PMID- 36443039 OWN - NLM STAT- MEDLINE DCOM- 20221130 LR - 20230829 IS - 1672-173X (Print) IS - 1672-173X (Linking) VI - 53 IP - 6 DP - 2022 Nov TI - [Single-Center Experience of Treating Chronic Limb-Threatening Ischemia of Lower Limbs Combined with Diabetes]. PG - 988-992 LID - 10.12182/20221160506 [doi] AB - OBJECTIVE: To summarize our hospital's single-center experience of and reflections on the treatment of chronic limb-threatening ischemia (CLTI) of lower limbs combined with diabetes in the past 5 years. METHODS: We retrospectively analyzed cases of lower limb CLTI combined with diabetes diagnosed at our hospital from March 2017 to June 2021. The baseline data, surgical information, and follow-up results of the patients were collected. The primary outcome indicator was the patency rate of lower limb target artery within 1 year post-op, and the secondary indicators were the reoperation rate within 1 year post-op and the amputation rate within 1 year post-op. RESULTS: A total of 89 patients with lower limb CLTI combined with diabetes were included in the study. A total of 85 patients underwent percutaneous transluminal angioplasty and the operation of 7 patients ended in failure, with the operation success rate reaching 91.76% (78/85). Three patients underwent femoral popliteal artery bypass grafting with artificial blood vessels and one patient underwent iliac femoral artery bypass grafting with artificial blood vessels, with the success rate of the operations reachign 100% (4/4). Among 78 patients who successfully underwent percutaneous transluminal angioplasty, the median follow-up time was 33 months (13, 64). Two patients died within one year after operation, with the post-op one-year survival rate being 97.44% (76/78). The post-op 1-year reoperation rate was 19.23% (15/78), the 1-year target vascular patency rate (deaths not included) was 85.53% (65/76), and the 1-year amputation rate was 3.85% (3/78). Among the patients who underwent bypass surgery, the follow-up period was 13-48 months. No thrombosis in or re-occlusion of the artificial blood vessels were observed during the follow-up period, and the artificial blood vessels remained unoccluded. CONCLUSION: Transluminal angioplasty has a relatively ideal rate of postoperative vascular patency. In addition, it is a minimally invasive procedure involving low perioperative risks and is performed under local anesthesia. Therefore, it can be used as the preferred treatment for patients with CLTI. On the other hand, bypass surgery has good long-term patency rate, but it involves higher perioperative risks and the procedure is more invasive. Therefore, bypass surgery can be used as an alternative when transluminal angioplasty ends in failure. CI - Copyright(c) by Editorial Board of Journal of Sichuan University (Medical Sciences). FAU - Luo, Xin AU - Luo X AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Huang, Ke AU - Huang K AD - West China School of Clinical Medicine, Sichuan University, Chengdu 610041, China. FAU - Huang, Bin AU - Huang B AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Wen, Xin AU - Wen X AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Li, Yi-Yuan AU - Li YY AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Zhao, Ji-Chun AU - Zhao JC AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Ran, Xing-Wu AU - Ran XW AD - Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, , West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Chen, Da-Wei AU - Chen DW AD - Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, , West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Gao, Yun AU - Gao Y AD - Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, , West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Chen, Xi-Yang AU - Chen XY AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Du, Xiao-Jiong AU - Du XJ AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Guo, Qiang AU - Guo Q AD - Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. LA - chi PT - English Abstract PT - Journal Article PL - China TA - Sichuan Da Xue Xue Bao Yi Xue Ban JT - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition JID - 101162609 RN - 0 (Blood Substitutes) SB - IM MH - Humans MH - Chronic Limb-Threatening Ischemia MH - *Blood Substitutes MH - Retrospective Studies MH - Lower Extremity MH - *Diabetes Mellitus PMC - PMC10408967 OTO - NOTNLM OT - Bypass surgery OT - Chronic limb-threatening ischemia OT - Diabetes mellitus OT - Percutaneous transluminal angioplasty COIS- 利益冲突　所有作者均声明不存在利益冲突 EDAT- 2022/11/29 06:00 MHDA- 2022/12/01 06:00 PMCR- 2022/11/20 CRDT- 2022/11/28 21:43 PHST- 2022/11/28 21:43 [entrez] PHST- 2022/11/29 06:00 [pubmed] PHST- 2022/12/01 06:00 [medline] PHST- 2022/11/20 00:00 [pmc-release] AID - scdxxbyxb-53-6-988 [pii] AID - 10.12182/20221160506 [doi] PST - ppublish SO - Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Nov;53(6):988-992. doi: 10.12182/20221160506.