PMID- 36439417
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 12
DP  - 2022
TI  - Case report: Atypical spindle cell/pleomorphic lipomatous tumor masquerading as a 
      myxoid liposarcoma or intramuscular myxoma.
PG  - 1033114
LID - 10.3389/fonc.2022.1033114 [doi]
LID - 1033114
AB  - Atypical spindle cell/pleomorphic lipomatous tumors (ASPLTs) were recently 
      categorized as benign lipomatous tumors. However, accurate and complete 
      preoperative diagnosis of ASPLTs may be difficult. Furthermore, diagnosis based 
      on magnetic resonance imaging (MRI) findings is uncertain because of the varying 
      ratios of the fat component within the tumor. Here, we report a case of ASPLT 
      masquerading as a myxoid tumor. Although MRI findings were consistent with a 
      myxoid liposarcoma, needle biopsy findings suggested a myxoma, and we performed 
      marginal resection. Histopathological findings revealed infiltrating spindle 
      cells with atypia. In addition, immunohistochemistry (IHC) showed positive 
      staining for CD34 and heterogeneous retinoblastoma deficiency, and fluorescence 
      in situ hybridization (FISH) showed no amplification of mouse double minute 2 
      homolog and no rearrangement of FUS or EWSR1. When MRI and histopathological 
      findings suggest a myxoid tumor, IHC and FISH should be considered and performed 
      for a precise and accurate diagnosis.
CI  - Copyright (c) 2022 Ichikawa, Kawasaki, Imada, Kanno, Taniguchi, Ashizawa and Haro.
FAU - Ichikawa, Jiro
AU  - Ichikawa J
AD  - Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, 
      University of Yamanashi, Chuo, Yamanashi, Japan.
FAU - Kawasaki, Tomonori
AU  - Kawasaki T
AD  - Department of Pathology, Saitama Medical University International Medical Center, 
      Hidaka, Saitama, Japan.
FAU - Imada, Hiroki
AU  - Imada H
AD  - Department of Pathology, Saitama Medical Center, Saitama Medical University, 
      Kawagoe, Saitama, Japan.
FAU - Kanno, Satoshi
AU  - Kanno S
AD  - Department of Pathology, Saitama Medical University International Medical Center, 
      Hidaka, Saitama, Japan.
FAU - Taniguchi, Naofumi
AU  - Taniguchi N
AD  - Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, 
      University of Yamanashi, Chuo, Yamanashi, Japan.
FAU - Ashizawa, Tomoyuki
AU  - Ashizawa T
AD  - Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, 
      University of Yamanashi, Chuo, Yamanashi, Japan.
FAU - Haro, Hirotaka
AU  - Haro H
AD  - Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, 
      University of Yamanashi, Chuo, Yamanashi, Japan.
LA  - eng
PT  - Case Reports
DEP - 20221110
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC9684626
OTO - NOTNLM
OT  - atypical spindle cell/pleomorphic lipomatous tumor
OT  - differential diagnosis
OT  - fluorescence in situ hybridization
OT  - histopathology
OT  - immunohistochemistry
OT  - magnetic resonance imaging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/01/01
CRDT- 2022/11/28 04:37
PHST- 2022/08/31 00:00 [received]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/28 04:37 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2022.1033114 [doi]
PST - epublish
SO  - Front Oncol. 2022 Nov 10;12:1033114. doi: 10.3389/fonc.2022.1033114. eCollection 
      2022.