PMID- 36439228
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221206
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 12
DP  - 2022
TI  - Severe acute respiratory syndrome coronavirus 2 virus-like particles induce 
      dendritic cell maturation and modulate T cell immunity.
PG  - 986350
LID - 10.3389/fcimb.2022.986350 [doi]
LID - 986350
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that play an 
      important role in both innate and acquired immune responses against pathogens. 
      However, the role of DCs in coronavirus disease 2019 (COVID-19) is unclear. 
      Virus-like particles (VLPs) that structurally mimic the original virus are one of 
      the candidates COVID-19 vaccines. In the present study, severe acute respiratory 
      syndrome coronavirus 2 (SARS-CoV-2) VLPs were used as an alternative to live 
      virus to evaluate the interaction of the virus with DCs. The results revealed 
      that SARS-CoV-2 VLPs induced DC maturation by augmenting cell surface molecule 
      expression (CD80, CD86, and major histocompatibility complex class II (MHC-II)) 
      and inflammatory cytokine production (tumor necrosis factor-alpha, interleukin 
      (IL)-1beta, IL-6, and IL-12p70) in DCs via the mitogen-activated protein kinase and 
      nuclear factor-kappaB signaling pathways. In addition, mature DCs induced by 
      SARS-CoV-2 VLPs promoted T cell proliferation, which was dependent on VLPs 
      concentration. Our results suggest that SARS-CoV-2 VLPs regulate the immune 
      response by interacting with DCs. These findings will improve the understanding 
      of SARS-CoV-2 pathogenesis and SARS-CoV-2 vaccine development.
CI  - Copyright (c) 2022 Mi, Liang, Xu, Li, Wang, Dang, Deng, Zhi, Li and Tan.
FAU - Mi, Youjun
AU  - Mi Y
AD  - Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical 
      Translation and Lanzhou Center for Tuberculosis Research, School of Basic Medical 
      Sciences, Lanzhou University, Lanzhou, China.
AD  - Institute of pathophysiology, School of Basic Medical Sciences, Lanzhou 
      University, Lanzhou, China.
FAU - Liang, Lijuan
AU  - Liang L
AD  - The First Clinical Medical College, Gansu University of Chinese Medicine, 
      Lanzhou, China.
FAU - Xu, Kun
AU  - Xu K
AD  - Institute of Immunology, School of Basic Medicine Sciences, Lanzhou University, 
      Lanzhou, China.
FAU - Li, Qing
AU  - Li Q
AD  - Institute of pathophysiology, School of Basic Medical Sciences, Lanzhou 
      University, Lanzhou, China.
FAU - Wang, Wenting
AU  - Wang W
AD  - Institute of Immunology, School of Basic Medicine Sciences, Lanzhou University, 
      Lanzhou, China.
FAU - Dang, Wenrui
AU  - Dang W
AD  - Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical 
      Translation and Lanzhou Center for Tuberculosis Research, School of Basic Medical 
      Sciences, Lanzhou University, Lanzhou, China.
FAU - Deng, Jiahui
AU  - Deng J
AD  - Institute of pathophysiology, School of Basic Medical Sciences, Lanzhou 
      University, Lanzhou, China.
FAU - Zhi, Yucheng
AU  - Zhi Y
AD  - Institute of Combined Western and Chinese Traditional Medicine, School of Basic 
      Medicine Sciences, Lanzhou University, Lanzhou, China.
FAU - Li, Xuefeng
AU  - Li X
AD  - Institute of Combined Western and Chinese Traditional Medicine, School of Basic 
      Medicine Sciences, Lanzhou University, Lanzhou, China.
FAU - Tan, Jiying
AU  - Tan J
AD  - Institute of Immunology, School of Basic Medicine Sciences, Lanzhou University, 
      Lanzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221109
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - Humans
MH  - *SARS-CoV-2
MH  - T-Lymphocytes
MH  - COVID-19 Vaccines
MH  - *COVID-19
MH  - Dendritic Cells
PMC - PMC9682005
OTO - NOTNLM
OT  - COVID-19
OT  - SARS-CoV-2
OT  - T cell
OT  - dendritic cells
OT  - virus-like particles (VLPs)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/30 06:00
PMCR- 2022/11/09
CRDT- 2022/11/28 04:33
PHST- 2022/07/05 00:00 [received]
PHST- 2022/10/24 00:00 [accepted]
PHST- 2022/11/28 04:33 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - 10.3389/fcimb.2022.986350 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2022 Nov 9;12:986350. doi: 
      10.3389/fcimb.2022.986350. eCollection 2022.