PMID- 36437825
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2022
DP  - 2022
TI  - Bushen Wenyang Huayu Decoction Targets TLR4/NF-kappaB Mediated Autophagy to Treat 
      Endometriosis Effectively.
PG  - 4263417
LID - 10.1155/2022/4263417 [doi]
LID - 4263417
AB  - Endometriosis has been found to be closely related to autophagy. This study aimed 
      to elucidate the possible mechanism of Bushen Wenyang Huayu Decoction (BWHD) in 
      treating endometriosis (EMs) by targeting TLR4/NF-kappaB-mediated autophagy. 
      Autologous grafting was used to generate the EMs model in rats. Once the model 
      was developed, BWHD high-dose and low-dose groups received intragastric 
      administration of BWHD, and the gestrinone group served as a positive control. 
      Immunofluorescence labeling and Western blotting were used for the protein 
      expression of toll-like receptor 4 (TLR4), nuclear transcription factor-kappaB 
      (NF-kappaB), Beclin-1, and selective autophagy connector protein P62 (P62). 
      Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze 
      mRNA levels of TLR4, NF-kappaB, Beclin-1, and P62. We found that BWHD significantly 
      reduced the size of ectopic lesions in rats with EMs, regulated reproductive 
      hormone levels, and alleviated the cell autophagy level. It suggested that BWHD 
      could be an effective treatment of EMs by targeting TLR4/NF-kappaB signaling pathway.
CI  - Copyright (c) 2022 Ying Li et al.
FAU - Li, Ying
AU  - Li Y
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Meng, Xin
AU  - Meng X
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Fu, Xinping
AU  - Fu X
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - An, Mingli
AU  - An M
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Liu, Huimin
AU  - Liu H
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Ma, Yiming
AU  - Ma Y
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Li, Qingxue
AU  - Li Q
AD  - Department of Gynecology, The Fourth Hospital of Shijiazhuang, Shijiazhuang 
      050011, China.
FAU - Hao, Guorong
AU  - Hao G
AD  - Department of Gynecology, The Fourth Hospital of Shijiazhuang, Shijiazhuang 
      050011, China.
FAU - Ma, Yucong
AU  - Ma Y
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Zhang, Yu
AU  - Zhang Y
AUID- ORCID: 0000-0002-0101-088X
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
FAU - Yang, Jian
AU  - Yang J
AD  - Department of Rehabilitation, Youfu Hospital of Hebei Province, Shijiazhuang 
      050051, China.
FAU - Chen, Jingwei
AU  - Chen J
AUID- ORCID: 0000-0002-7791-9053
AD  - Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Institute 
      of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 
      050200, China.
LA  - eng
PT  - Journal Article
DEP - 20221118
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC9699773
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/11/18
CRDT- 2022/11/28 04:04
PHST- 2022/04/27 00:00 [received]
PHST- 2022/10/18 00:00 [revised]
PHST- 2022/10/29 00:00 [accepted]
PHST- 2022/11/28 04:04 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/11/18 00:00 [pmc-release]
AID - 10.1155/2022/4263417 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2022 Nov 18;2022:4263417. doi: 
      10.1155/2022/4263417. eCollection 2022.