PMID- 36438444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 2673-561X (Electronic)
IS  - 2673-561X (Print)
IS  - 2673-561X (Linking)
VI  - 3
DP  - 2022
TI  - TRPV1 in dorsal root ganglion contributed to bone cancer pain.
PG  - 1022022
LID - 10.3389/fpain.2022.1022022 [doi]
LID - 1022022
AB  - Tumor growth in situ or bone metastases in cancer patients all can induce bone 
      cancer pain. It is frequently occurred in patients with breast, prostate, and 
      lung cancer. Because of the lack of effective treatment, bone cancer pain causes 
      depression, anxiety, fatigue, and sleep disturbances in cancer patients, disrupts 
      the daily quality of life, and results in huge economic and psychological burden. 
      Over the past years, transient receptor potential channels (TRPs), especially TRP 
      vanilloid 1 (TRPV1) in dorsal root ganglion (DRG), have been considered to be 
      involved in bone cancer pain. The characteristic of TRPV1 had been well studied. 
      The mechanisms under TRPV1 regulation in DRG with bone cancer pain are complex, 
      including inflammatory mediators, endogenous formaldehyde, and other mechanisms. 
      In the present review, we summarize the role and potential mechanism of TRPV1 in 
      DRG in bone cancer pain. As the primary sensory neurons, targeting the TRPV1 
      channel in DRG, might have fewer side effects than in central. We hope 
      systematically understand of TRPV1 modulation in DRG will bring more effective 
      strategy.
CI  - (c) 2022 Chen, Li, Hao and Liu.
FAU - Chen, Wen
AU  - Chen W
AD  - International Acupuncture and Moxibustion Innovation Institute, Beijing 
      University of Chinese Medicine, Beijing, China.
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Li, Hongping
AU  - Li H
AD  - International Acupuncture and Moxibustion Innovation Institute, Beijing 
      University of Chinese Medicine, Beijing, China.
FAU - Hao, Xiaowan
AU  - Hao X
AD  - International Acupuncture and Moxibustion Innovation Institute, Beijing 
      University of Chinese Medicine, Beijing, China.
FAU - Liu, Cunzhi
AU  - Liu C
AD  - International Acupuncture and Moxibustion Innovation Institute, Beijing 
      University of Chinese Medicine, Beijing, China.
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221109
PL  - Switzerland
TA  - Front Pain Res (Lausanne)
JT  - Frontiers in pain research (Lausanne, Switzerland)
JID - 9918227269806676
PMC - PMC9682177
OTO - NOTNLM
OT  - TRPV1
OT  - bone cancer pain
OT  - dorsal root ganglion
OT  - mechanisms
OT  - regulation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/11/09
CRDT- 2022/11/28 04:17
PHST- 2022/08/18 00:00 [received]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/28 04:17 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - 10.3389/fpain.2022.1022022 [doi]
PST - epublish
SO  - Front Pain Res (Lausanne). 2022 Nov 9;3:1022022. doi: 10.3389/fpain.2022.1022022. 
      eCollection 2022.