PMID- 36439902
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 2219-2808 (Print)
IS  - 2219-2808 (Electronic)
IS  - 2219-2808 (Linking)
VI  - 11
IP  - 6
DP  - 2022 Nov 9
TI  - Cow's milk-induced gastrointestinal disorders: From infancy to adulthood.
PG  - 437-454
LID - 10.5409/wjcp.v11.i6.437 [doi]
AB  - Milk is related to many gastrointestinal disorders from the cradle to the grave 
      due to the many milk ingredients that can trigger gastrointestinal discomfort and 
      disorders. Cow's milk protein allergy (CMPA) is the most common food allergy, 
      especially in infancy and childhood, which may persist into adulthood. There are 
      three main types of CMPA; immunoglobulin E (IgE)-mediated CMPA, non-IgE-mediated 
      CMPA, and mixed type. CMPA appears before the first birthday in almost all cases. 
      Symptoms may start even during the neonatal period and can be severe enough to 
      simulate neonatal sepsis. CMPA (often non-IgE mediated) can present with symptoms 
      of gastroesophageal reflux, eosinophilic esophagitis, hemorrhagic gastritis, food 
      protein-induced protein-losing enteropathy, and food protein-induced 
      enterocolitis syndrome. Most CMPAs are benign and outgrown during childhood. CMPA 
      is not as common in adults as in children, but when present, it is usually severe 
      with a protracted course. Lactose intolerance is a prevalent condition 
      characterized by the development of many symptoms related to the consumption of 
      foods containing lactose. Lactose intolerance has four typical types: 
      Developmental, congenital, primary, and secondary. Lactose intolerance and CMPA 
      may be the underlying pathophysiologic mechanisms for many functional 
      gastrointestinal disorders in children and adults. They are also common in 
      inflammatory bowel diseases. Milk consumption may have preventive or promoter 
      effects on cancer development. Milk may also become a source of microbial 
      infection in humans, causing a wide array of diseases, and may help increase the 
      prevalence of antimicrobial resistance. This editorial summarizes the common 
      milk-related disorders and their symptoms from childhood to adulthood.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Al-Beltagi, Mohammed
AU  - Al-Beltagi M
AD  - Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 31511, 
      Algharbia, Egypt.
AD  - Department of Pediatrics, University Medical Center, Arabian Gulf University, 
      Manama 26671, Bahrain. mbelrem@hotmail.com.
FAU - Saeed, Nermin Kamal
AU  - Saeed NK
AD  - Department of Pathology, Microbiology Section, Salmaniya Medical Complex, Manama 
      26671, Bahrain.
AD  - Department of Pathology, Microbiology Section, Royal College of Surgeons in 
      Ireland - Bahrain, Busaiteen 15503, Muharraq, Bahrain.
FAU - Bediwy, Adel Salah
AU  - Bediwy AS
AD  - Department of Chest Diseases, Faculty of Medicine, Tanta University, Tanta 31527, 
      Algharbia, Egypt.
AD  - Department of Chest Diseases, University Medical Center, Arabian Gulf University, 
      Manama 26671, Bahrain.
FAU - Elbeltagi, Reem
AU  - Elbeltagi R
AD  - Department of Medicine, The Royal College of Surgeons in Ireland - Bahrain, 
      Busiateen 15503, Muharraq, Bahrain.
LA  - eng
PT  - Editorial
DEP - 20221109
PL  - United States
TA  - World J Clin Pediatr
JT  - World journal of clinical pediatrics
JID - 101627548
PMC - PMC9685681
OTO - NOTNLM
OT  - Adults
OT  - Children
OT  - Cow's milk
OT  - Cow's milk protein allergy
OT  - Functional gastrointestinal disorders
OT  - Lactose intolerance, Inflammatory bowel disease
OT  - Zoonosis
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/11/09
CRDT- 2022/11/28 04:46
PHST- 2022/08/14 00:00 [received]
PHST- 2022/09/01 00:00 [revised]
PHST- 2022/10/14 00:00 [accepted]
PHST- 2022/11/28 04:46 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - 10.5409/wjcp.v11.i6.437 [doi]
PST - epublish
SO  - World J Clin Pediatr. 2022 Nov 9;11(6):437-454. doi: 10.5409/wjcp.v11.i6.437. 
      eCollection 2022 Nov 9.