PMID- 36431890
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221213
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 22
DP  - 2022 Nov 12
TI  - Exosomes as Novel Delivery Systems for Application in Traditional Chinese 
      Medicine.
LID - 10.3390/molecules27227789 [doi]
LID - 7789
AB  - Exosomes, as gifts of nature derived from various cell types with a size range 
      from ~40 to 160 nm in diameter, have gained attention recently. They are composed 
      of a lipid membrane bilayer structure containing different constituents, such as 
      surface ligands and receptors, from the parental cells. Originating from a 
      variety of sources, exosomes have the ability to participate in a diverse range 
      of biological processes, including the regulation of cellular communication. On 
      account of their ideal native structure and characteristics, exosomes are taken 
      into account as drug delivery systems (DDSs). They can provide profound effects 
      on conveying therapeutic agents with great advantages, including specific 
      targeting, high biocompatibility, and non-toxicity. Further, they can also be 
      considered to ameliorate natural compounds, the main constituents of traditional 
      Chinese medicine (TCM), which are usually ignored due to the complexity of their 
      structures, poor stability, and unclear mechanisms of action. This review 
      summarizes the classification of exosomes as well as the research progress on 
      exosome-based DDSs for the treatment of different diseases in TCM. Furthermore, 
      this review discusses the advantages and challenges faced by exosomes to 
      contribute to their further investigation and application.
FAU - Chen, Qi
AU  - Chen Q
AUID- ORCID: 0000-0002-5152-0079
AD  - Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang 
      Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 
      Hangzhou 310053, China.
FAU - Wu, Di
AU  - Wu D
AD  - Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang 
      Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 
      Hangzhou 310053, China.
FAU - Wang, Yi
AU  - Wang Y
AUID- ORCID: 0000-0002-1350-2961
AD  - Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang 
      Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 
      Hangzhou 310053, China.
AD  - Department of Neurology, The Third Affiliated Hospital, Zhejiang Chinese Medical 
      University, Hangzhou 310053, China.
FAU - Chen, Zhong
AU  - Chen Z
AUID- ORCID: 0000-0003-4755-9357
AD  - Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang 
      Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 
      Hangzhou 310053, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221112
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
SB  - IM
MH  - *Exosomes/metabolism
MH  - Medicine, Chinese Traditional
MH  - Drug Delivery Systems
MH  - Cell Communication/physiology
PMC - PMC9695524
OTO - NOTNLM
OT  - drug delivery systems
OT  - exosomes
OT  - nanoparticle
OT  - traditional Chinese medicine
COIS- The authors declare no conflict of interest. Figures were created with BioRender 
      Software, ©biorender.com.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/12
CRDT- 2022/11/26 01:26
PHST- 2022/10/12 00:00 [received]
PHST- 2022/11/08 00:00 [revised]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2022/11/26 01:26 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/12 00:00 [pmc-release]
AID - molecules27227789 [pii]
AID - molecules-27-07789 [pii]
AID - 10.3390/molecules27227789 [doi]
PST - epublish
SO  - Molecules. 2022 Nov 12;27(22):7789. doi: 10.3390/molecules27227789.