PMID- 36430301
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20221213
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 22
DP  - 2022 Nov 10
TI  - Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber 
      Fate in Sarcopenia.
LID - 10.3390/ijms232213823 [doi]
LID - 13823
AB  - The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte 
      viability. The signaling pathways triggered by mTOR vary according to the type of 
      endogenous and exogenous factors (e.g., redox balance, nutrient availability, 
      physical activity) as well as organismal age. Here, we provide an overview of 
      mTOR signaling in skeletal muscle, with a special focus on the role played by 
      mTOR in the development of sarcopenia. Intervention strategies targeting mTOR in 
      sarcopenia (e.g., supplementation of plant extracts, hormones, inorganic ions, 
      calorie restriction, and exercise) have also been discussed.
FAU - Sirago, Giuseppe
AU  - Sirago G
AUID- ORCID: 0000-0001-7005-8708
AD  - Department of Biomedical Sciences, Universita degli Studi di Padova, 35131 Padua, 
      Italy.
FAU - Picca, Anna
AU  - Picca A
AUID- ORCID: 0000-0001-7032-3487
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
AD  - Department of Medicine and Surgery, LUM University, 70100 Casamassima, Italy.
FAU - Calvani, Riccardo
AU  - Calvani R
AUID- ORCID: 0000-0001-5472-2365
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
FAU - Coelho-Junior, Helio Jose
AU  - Coelho-Junior HJ
AUID- ORCID: 0000-0001-7482-9514
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
AD  - Department of Geriatrics and Orthopedics, Universita Cattolica del Sacro Cuore, 
      00168 Roma, Italy.
FAU - Marzetti, Emanuele
AU  - Marzetti E
AUID- ORCID: 0000-0001-9567-6983
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
AD  - Department of Geriatrics and Orthopedics, Universita Cattolica del Sacro Cuore, 
      00168 Roma, Italy.
LA  - eng
GR  - D1.2020/Catholic University of the Sacred Heart/
GR  - D1.2022/Catholic University of the Sacred Heart/
GR  - Not applicable/Centro Studi Achille e Linda Lorenzon/
PT  - Journal Article
PT  - Review
DEP - 20221110
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - W36ZG6FT64 (Sirolimus)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Humans
MH  - Muscle Fibers, Skeletal/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - *Sarcopenia/metabolism
MH  - Signal Transduction/physiology
MH  - Sirolimus
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Animals
PMC - PMC9696247
OTO - NOTNLM
OT  - aging
OT  - atrogenes
OT  - autophagy
OT  - calorie restriction
OT  - mitophagy
OT  - neuromuscular junction
OT  - protein degradation
OT  - protein synthesis
OT  - rapalogs
OT  - skeletal muscle
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/10
CRDT- 2022/11/26 01:15
PHST- 2022/10/17 00:00 [received]
PHST- 2022/11/02 00:00 [revised]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/11/26 01:15 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/10 00:00 [pmc-release]
AID - ijms232213823 [pii]
AID - ijms-23-13823 [pii]
AID - 10.3390/ijms232213823 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Nov 10;23(22):13823. doi: 10.3390/ijms232213823.