PMID- 36436278
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230201
IS  - 1873-5711 (Electronic)
IS  - 1050-6411 (Linking)
VI  - 68
DP  - 2023 Feb
TI  - Differences in motor unit behavior during isometric contractions in patients with 
      diabetic peripheral neuropathy at various disease severities.
PG  - 102725
LID - S1050-6411(22)00098-0 [pii]
LID - 10.1016/j.jelekin.2022.102725 [doi]
AB  - The aim of this study was to determine whether HD-sEMG is sensitive to detecting 
      changes in motor unit behavior amongst healthy adults and type 2 diabetes 
      mellitus (T2DM) patients presenting diabetic peripheral neuropathy (DPN) at 
      different levels. Healthy control subjects (CON, n = 8) and T2DM patients 
      presenting no DPN symptoms (ABS, n = 8), moderate DPN (MOD, n = 18), and severe 
      DPN (SEV, n = 12) performed isometric ankle dorsiflexion at 30 % maximum 
      voluntary contraction while high-density surface EMG (HD-sEMG) was recorded from 
      the tibialis anterior muscle. HD-sEMG signals were decomposed, providing 
      estimates of discharge rate, motor unit conduction velocity (MUCV), and motor 
      unit territory area (MUTA). As a result, the ABS group presented reduced MUCV 
      compared to CON. The groups with diabetes presented significantly larger MUTA 
      compared to the CON group (p < 0.01), and the SEV group presented a significantly 
      lower discharge rate compared to CON and ABS (p < 0.01). In addition, the SEV 
      group presented significantly higher CoV(force) compared to CON and MOD. These 
      results support the use of HD-SEMG as a method to detect peripheral and central 
      changes related to DPN.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Favretto, Mateus Andre
AU  - Favretto MA
AD  - Institute of Biomedical Engineering, Department of Electrical and Electronic 
      Engineering, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 
      Brazil. Electronic address: mateus_favretto@hotmail.com.
FAU - Andreis, Felipe Rettore
AU  - Andreis FR
AD  - Center for Neuroplasticity and Pain (CNAP), Department of Health Science and 
      Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
FAU - Cossul, Sandra
AU  - Cossul S
AD  - Institute of Biomedical Engineering, Department of Electrical and Electronic 
      Engineering, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 
      Brazil.
FAU - Negro, Francesco
AU  - Negro F
AD  - Department of Clinical and Experimental Sciences, Universita degli Studi di 
      Brescia, Brescia, Italy.
FAU - Oliveira, Anderson Souza
AU  - Oliveira AS
AD  - Department of Materials and Production, Aalborg University, Aalborg, Denmark.
FAU - Marques, Jefferson Luiz Brum
AU  - Marques JLB
AD  - Institute of Biomedical Engineering, Department of Electrical and Electronic 
      Engineering, Federal University of Santa Catarina, Florianopolis, Santa Catarina, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20221121
PL  - England
TA  - J Electromyogr Kinesiol
JT  - Journal of electromyography and kinesiology : official journal of the 
      International Society of Electrophysiological Kinesiology
JID - 9109125
SB  - IM
MH  - Adult
MH  - Humans
MH  - Muscle, Skeletal/physiology
MH  - Isometric Contraction/physiology
MH  - *Diabetic Neuropathies/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Electromyography/methods
OTO - NOTNLM
OT  - Conduction velocity
OT  - Diabetic peripheral neuropathy
OT  - Discharge rate
OT  - High-density surface electromyography
OT  - Motor Unit
OT  - Motor unit territory area
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/28 06:00
MHDA- 2023/01/25 06:00
CRDT- 2022/11/27 18:08
PHST- 2021/12/29 00:00 [received]
PHST- 2022/09/14 00:00 [revised]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/11/28 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2022/11/27 18:08 [entrez]
AID - S1050-6411(22)00098-0 [pii]
AID - 10.1016/j.jelekin.2022.102725 [doi]
PST - ppublish
SO  - J Electromyogr Kinesiol. 2023 Feb;68:102725. doi: 10.1016/j.jelekin.2022.102725. 
      Epub 2022 Nov 21.