PMID- 36440180
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1179-1608 (Print)
IS  - 1179-1608 (Electronic)
IS  - 1179-1608 (Linking)
VI  - 14
DP  - 2022
TI  - Effects of CPAP Treatment on Electroencephalographic Activity in Patients with 
      Obstructive Sleep Apnea Syndrome During Deep Sleep with Consideration of Cyclic 
      Alternating Pattern.
PG  - 2075-2089
LID - 10.2147/NSS.S382305 [doi]
AB  - OBJECTIVE: To investigate whether continuous positive airway pressure (CPAP) 
      treatment would change EEG activities associated with cyclic alternating pattern 
      (CAP subtype A1, A2, and A3) and non-CAP (NCAP) during non-rapid eye movement 
      sleep stage 3 (N3) in patients with obstructive sleep apnea (OSA). METHODS: The 
      effects of CPAP treatment on the percentages of sleep stage N3 occupied by the 
      CAP and NCAP, power of EEG waves in the CAP and NCAP were examined in 18 patients 
      with moderate-to-severe OSA undergoing polysomnographic recordings. RESULTS: 
      Apnea and hypopnea index during sleep stage N3 was positively correlated with 
      ratios of phases A2 and A3 duration to total phase A duration [Phase (A2+A3) 
      /Phase A] and negatively correlated with phase A1/phase A. With CPAP treatment, 
      percentages of sleep stage N3 occupied by total CAPs and subtypes A2 and A3, as 
      well as CAP A2 and CAP A3 indexes were significantly decreased while percentages 
      of sleep stage N3 occupied by NCAP (NCAP/N3) and CAP A1 index were significantly 
      increased. In addition, CPAP treatment significantly decreased percentage of 
      respiratory events associated CAPs and increased percentage of non-respiratory 
      related CAPs. Moreover, absolute and relative delta power was significantly 
      increased during phase A1, unchanged during phase A2 and phase B2, and 
      significantly decreased during phases B1, A3 and B3. The absolute power of faster 
      frequency EEG waves in CAPs showed a general trend of decrease. The absolute and 
      relative power of delta waves with amplitudes >/=75 muV, but not <75 muV, was 
      significantly increased. CONCLUSION: CPAP treatment improves the sleep quality in 
      OSA patients mainly by increasing delta power and decreasing power of higher 
      frequency waves during phase A1, and decreasing CAP A2 and A3 indexes as well as 
      increasing NCAP/N3 and power of delta waves with amplitudes >/=75 muV during NCAP.
CI  - (c) 2022 Chen et al.
FAU - Chen, Shuliang
AU  - Chen S
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
AD  - Queen Mary College, Nanchang University, Jiangxi, People's Republic of China.
FAU - Li, Qi
AU  - Li Q
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
FAU - Zou, Xueliang
AU  - Zou X
AD  - Jiangxi Mental Hospital, Nanchang University, Jiangxi, People's Republic of 
      China.
FAU - Zhong, Zhijun
AU  - Zhong Z
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
FAU - Ouyang, Qian
AU  - Ouyang Q
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
FAU - Wang, Mengmeng
AU  - Wang M
AUID- ORCID: 0000-0001-9417-9598
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
FAU - Luo, Yaxing
AU  - Luo Y
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
FAU - Yao, Dongyuan
AU  - Yao D
AD  - Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi 
      Provincial People's Hospital and The First Affiliated Hospital of Nanchang 
      Medical College, Jiangxi, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20221121
PL  - New Zealand
TA  - Nat Sci Sleep
JT  - Nature and science of sleep
JID - 101537767
PMC - PMC9697441
OTO - NOTNLM
OT  - continuous positive airway pressure
OT  - cyclic alternating pattern
OT  - non-rapid eye movement sleep
OT  - obstructive sleep apnea
OT  - polysomnographic recordings
COIS- The authors declare no conflicts of interest in relation to this study.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/11/21
CRDT- 2022/11/28 04:50
PHST- 2022/07/13 00:00 [received]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/11/28 04:50 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/11/21 00:00 [pmc-release]
AID - 382305 [pii]
AID - 10.2147/NSS.S382305 [doi]
PST - epublish
SO  - Nat Sci Sleep. 2022 Nov 21;14:2075-2089. doi: 10.2147/NSS.S382305. eCollection 
      2022.