PMID- 36438950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Inflammatory rheumatic diseases and the risk of Parkinson's disease: A systematic 
      review and meta-analysis.
PG  - 999820
LID - 10.3389/fneur.2022.999820 [doi]
LID - 999820
AB  - BACKGROUND: Several studies showed inconsistencies in the relationships between 
      inflammatory rheumatic diseases (IRDs) and the risk of Parkinson's disease (PD). 
      Therefore, we carried out a meta-analysis to investigate the associations between 
      different IRDs and PD risk. METHODS: A comprehensive search was undertaken on 
      PubMed, Embase, Cochrane Library, and Web of Science databases up to June 2022. 
      Studies reporting the relationships between IRDs and PD risk were included. 
      Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated 
      by using random-effects models. RESULTS: Twenty-two publications covering seven 
      IRDs containing data from 833,004 patients were identified for quantitative 
      analysis. The pooled results indicated that ankylosing spondylitis (RR = 1.55, 
      95% CI: 1.31-1.83, I(2) = 32.1%, P < 0.001), Sjogren's syndrome (RR = 1.34, 95% 
      CI: 1.22-1.47, I(2) = 58.5%, P < 0.001), and Behcet's disease (RR = 1.93, 95% CI: 
      1.07-3.49, I(2) = 57.6%, P = 0.030) were associated with an increased PD risk. 
      However, no significant associations were observed between gout, rheumatoid 
      arthritis, systemic lupus erythematosus, as well as polymyalgia rheumatica and 
      the subsequent development of PD. CONCLUSION: Ankylosing spondylitis, Sjogren's 
      syndrome, and Behcet's disease may increase PD risk.
CI  - Copyright (c) 2022 He, Zhao, Wang and Guo.
FAU - He, Lili
AU  - He L
AD  - Department of Neurology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Zhao, Hecong
AU  - Zhao H
AD  - Department of Neurology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Wang, Fuli
AU  - Wang F
AD  - Department of Neurology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Guo, Xiaoyan
AU  - Guo X
AD  - Department of Neurology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
LA  - eng
PT  - Systematic Review
DEP - 20221110
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9684169
OTO - NOTNLM
OT  - Parkinson's disease
OT  - inflammatory rheumatic diseases
OT  - meta-analysis
OT  - risk
OT  - systematic review
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/11/10
CRDT- 2022/11/28 04:27
PHST- 2022/07/21 00:00 [received]
PHST- 2022/10/24 00:00 [accepted]
PHST- 2022/11/28 04:27 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/11/10 00:00 [pmc-release]
AID - 10.3389/fneur.2022.999820 [doi]
PST - epublish
SO  - Front Neurol. 2022 Nov 10;13:999820. doi: 10.3389/fneur.2022.999820. eCollection 
      2022.