PMID- 36436685
OWN - NLM
STAT- MEDLINE
DCOM- 20230103
LR  - 20230626
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 372
DP  - 2023 Feb 1
TI  - Prevalence and determinants of tricuspid regurgitation after repair of tetralogy 
      of Fallot.
PG  - 55-59
LID - S0167-5273(22)01726-0 [pii]
LID - 10.1016/j.ijcard.2022.11.039 [doi]
AB  - BACKGROUND: The prevalence and determinants of tricuspid regurgitation (TR) in 
      patients with repaired Tetralogy of Fallot (rTOF) remain incompletely understood. 
      OBJECTIVES: To explore the prevalence of and factors associated with TR in 
      patients with rTOF, specifically, the relationship of right ventricular (RV) 
      dilatation with TR severity. METHODS: Patients (>/=17 yrs) with rTOF referred to 
      our service (2000-2019) were identified. Those with severe pulmonary stenosis, 
      significant shunt, or previous tricuspid valve surgery were excluded. Using 
      standard cardiac MRI protocols, RV, right atrial (RA) and tricuspid valve (TV) 
      parameters were measured and compared. RESULTS: 68 consecutively eligible 
      patients with rTOF were included in the study (27 +/- 9 yrs., 35% female). Despite 
      substantial RV volume overload (mean RVEDVi 153 mL/m(2)), the majority of the 
      cohort (78%) had no or only mild TR. RA volumes, tenting height/area and annular 
      diameter were normal (4.9 +/- 2.0 mm, 1.1 +/- 1.0 cm(2) and 32.4 +/- 6.2 mm, 
      respectively). There was no significant correlation of TR fraction with RVEDVi 
      (r = 0.13; p = 0.30), RVEF (r = 0.09; p = 0.44) or tricuspid annular diameter 
      (r = 0.07; p = 0.62). Only RAVi showed a weak but significant correlation with TR 
      fraction (0.29; p = 0.03). In a pooled cohort analysis, including both rTOF 
      patients and adults with a dilated RV from pre-tricuspid shunt lesions, only rTOF 
      was independently associated with higher TR fraction (p = 0.017). CONCLUSION: 
      Despite substantial RV dilatation in a cohort with rTOF, there was surprisingly 
      little TR. We found poor correlation between RVEDVi, RA volumes, tricuspid 
      annular dilatation and the presence of significant TR. These findings question 
      commonly held notions regarding the pathophysiology of functional TR in these 
      patients.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Offen, Sophie
AU  - Offen S
AD  - Faculty of Medicine and Health, University of Sydney, Australia; Department of 
      Cardiology, Royal Prince Alfred Hospital, Australia.
FAU - Puranik, Raj
AU  - Puranik R
AD  - Faculty of Medicine and Health, University of Sydney, Australia; Department of 
      Cardiology, Royal Prince Alfred Hospital, Australia.
FAU - Baker, David
AU  - Baker D
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Australia.
FAU - Cordina, Rachael
AU  - Cordina R
AD  - Faculty of Medicine and Health, University of Sydney, Australia; Department of 
      Cardiology, Royal Prince Alfred Hospital, Australia.
FAU - Chard, Richard
AU  - Chard R
AD  - Department of Cardiology, Westmead Hospital, Australia.
FAU - Celermajer, David S
AU  - Celermajer DS
AD  - Faculty of Medicine and Health, University of Sydney, Australia; Department of 
      Cardiology, Royal Prince Alfred Hospital, Australia; Heart Research Institute, 
      Australia. Electronic address: David.Celermajer@health.nsw.gov.au.
LA  - eng
PT  - Journal Article
DEP - 20221124
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2023 Aug 15;385:22. PMID: 37187328
MH  - Adult
MH  - Humans
MH  - Female
MH  - Male
MH  - *Tricuspid Valve Insufficiency/diagnostic imaging/epidemiology/etiology
MH  - *Tetralogy of Fallot/diagnostic imaging/epidemiology/surgery
MH  - Prevalence
MH  - *Pulmonary Valve Stenosis/complications
MH  - Tricuspid Valve/diagnostic imaging
MH  - Cardiomegaly
MH  - *Pulmonary Valve Insufficiency/surgery
MH  - *Ventricular Dysfunction, Right
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Functional tricuspid regurgitation
OT  - Right ventricle
EDAT- 2022/11/28 06:00
MHDA- 2023/01/04 06:00
CRDT- 2022/11/27 19:25
PHST- 2022/07/18 00:00 [received]
PHST- 2022/11/16 00:00 [revised]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/11/28 06:00 [pubmed]
PHST- 2023/01/04 06:00 [medline]
PHST- 2022/11/27 19:25 [entrez]
AID - S0167-5273(22)01726-0 [pii]
AID - 10.1016/j.ijcard.2022.11.039 [doi]
PST - ppublish
SO  - Int J Cardiol. 2023 Feb 1;372:55-59. doi: 10.1016/j.ijcard.2022.11.039. Epub 2022 
      Nov 24.