PMID- 36432494
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221213
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 22
DP  - 2022 Nov 13
TI  - Avicularin Attenuates Lead-Induced Impairment of Hepatic Glucose Metabolism by 
      Inhibiting the ER Stress-Mediated Inflammatory Pathway.
LID - 10.3390/nu14224806 [doi]
LID - 4806
AB  - Lead (Pb), an environmental hazard, causes several human diseases. Avicularin 
      (Avi), a main dietary flavonoid found in several plants and fruits, exhibits 
      potential protective properties on organs. However, the molecular mechanisms of 
      Avi's protective effects against Pb-induced damage are not clear. In our study, 
      the effects of Avi on Pb-induced hepatotoxicity were evaluated using ICR mice. We 
      have revealed for the first time that treatment with Avi significantly reduced 
      hepatic inflammation, endoplasmic reticulum stress (ERS) and glucose metabolism 
      disorder induced by Pb. Avi decreased the serum biochemical indicators of glucose 
      metabolism. Avi increased the activities of glycogenolysis rate-limiting enzyme 
      hexokinase (HK), pyruvate kinase (PK), glucokinase (GK) and glycogen 
      phosphorylase (PYG) and inhibited the activities of gluconeogenesis rate-limiting 
      enzyme phosphoenolpyruvate carboxy kinase (PEPCK) and glucose-6-phosphate 
      dehydrogenase (G6PD). Avi decreased the protein expression levels of 
      glucose-regulated protein 78 (GRP78), phosphorylated inositol requiring enzyme 1 
      (p-IRE1), phosphorylated RNA-dependent protein kinase-like ER kinase (p-PERK) and 
      phosphorylated eukaryotic initiation factor 2alpha (p-eIF2alpha). The levels of tumor 
      necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were decreased in the 
      liver as a result of Avi suppression Pb-induced inflammation. These results 
      indicated that Avi attenuated Pb-induced impairment of hepatic glucose metabolism 
      by the ERS and inflammation pathway.
FAU - Qiu, Ting
AU  - Qiu T
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
FAU - Shi, Jia-Xue
AU  - Shi JX
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
FAU - Cheng, Chao
AU  - Cheng C
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
FAU - Jiang, Hong
AU  - Jiang H
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
FAU - Ruan, Hai-Nan
AU  - Ruan HN
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
FAU - Li, Jun
AU  - Li J
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
FAU - Liu, Chan-Min
AU  - Liu CM
AUID- ORCID: 0000-0001-7343-3884
AD  - School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, 
      Tongshan New Area, Xuzhou 221116, China.
LA  - eng
GR  - 31972942/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20221113
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - IY9XDZ35W2 (Glucose)
RN  - 572-30-5 (avicularin)
RN  - 2P299V784P (Lead)
RN  - 0 (Flavonoids)
RN  - 0 (Eukaryotic Initiation Factor-2)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Humans
MH  - *Endoplasmic Reticulum Stress
MH  - *Glucose/metabolism
MH  - Lead/metabolism
MH  - Mice, Inbred ICR
MH  - Liver/metabolism
MH  - Flavonoids/pharmacology
MH  - Eukaryotic Initiation Factor-2/metabolism
MH  - Inflammation/metabolism
PMC - PMC9697143
OTO - NOTNLM
OT  - avicularin
OT  - endoplasmic reticulum stress
OT  - glucose metabolism
OT  - inflammation
OT  - lead
OT  - liver damage
COIS- The authors declare no competing financial interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/13
CRDT- 2022/11/26 01:30
PHST- 2022/10/19 00:00 [received]
PHST- 2022/11/05 00:00 [revised]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/11/26 01:30 [entrez]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/13 00:00 [pmc-release]
AID - nu14224806 [pii]
AID - nutrients-14-04806 [pii]
AID - 10.3390/nu14224806 [doi]
PST - epublish
SO  - Nutrients. 2022 Nov 13;14(22):4806. doi: 10.3390/nu14224806.