLM
OT  - MEN1
OT  - angiofibromas
OT  - collagenomas
OT  - endocrine
OT  - gene
OT  - lipomas
OT  - melanoma
OT  - multiple endocrine tumors
OT  - skin
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/27 06:01
PMCR- 2022/11/12
CRDT- 2022/11/26 01:06
PHST- 2022/10/27 00:00 [received]
PHST- 2022/10/27 00:00 [revised]
PHST- 2022/11/07 00:00 [accepted]
PHST- 2022/11/26 01:06 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/27 06:01 [medline]
PHST- 2022/11/12 00:00 [pmc-release]
AID - diagnostics12112768 [pii]
AID - diagnostics-12-02768 [pii]
AID - 10.3390/diagnostics12112768 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 Nov 12;12(11):2768. doi: 10.3390/diagnostics12112768.