PMID- 36442291
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230218
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 148
DP  - 2023 Feb
TI  - Prediction of cord blood leptin on infant's neurodevelopment: A birth cohort in 
      rural Yunnan, China.
PG  - 105955
LID - S0306-4530(22)00296-7 [pii]
LID - 10.1016/j.psyneuen.2022.105955 [doi]
AB  - BACKGROUND: Leptin, one of the peptide hormones secreted by adipocytes, plays a 
      vital part in metabolism, but its role in early-life neurodevelopment remains 
      poorly understood. METHODS: We performed leptin analysis on 323 cord blood 
      samples collected from a birth cohort in Yunnan rural area, China, and assessed 
      infants' neurodevelopment at one year of age by the Bayley Scales of Infant and 
      Toddler Development-Third Edition (BSID-III). Multiple linear regression and 
      binary logistic regression models were used to explore the associations between 
      cord blood leptin (CBL) concentrations and infants' neurodevelopment and the 
      ability of CBL to predict the probabilities of infants' neurodevelopment delay. 
      RESULTS: Overall, 323 infants were included in this study. The median 
      concentration of CBL was 4.7 ng/ml. The proportion of 1-year-old infants 
      identified as being neurodevelopmental delayed was 34.5%, and delays in 
      cognitive, language, and motor domains were 11.1%, 26.6%, and 13.9%, 
      respectively. Multiple linear regression analyses manifested that the CBL 
      concentration (log10-transformed) was positively correlated with the cognitive, 
      language, and motor composite scores in infants, respectively (beta = 7.76, 95%CI: 
      3.81-11.71; beta = 6.73, 95%CI: 3.41-10.06; and beta = 6.88, 95%CI: 3.48-10.29, 
      respectively). Binary logistic regression analysis showed that compared with the 
      higher, lower CBL (< 4.7 ng/ml) yielded a 1.41-fold increase in the risk of 
      language development delay (OR = 2.41，95%CI: 1.42-4.09), a 1.49-fold higher risk 
      of motor development delay (OR = 2.49, 95%CI: 1.25-4.96), and a 1.71-fold higher 
      risk of neurodevelopment delay (OR = 2.71, 95%CI: 1.64-4.48) among infants. The 
      prediction models showed that the probabilities of development delay in infants' 
      language, motor, and neurodevelopment increased with the decline of CBL 
      concentrations [r(s) = -0.63 (95% CI: -0.71, -0.56), r(s) = -0.46 (95% CI: -0.55, 
      -0.38), r(s) = -0.55 (95% CI: -0.63, -0.46), respectively]. CONCLUSION: The 
      decline of CBL was associated with the decrease in infants' neurodevelopment 
      scores at one year of age. CBL below 4.7 ng/ml may increase the risk of infants' 
      neurodevelopment delay. The probabilities of infants' neurodevelopment delay 
      increased with the decrease of CBL concentrations. CBL may be a predictor of the 
      probability of children's neurodevelopment delay.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Chen, Shuqi
AU  - Chen S
AD  - School of Public Health, Kunming Medical University, Kunming, China; Ministry of 
      Child Health, Longgang District Maternity & Child Healthcare Hospital of 
      Shenzhen, Shenzhen, Guangdong, China.
FAU - Xiao, Xia
AU  - Xiao X
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Song, Xiaoxiao
AU  - Song X
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Qi, Zhiye
AU  - Qi Z
AD  - School of Public Health, Kunming Medical University, Kunming, China; Department 
      of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, 
      Yunnan, China.
FAU - Li, Yan
AU  - Li Y
AD  - School of Public Health, Kunming Medical University, Kunming, China. Electronic 
      address: yanli20021965@21cn.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221019
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Leptin)
SB  - IM
MH  - Humans
MH  - Infant
MH  - *Birth Cohort
MH  - *Leptin
MH  - Fetal Blood
MH  - Child Development
MH  - China
OTO - NOTNLM
OT  - Cord blood leptin
OT  - Infant
OT  - Neurodevelopment delay
COIS- Conflict of interest The authors have no conflict of interest to declare.
EDAT- 2022/11/29 06:00
MHDA- 2023/02/07 06:00
CRDT- 2022/11/28 18:15
PHST- 2022/06/17 00:00 [received]
PHST- 2022/09/17 00:00 [revised]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2022/11/28 18:15 [entrez]
AID - S0306-4530(22)00296-7 [pii]
AID - 10.1016/j.psyneuen.2022.105955 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2023 Feb;148:105955. doi: 
      10.1016/j.psyneuen.2022.105955. Epub 2022 Oct 19.