PMID- 36430270 OWN - NLM STAT- MEDLINE DCOM- 20221129 LR - 20221213 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 23 IP - 22 DP - 2022 Nov 9 TI - Pluripotent Stem Cells in Clinical Cell Transplantation: Focusing on Induced Pluripotent Stem Cell-Derived RPE Cell Therapy in Age-Related Macular Degeneration. LID - 10.3390/ijms232213794 [doi] LID - 13794 AB - Human pluripotent stem cells (PSCs), including both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represent valuable cell sources to replace diseased or injured tissues in regenerative medicine. iPSCs exhibit the potential for indefinite self-renewal and differentiation into various cell types and can be reprogrammed from somatic tissue that can be easily obtained, paving the way for cell therapy, regenerative medicine, and personalized medicine. Cell therapies using various iPSC-derived cell types are now evolving rapidly for the treatment of clinical diseases, including Parkinson's disease, hematological diseases, cardiomyopathy, osteoarthritis, and retinal diseases. Since the first interventional clinical trial with autologous iPSC-derived retinal pigment epithelial cells (RPEs) for the treatment of age-related macular degeneration (AMD) was accomplished in Japan, several preclinical trials using iPSC suspensions or monolayers have been launched, or are ongoing or completed. The evolution and generation of human leukocyte antigen (HLA)-universal iPSCs may facilitate the clinical application of iPSC-based therapies. Thus, iPSCs hold great promise in the treatment of multiple retinal diseases. The efficacy and adverse effects of iPSC-based retinal therapies should be carefully assessed in ongoing and further clinical trials. FAU - Yang, Yi-Ping AU - Yang YP AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. AD - Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. FAU - Hsiao, Yu-Jer AU - Hsiao YJ AUID- ORCID: 0000-0002-0783-605X AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. FAU - Chang, Kao-Jung AU - Chang KJ AUID- ORCID: 0000-0002-2238-7387 AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. FAU - Foustine, Shania AU - Foustine S AD - Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. FAU - Ko, Yu-Ling AU - Ko YL AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. FAU - Tsai, Yi-Ching AU - Tsai YC AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. FAU - Tai, Hsiao-Yun AU - Tai HY AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. FAU - Ko, Yu-Chieh AU - Ko YC AUID- ORCID: 0000-0002-0818-4962 AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan. FAU - Chiou, Shih-Hwa AU - Chiou SH AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. AD - Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan. AD - Genomics Research Center, Academia Sinica, Taipei 115201, Taiwan. FAU - Lin, Tai-Chi AU - Lin TC AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan. FAU - Chen, Shih-Jen AU - Chen SJ AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan. FAU - Chien, Yueh AU - Chien Y AUID- ORCID: 0000-0002-1528-9252 AD - Department of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan. AD - Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. FAU - Hwang, De-Kuang AU - Hwang DK AUID- ORCID: 0000-0001-6346-8485 AD - School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112201, Taiwan. LA - eng PT - Journal Article PT - Review DEP - 20221109 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 SB - IM MH - Humans MH - *Induced Pluripotent Stem Cells MH - Retinal Pigment Epithelium/metabolism MH - *Macular Degeneration/therapy/metabolism MH - Cell- and Tissue-Based Therapy MH - *Retinal Diseases/metabolism MH - Cell Transplantation PMC - PMC9696562 OTO - NOTNLM OT - age-related macular degeneration OT - cell transplantation OT - clinical trials OT - embryonic stem cells OT - induced pluripotent stem cell OT - pluripotent stem cells OT - retinal pigment epithelial cells COIS- The authors declare no conflict of interest. EDAT- 2022/11/27 06:00 MHDA- 2022/11/30 06:00 PMCR- 2022/11/09 CRDT- 2022/11/26 01:15 PHST- 2022/10/03 00:00 [received] PHST- 2022/11/02 00:00 [revised] PHST- 2022/11/03 00:00 [accepted] PHST- 2022/11/26 01:15 [entrez] PHST- 2022/11/27 06:00 [pubmed] PHST- 2022/11/30 06:00 [medline] PHST- 2022/11/09 00:00 [pmc-release] AID - ijms232213794 [pii] AID - ijms-23-13794 [pii] AID - 10.3390/ijms232213794 [doi] PST - epublish SO - Int J Mol Sci. 2022 Nov 9;23(22):13794. doi: 10.3390/ijms232213794.