PMID- 36432247 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221213 IS - 2079-4991 (Print) IS - 2079-4991 (Electronic) IS - 2079-4991 (Linking) VI - 12 IP - 22 DP - 2022 Nov 10 TI - Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetron Sputtering. LID - 10.3390/nano12223962 [doi] LID - 3962 AB - Antibacterial properties of engineered materials are important in the transition to a circular economy and societal security, as they are central to many key industrial areas, such as health, food, and water treatment/reclaiming. Nanocoating and electrospinning are two versatile, simple, and low-cost technologies that can be combined into new advanced manufacturing approaches to achieve controlled production of innovative micro- and nano-structured non-woven membranes with antifouling and antibacterial properties. The present study investigates a rational approach to design and manufacture electrospun membranes of polysulfone (PSU) with mechanical properties optimized via combinatorial testing from factorial design of experiments (DOE) and endowed with antimicrobial silver (Ag) nanocoating. Despite the very low amount of Ag deposited as a conformal percolating nanocoating web on the polymer fibers, the antimicrobial resistance assessed against the Gram-negative bacteria E. coli proved to be extremely effective, almost completely inhibiting the microbial proliferation with respect to the reference uncoated PSU membrane. The results are relevant, for example, to improve antifouling behavior in ultrafiltration and reverse osmosis in water treatment. FAU - Fiaschini, Noemi AU - Fiaschini N AUID- ORCID: 0000-0003-1094-7743 AD - NANOFABER S.r.l., Via Anguillarese 301, 00123 Rome, Italy. FAU - Giuliani, Chiara AU - Giuliani C AD - SSPT-PROMAS-MATPRO, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Via Anguillarese 301, 00123 Rome, Italy. FAU - Vitali, Roberta AU - Vitali R AD - SSPT-TECS-TEB, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Via Anguillarese 301, 00123 Rome, Italy. FAU - Tammaro, Loredana AU - Tammaro L AUID- ORCID: 0000-0002-7948-8103 AD - SSPT-PROMAS-NANO, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Piazzale E. Fermi, 1, Portici, 80055 Napoli, Italy. FAU - Valerini, Daniele AU - Valerini D AUID- ORCID: 0000-0003-0472-210X AD - SSPT-PROMAS-MATAS, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, S.S. 7 Appia, km 706, 72100 Brindisi, Italy. FAU - Rinaldi, Antonio AU - Rinaldi A AUID- ORCID: 0000-0002-3087-2649 AD - SSPT-PROMAS-MATPRO, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Via Anguillarese 301, 00123 Rome, Italy. LA - eng GR - 862100/NEWSKIN Project/ PT - Journal Article DEP - 20221110 PL - Switzerland TA - Nanomaterials (Basel) JT - Nanomaterials (Basel, Switzerland) JID - 101610216 PMC - PMC9698612 OTO - NOTNLM OT - antibacterial OT - antifouling OT - antimicrobial OT - biomedical OT - electrospinning OT - magnetron sputtering OT - nanocoating OT - polysulfone (PSU) OT - silver nanoparticles OT - water filtration COIS- The authors declare no conflict of interest. EDAT- 2022/11/27 06:00 MHDA- 2022/11/27 06:01 PMCR- 2022/11/10 CRDT- 2022/11/26 01:29 PHST- 2022/10/18 00:00 [received] PHST- 2022/11/04 00:00 [revised] PHST- 2022/11/06 00:00 [accepted] PHST- 2022/11/26 01:29 [entrez] PHST- 2022/11/27 06:00 [pubmed] PHST- 2022/11/27 06:01 [medline] PHST- 2022/11/10 00:00 [pmc-release] AID - nano12223962 [pii] AID - nanomaterials-12-03962 [pii] AID - 10.3390/nano12223962 [doi] PST - epublish SO - Nanomaterials (Basel). 2022 Nov 10;12(22):3962. doi: 10.3390/nano12223962.