PMID- 36440184
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221129
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2022
DP  - 2022
TI  - Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique 
      to Treat Knee Osteoarthritis: A Retrospective Cohort Study.
PG  - 5394441
LID - 10.1155/2022/5394441 [doi]
LID - 5394441
AB  - BACKGROUND: Intra-articular bone marrow concentrate (BMC) and aspirate (BMA) 
      injections have been used with mixed results to treat osteoarthritis (OA). Given 
      the various aspiration and concentration methods available for preparing bone 
      marrow, more data are needed to identify the optimal bone marrow harvesting 
      techniques to treat OA. METHODS: This retrospective cohort study examined the 
      effect of using low-volume BMAs harvested using the Marrow Cellution (MC) device 
      on 160 patients (262 knees) suffering from pain due to knee OA, KL grades 2-4, 
      that did not respond to conservative treatment. Changes in visual analog scores 
      (VAS) for overall daily activity were examined over a six-month time frame in 
      these patients (63.5 +/- 0.97 years of age; 48.1% male). In addition, changes in 
      the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Patient 
      Global Impression of Change (PGIC scores) were examined over the same time frame 
      in a smaller subset of patients (95 patients including 172 knees). RESULTS: There 
      was a statistically significant improvement in VAS scores for overall daily 
      activity 6 months postprocedure in the study population, 7.29 +/- 0.27 vs. 3.76 +/- 
      0.34 (p < 0.0001), as well as statistically significant improvements in WOMAC 
      scores, 49.3 +/- 4.27 vs. 66.3 +/- 4.08 (p < 0.0001). On the individual level, 71% of 
      the cases displayed VAS improvements and 61% of the cases displayed WOMAC 
      improvements that exceeded levels previous studies determined to be the minimal 
      clinically important difference (MCID) for knee OA treatments. The improvements 
      in WOMAC scores were also seen in both the WOMAC pain subscore, 52.2 +/- 4.39 vs. 
      72.2 +/- 4.36 (p < 0.0001) and the WOMAC function subscore, 51.6 +/- 4.67 vs. 69.0 +/- 
      4.36 (p < 0.0001). In addition, the PGIC scores measuring patient satisfaction 
      improved from 4.03 +/- 0.26 at 6 weeks postprocedure to 4.65 +/- 0.28 at 6 months 
      postprocedure (p < 0.0001). CONCLUSIONS: Knee OA patients treated with MC BMA 
      intra-articular injections exhibited significant reductions in VAS pain scores 
      and significant improvements in WOMAC scores that exceeded the minimal clinically 
      important difference thresholds. In addition, reductions in VAS pain scores and 
      improvements in WOMAC scores correlated with higher PGIC scores.
CI  - Copyright (c) 2022 Daniel Kuebler et al.
FAU - Kuebler, Daniel
AU  - Kuebler D
AUID- ORCID: 0000-0001-8641-8149
AD  - Department of Biology, Franciscan University of Steubenville, Steubenville, OH 
      43952, USA.
FAU - Schnee, Alexandra
AU  - Schnee A
AD  - Atlas Medical Center, Irving TX 75062, USA.
FAU - Moore, Lisa
AU  - Moore L
AD  - Atlas Medical Center, Irving TX 75062, USA.
FAU - Kouri, Jason
AU  - Kouri J
AD  - Atlas Medical Center, Irving TX 75062, USA.
FAU - McLaughlin, Alexis
AU  - McLaughlin A
AD  - Atlas Medical Center, Irving TX 75062, USA.
FAU - Hanson, Robert
AU  - Hanson R
AD  - Atlas Medical Center, Irving TX 75062, USA.
FAU - Kuebler, Patrick
AU  - Kuebler P
AD  - Department of Biology, Franciscan University of Steubenville, Steubenville, OH 
      43952, USA.
FAU - Dallo, Ignacio
AU  - Dallo I
AD  - O.A.S.I. Bioresearch Foundation, Gobbi NPO, Milan, Italy.
FAU - Gobbi, Alberto
AU  - Gobbi A
AD  - O.A.S.I. Bioresearch Foundation, Gobbi NPO, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20221115
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC9682226
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/11/29 06:00
MHDA- 2022/11/29 06:01
PMCR- 2022/11/15
CRDT- 2022/11/28 04:50
PHST- 2022/02/04 00:00 [received]
PHST- 2022/10/19 00:00 [revised]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2022/11/28 04:50 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/11/29 06:01 [medline]
PHST- 2022/11/15 00:00 [pmc-release]
AID - 10.1155/2022/5394441 [doi]
PST - epublish
SO  - Stem Cells Int. 2022 Nov 15;2022:5394441. doi: 10.1155/2022/5394441. eCollection 
      2022.