PMID- 36430565
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221213
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 22
DP  - 2022 Nov 15
TI  - Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via 
      Suppression of Fibroblast-to-Myofibroblast Differentiation.
LID - 10.3390/ijms232214088 [doi]
LID - 14088
AB  - Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal 
      interstitial lung disease with unknown etiology. Despite substantial progress in 
      understanding the pathogenesis of pulmonary fibrosis and drug development, there 
      is still no cure for this devastating disease. Fenbendazole (FBZ) is a 
      benzimidazole compound that is widely used as an anthelmintic agent and recent 
      studies have expanded the scope of its pharmacological effects and application 
      prospect. This study demonstrated that FBZ treatment blunted bleomycin-induced 
      lung fibrosis in mice. In vitro studies showed that FBZ inhibited the 
      proliferation and migration of human embryo lung fibroblasts. Further studies 
      showed that FBZ significantly inhibited glucose consumption, moderated glycolytic 
      metabolism in fibroblasts, thus activated adenosine monophosphate-activated 
      protein kinase (AMPK), and reduced the activation of the mammalian target of 
      rapamycin (mTOR) pathway, thereby inhibiting transforming growth factor-beta 
      (TGF-beta1)-induced fibroblast-to-myofibroblast differentiation and collagen 
      synthesis. In summary, our data suggested that FBZ has potential as a novel 
      treatment for pulmonary fibrosis.
FAU - Wang, Lan
AU  - Wang L
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Xu, Kai
AU  - Xu K
AUID- ORCID: 0000-0001-8763-8100
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Wang, Ningdan
AU  - Wang N
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Ding, Linke
AU  - Ding L
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Zhao, Wenyu
AU  - Zhao W
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Wan, Ruyan
AU  - Wan R
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Zhao, Weiming
AU  - Zhao W
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Guo, Xiaoshu
AU  - Guo X
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Pan, Xin
AU  - Pan X
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Yang, Juntang
AU  - Yang J
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
FAU - Rosas, Ivan
AU  - Rosas I
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of 
      Medicine, Houston, TX 77030, USA.
FAU - Yu, Guoying
AU  - Yu G
AD  - State Key Laboratory Cell Differentiation and Regulation, Henan International 
      Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas 
      Scientists of Pulmonary Fibrosis, College of Life Science, Institute of 
      Biomedical Science, Henan Normal University, Xinxiang 453007, China.
LA  - eng
PT  - Journal Article
DEP - 20221115
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 11056-06-7 (Bleomycin)
RN  - 621BVT9M36 (Fenbendazole)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Bleomycin/adverse effects
MH  - Fenbendazole
MH  - Myofibroblasts
MH  - Fibroblasts
MH  - *Idiopathic Pulmonary Fibrosis
MH  - Mammals
PMC - PMC9693227
OTO - NOTNLM
OT  - AMPK
OT  - fenbendazole
OT  - fibroblasts
OT  - glycolysis
OT  - pulmonary fibrosis
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/15
CRDT- 2022/11/26 01:17
PHST- 2022/10/11 00:00 [received]
PHST- 2022/11/07 00:00 [revised]
PHST- 2022/11/12 00:00 [accepted]
PHST- 2022/11/26 01:17 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/15 00:00 [pmc-release]
AID - ijms232214088 [pii]
AID - ijms-23-14088 [pii]
AID - 10.3390/ijms232214088 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Nov 15;23(22):14088. doi: 10.3390/ijms232214088.