PMID- 36430067
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20230119
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 22
DP  - 2022 Nov 20
TI  - Association between Perfluoroalkyl and Polyfluoroalkyl Substances and Women's 
      Infertility, NHANES 2013-2016.
LID - 10.3390/ijerph192215348 [doi]
LID - 15348
AB  - Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are widely used in consumer 
      products. However, the role of PFAS in infertility is still poorly understood. A 
      total of 788 women from the 2013-2016 nationally representative NHANES were 
      included to explore the association between PFAS exposure and self-reported 
      infertility. Six PFAS, including PFDE, PFNA, PFHxS, n-PFOA, n-PFOS, and Sm-PFOS, 
      were detected by online SPE-HPLC-TIS-MS/MS. We used the generalized linear 
      regression model (GLM), generalized additive models (GAM), and Bayesian kernel 
      machine regression (BKMR) to assess the single effects, non-linear relationships, 
      and mixed effects on women's infertility, respectively. The prevalence of 
      self-reported infertility was 15.54% in this study. In GLM, n-PFOA showed a 
      negative association with self-reported infertility in women for the Q3 (OR: 
      0.396, 95% CI: 0.119, 0.788) and Q4 (OR: 0.380, 95% CI: 0.172-0.842) compared 
      with Q1 (p for trend = 0.013). A negative trend was also observed in n-PFOS and 
       summation operatorPFOS (p for trend < 0.05). In GAM, a non-linear relationship was revealed in 
      Sm-PFOS, which exhibits a U-shaped relationship. The BKMR model indicated that 
      there might be a joint effect between PFAS and women's infertility, to which PFNA 
      contributed the highest effect (PIP = 0.435). Moreover, age stratification 
      analysis showed a different dose-response curve in under and above 35 years old. 
      Women under the age of 35 have a more noticeable U-shaped relationship with 
      infertility. Therefore, the relatively low level of mixed PFAS exposure was 
      negatively associated with self-reported infertility in women in general, and the 
      impact of PFAS on infertility may vary among women of different age groups. 
      Further studies are needed to determine the etiological relationship.
FAU - Tan, Yuxuan
AU  - Tan Y
AUID- ORCID: 0000-0002-4535-2750
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
FAU - Zeng, Zurui
AU  - Zeng Z
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
AD  - Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 
      510632, China.
FAU - Liang, Huanzhu
AU  - Liang H
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
FAU - Weng, Xueqiong
AU  - Weng X
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
AD  - Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
FAU - Yao, Huojie
AU  - Yao H
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
FAU - Fu, Yingyin
AU  - Fu Y
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
FAU - Li, Yexin
AU  - Li Y
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
FAU - Chen, Jingmin
AU  - Chen J
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
FAU - Wei, Xiangcai
AU  - Wei X
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
AD  - Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 
      510632, China.
FAU - Jing, Chunxia
AU  - Jing C
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Jinan 
      University, No. 601 Huangpu Ave West, Guangzhou 510632, China.
AD  - Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, 
      Guangzhou 510632, China.
LA  - eng
PT  - Journal Article
DEP - 20221120
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Fluorocarbons)
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Humans
MH  - Female
MH  - Adult
MH  - *Fluorocarbons
MH  - *Alkanesulfonic Acids
MH  - Nutrition Surveys
MH  - *Environmental Pollutants
MH  - Bayes Theorem
MH  - Tandem Mass Spectrometry
MH  - *Infertility
PMC - PMC9692248
OTO - NOTNLM
OT  - Bayesian kernel machine regression (BKMR)
OT  - PFAS
OT  - generalized additive models (GAM)
OT  - generalized linear model (GLM)
OT  - infertility
OT  - mixed effect
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/20
CRDT- 2022/11/26 01:13
PHST- 2022/08/30 00:00 [received]
PHST- 2022/10/27 00:00 [revised]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/11/26 01:13 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/20 00:00 [pmc-release]
AID - ijerph192215348 [pii]
AID - ijerph-19-15348 [pii]
AID - 10.3390/ijerph192215348 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Nov 20;19(22):15348. doi: 
      10.3390/ijerph192215348.