PMID- 36435242
OWN - NLM
STAT- MEDLINE
DCOM- 20221214
LR  - 20221222
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 859
IP  - Pt 2
DP  - 2023 Feb 10
TI  - Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish 
      (Danio rerio) larvae.
PG  - 160457
LID - S0048-9697(22)07559-3 [pii]
LID - 10.1016/j.scitotenv.2022.160457 [doi]
AB  - Anthropogenic releases of plastics, persistent organic pollutants (POPs), and 
      heavy metals can impact the environment, including aquatic ecosystems. 
      Nanoplastics (NPs) have recently emerged as pervasive environmental pollutants 
      that have the ability to adsorb POPs and can cause stress in organisms. Among 
      POPs, DDT and its metabolites are ubiquitous environmental pollutants due to 
      their long persistence. Despite the discontinued use of DDT in Europe, DDT and 
      its metabolites (primarily p,p'-DDE) are still found at detectable levels in fish 
      feed used in salmon aquaculture. Our study aimed to look at the individual and 
      combined toxicity of NPs (50 mg/L polystyrene) and DDE (100 mug/L) using zebrafish 
      larvae as a model. We found no significant morphological, cardiac, respiratory, 
      or behavioural changes in zebrafish larvae exposed to NPs alone. Conversely, 
      morphological, cardiac and respiratory alterations were observed in zebrafish 
      larvae exposed to DDE and NPs + DDE. Interestingly, behavioural changes were only 
      observed in zebrafish larvae exposed to NPs + DDE. These findings were supported 
      by RNA-seq results, which showed that some cardiac, vascular, and immunogenic 
      pathways were downregulated only in zebrafish larvae exposed to NPs + DDE. In 
      summary, we found an enhanced toxicological impact of DDE when combined with NPs.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Varshney, Shubham
AU  - Varshney S
AD  - Faculty of Biosciences and Aquaculture, Nord University, Bodo, Norway.
FAU - Gora, Adnan H
AU  - Gora AH
AD  - Faculty of Biosciences and Aquaculture, Nord University, Bodo, Norway.
FAU - Kiron, Viswanath
AU  - Kiron V
AD  - Faculty of Biosciences and Aquaculture, Nord University, Bodo, Norway.
FAU - Siriyappagouder, Prabhugouda
AU  - Siriyappagouder P
AD  - Faculty of Biosciences and Aquaculture, Nord University, Bodo, Norway.
FAU - Dahle, Dalia
AU  - Dahle D
AD  - Faculty of Biosciences and Aquaculture, Nord University, Bodo, Norway.
FAU - Kogel, Tanja
AU  - Kogel T
AD  - Institute of Marine Research, Bergen, Norway; Faculty of Mathematics and Natural 
      Sciences, University of Bergen, Norway.
FAU - Ornsrud, Robin
AU  - Ornsrud R
AD  - Institute of Marine Research, Bergen, Norway.
FAU - Olsvik, Pal A
AU  - Olsvik PA
AD  - Faculty of Biosciences and Aquaculture, Nord University, Bodo, Norway; Institute 
      of Marine Research, Bergen, Norway. Electronic address: pal.a.olsvik@nord.no.
LA  - eng
PT  - Journal Article
DEP - 20221123
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Polystyrenes)
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Animals
MH  - Zebrafish/metabolism
MH  - Larva
MH  - Polystyrenes/toxicity/metabolism
MH  - Ecosystem
MH  - *Water Pollutants, Chemical/metabolism
MH  - *Environmental Pollutants/metabolism
OTO - NOTNLM
OT  - Behavioural toxicity
OT  - Cardiotoxicity
OT  - DDT
OT  - DanioVision system
OT  - Respiration
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2022/11/27 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/11/26 19:24
PHST- 2022/09/21 00:00 [received]
PHST- 2022/11/15 00:00 [revised]
PHST- 2022/11/20 00:00 [accepted]
PHST- 2022/11/27 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/11/26 19:24 [entrez]
AID - S0048-9697(22)07559-3 [pii]
AID - 10.1016/j.scitotenv.2022.160457 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Feb 10;859(Pt 2):160457. doi: 
      10.1016/j.scitotenv.2022.160457. Epub 2022 Nov 23.