PMID- 36430714
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221213
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 22
DP  - 2022 Nov 17
TI  - Therapeutic Efficacy of Natural Product 'C-Phycocyanin' in Alleviating 
      Streptozotocin-Induced Diabetes via the Inhibition of Glycation Reaction in Rats.
LID - 10.3390/ijms232214235 [doi]
LID - 14235
AB  - Diabetes is a long-term metabolic disorder characterized by persistently elevated 
      blood sugar levels. Chronic hyperglycemia enhances glucose-protein interactions, 
      leading to the formation of advanced glycation end products (AGEs), which form 
      irreversible cross-links with a wide variety of macromolecules, and accumulate 
      rapidly in the body tissues. Thus, the objective of this study was to assess the 
      therapeutic properties of C-phycocyanin (C-PC) obtained from Plectonema species 
      against oxidative stress, glycation, and type 2 diabetes mellitus (T2DM) in a 
      streptozotocin (STZ)-induced diabetic Wistar rat. Forty-five days of C-PC 
      administration decreased levels of triglycerides (TGs), blood glucose, 
      glycosylated hemoglobin, (HbA1c), total cholesterol (TC), low-density lipoprotein 
      cholesterol (LDL-C), liver and kidney function indices, and raised body weight in 
      diabetic rats. C-PC suppressed biochemical glycation markers, as well as serum 
      carboxymethyllysine (CML) and fluorescent AGEs. Additionally, C-PC maintained the 
      redox state by lowering lipid peroxidation and protein-bound carbonyl content 
      (CC), enhancing the activity of high-density lipoprotein cholesterol (HDL-C) and 
      renal antioxidant enzymes, and preserving retinal and renal histopathological 
      characteristics. Thus, we infer that C-PC possesses antidiabetic and 
      antiglycation effects in diabetic rats. C-PC may also act as an antidiabetic and 
      antiglycation agent in vivo that may reduce the risk of secondary diabetic 
      complications.
FAU - Husain, Arbab
AU  - Husain A
AUID- ORCID: 0000-0002-9487-9284
AD  - Department of Biosciences, Faculty of Sciences, Integral University, Lucknow 
      226026, India.
AD  - Department of Biotechnology and Life Sciences, Institute of Biomedical Education 
      and Research, Mangalayatan University, Aligarh 202145, India.
FAU - Alouffi, Sultan
AU  - Alouffi S
AUID- ORCID: 0000-0003-3443-9700
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Sciences, 
      University of Hail, Hail 2440, Saudi Arabia.
AD  - Molecular Diagnostic & Personalized Therapeutic Unit, University of Hail, Hail 
      2440, Saudi Arabia.
FAU - Khanam, Afreen
AU  - Khanam A
AD  - Department of Biosciences, Faculty of Sciences, Integral University, Lucknow 
      226026, India.
AD  - Department of Biotechnology and Life Sciences, Institute of Biomedical Education 
      and Research, Mangalayatan University, Aligarh 202145, India.
FAU - Akasha, Rihab
AU  - Akasha R
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Sciences, 
      University of Hail, Hail 2440, Saudi Arabia.
FAU - Farooqui, Alvina
AU  - Farooqui A
AD  - Department of Bioengineering, Faculty of Engineering, Integral University, 
      Lucknow 226026, India.
FAU - Ahmad, Saheem
AU  - Ahmad S
AUID- ORCID: 0000-0003-1215-0279
AD  - Department of Medical Laboratory Sciences, College of Applied Medical Sciences, 
      University of Hail, Hail 2440, Saudi Arabia.
AD  - Molecular Diagnostic & Personalized Therapeutic Unit, University of Hail, Hail 
      2440, Saudi Arabia.
LA  - eng
GR  - RG-21069/University of Hail/
PT  - Journal Article
DEP - 20221117
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 5W494URQ81 (Streptozocin)
RN  - 11016-15-2 (Phycocyanin)
RN  - 0 (Biological Products)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - Streptozocin
MH  - Phycocyanin/pharmacology/therapeutic use
MH  - *Biological Products/therapeutic use
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Rats, Wistar
MH  - Hypoglycemic Agents/pharmacology/therapeutic use
MH  - *Hyperglycemia/drug therapy
MH  - Cholesterol, HDL
PMC - PMC9698742
OTO - NOTNLM
OT  - Plectonema species
OT  - advanced glycation end products (AGEs)
OT  - c-phycocyanin (C-PC)
OT  - streptozotocin (STZ)
OT  - type 2 diabetes mellitus (T2DM)
COIS- The authors declare no conflict of interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/17
CRDT- 2022/11/26 01:18
PHST- 2022/08/31 00:00 [received]
PHST- 2022/11/01 00:00 [revised]
PHST- 2022/11/03 00:00 [accepted]
PHST- 2022/11/26 01:18 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/17 00:00 [pmc-release]
AID - ijms232214235 [pii]
AID - ijms-23-14235 [pii]
AID - 10.3390/ijms232214235 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Nov 17;23(22):14235. doi: 10.3390/ijms232214235.