PMID- 36441058 OWN - NLM STAT- MEDLINE DCOM- 20230602 LR - 20230602 IS - 1534-4436 (Electronic) IS - 1081-1206 (Linking) VI - 130 IP - 2 DP - 2023 Feb TI - Early, continuing exposure to cow's milk formula and cow's milk allergy: The COMEET study, a single center, prospective interventional study. PG - 233-239.e4 LID - S1081-1206(22)01852-X [pii] LID - 10.1016/j.anai.2022.10.013 [doi] AB - BACKGROUND: Cow's milk allergy (CMA) is a common food allergy among infants. Information regarding the best timing for first exposure to cow's milk formula (CMF) is controversial and more evidence is required. Few randomized control trials have tried to accurately assess the timing and preventive effect of exposure to CMF on small cohorts. OBJECTIVE: This study assessed the association between early, continuing exposure to CMF on the basis of the parents' preferences and the development of immunoglobulin E (IgE)-mediated CMA in a large birth cohort. METHODS: Newborns were prospectively recruited shortly before birth and divided into 2 groups according to parental feeding preference for the first 2 months of life: (1) exclusive breastfeeding (EBF); or (2) at least 1 meal of CMF (with or without breastfeeding) daily. Infants were followed up monthly until the age of 12 months. RESULTS: Among 1992 infants participating in the study, 1073 (53.86%) were in the EBF group until 2 months of age. IgE-mediated CMA was confirmed in 0.85% (n = 17); all were in the EBF group. Within this group, the prevalence of IgE-mediated CMA was 1.58% compared with 0 in the other groups (relative risk, 29.98; P < .001). Post hoc analysis revealed IgE-mediated CMA prevalence of 0.7% in the per-protocol EBF group vs 3.27% among breastfed infants who were exposed to a small amount of CMF during the first 2 months of life. A family atopic background did not affect the results. CONCLUSION: Early, continuing exposure to CMF from birth has the potential to prevent the development of IgE-mediated CMA and should be encouraged. However, the exposure needs to be consistent because occasional exposure increases the risk of developing IgE-mediated CMA and should be avoided. CI - Copyright (c) 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. FAU - Lachover-Roth, Idit AU - Lachover-Roth I AD - Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: Idit.roth@clalit.org.il. FAU - Cohen-Engler, Anat AU - Cohen-Engler A AD - Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel. FAU - Furman, Yael AU - Furman Y AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel. FAU - Shachar, Ido AU - Shachar I AD - Department of Statistics and Data Science, Faculty of Social Sciences, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Rosman, Yossi AU - Rosman Y AD - Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Meir-Shafrir, Keren AU - Meir-Shafrir K AD - Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel. FAU - Mozer-Mandel, Michal AU - Mozer-Mandel M AD - Department of Statistics and Data Science, Faculty of Social Sciences, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Farladansky-Gershnabel, Sivan AU - Farladansky-Gershnabel S AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel. FAU - Biron-Shental, Tal AU - Biron-Shental T AD - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel. FAU - Mandel, Micha AU - Mandel M AD - Department of Statistics and Data Science, Faculty of Social Sciences, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Confino-Cohen, Ronit AU - Confino-Cohen R AD - Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221028 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 RN - 37341-29-0 (Immunoglobulin E) SB - IM CIN - Ann Allergy Asthma Immunol. 2023 Feb;130(2):151-152. PMID: 36737157 MH - Animals MH - Cattle MH - Female MH - *Food Hypersensitivity/prevention & control MH - Immunoglobulin E MH - Milk MH - *Milk Hypersensitivity/epidemiology/prevention & control MH - Prospective Studies MH - Humans MH - Infant, Newborn MH - *Infant Formula MH - Infant EDAT- 2022/11/29 06:00 MHDA- 2023/02/08 06:00 CRDT- 2022/11/28 10:22 PHST- 2022/08/22 00:00 [received] PHST- 2022/10/14 00:00 [revised] PHST- 2022/10/18 00:00 [accepted] PHST- 2022/11/29 06:00 [pubmed] PHST- 2023/02/08 06:00 [medline] PHST- 2022/11/28 10:22 [entrez] AID - S1081-1206(22)01852-X [pii] AID - 10.1016/j.anai.2022.10.013 [doi] PST - ppublish SO - Ann Allergy Asthma Immunol. 2023 Feb;130(2):233-239.e4. doi: 10.1016/j.anai.2022.10.013. Epub 2022 Oct 28.