PMID- 36443388
OWN - NLM
STAT- MEDLINE
DCOM- 20221130
LR  - 20230113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Nov 28
TI  - Use of different endpoints to determine the bioavailability of polychlorinated 
      dibenzo-p-dioxins/furans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in 
      Sprague-Dawley rats.
PG  - 20433
LID - 10.1038/s41598-022-25042-3 [doi]
LID - 20433
AB  - Liver, fat (adipose tissue), blood, and feces are common endpoints used to 
      determine the bioavailability of persistent organic pollutants (POPs). However, 
      it is not known whether the bioavailability of each endpoints is comparable or 
      whether there is a comprehensive endpoint that can be used for all congeners for 
      the measurement of bioavailability. In this study, we observed the accumulation 
      and distribution of 10 polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and 18 
      polychlorinated biphenyls (PCBs) in different organs of Sprague-Dawley (SD) rats 
      and calculated the bioavailability based on feces, liver, and fat endpoints. Our 
      results indicated that PCB 126, PCB 169, and 50% of PCDD/F congeners were mainly 
      accumulated in the liver, with a bioavailability ranging from 28.9 to 50.6%. On 
      the other hand, higher chlorinated (> 5 Cl) PCB congeners were mainly accumulated 
      in adipose tissues, with a bioavailability ranging from 20.1 to 82.2%, while 
      lower chlorinated (< 5 Cl) pollutants, such as 2,3,7,8-TeCDF, 2,3,7,8-TeCDD, 
      1,2,3,7,8-PeCDF, and PCB 28, 52, 77, 81, were likely metabolized over 36% in rats 
      during the 8-week experimental period. If we considered metabolization 
      (degradation) as a type of bioavailable process, then the fecal endpoint was a 
      feasible option. However, if we considered the selective accumulation behavior of 
      some congeners in different organs/tissues, then there was no single 
      comprehensive endpoint suitable for all congeners. Lastly, female rats showed 
      significantly higher PCDD bioavailability than male rats at low dose level 
      (0.2 ng/100 g b.w./d); however, the difference in PCB bioavailability between 
      female and male rats was not significant.
CI  - (c) 2022. The Author(s).
FAU - Shen, Haitao
AU  - Shen H
AD  - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng 
      Road, Hangzhou, 310051, China.
FAU - Han, Jianlong
AU  - Han J
AD  - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng 
      Road, Hangzhou, 310051, China.
FAU - Guan, Rongfa
AU  - Guan R
AD  - College of Food Science and Technology, Zhejiang University of Technology, 
      Hangzhou, 310014, China.
FAU - Cai, Delei
AU  - Cai D
AD  - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng 
      Road, Hangzhou, 310051, China.
FAU - Zheng, Yibin
AU  - Zheng Y
AD  - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng 
      Road, Hangzhou, 310051, China.
FAU - Meng, Zhen
AU  - Meng Z
AD  - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng 
      Road, Hangzhou, 310051, China.
FAU - Chen, Qing
AU  - Chen Q
AD  - Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng 
      Road, Hangzhou, 310051, China.
FAU - Li, Jingguang
AU  - Li J
AD  - NHC Key Laboratory Food Safety Risk Assessment, Chinese Academy of Medical 
      Sciences Research Unit (2019RU014 Food Safety), China National Center for Food 
      Safety Risk Assessment, Building 2, Guangqu Road 37, Beijing, 100022, China.
FAU - Wu, Yongning
AU  - Wu Y
AD  - NHC Key Laboratory Food Safety Risk Assessment, Chinese Academy of Medical 
      Sciences Research Unit (2019RU014 Food Safety), China National Center for Food 
      Safety Risk Assessment, Building 2, Guangqu Road 37, Beijing, 100022, China. 
      wuyongning@cfsa.net.cn.
LA  - eng
GR  - LGC20B050004/Science Technology Department of Zhejiang Province/
GR  - 2017YFC1600500/National Key R&amp;D Program of China/
GR  - 81472986/National Natural Science Fund of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221128
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Dibenzofurans)
RN  - 0 (Furans)
SB  - IM
MH  - Female
MH  - Male
MH  - Rats
MH  - Animals
MH  - *Polychlorinated Dibenzodioxins
MH  - *Polychlorinated Biphenyls
MH  - Rats, Sprague-Dawley
MH  - Dibenzofurans
MH  - Furans
MH  - Biological Availability
PMC - PMC9705297
COIS- The authors declare no competing interests.
EDAT- 2022/11/29 06:00
MHDA- 2022/12/01 06:00
PMCR- 2022/11/28
CRDT- 2022/11/28 23:32
PHST- 2022/09/10 00:00 [received]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/11/28 23:32 [entrez]
PHST- 2022/11/29 06:00 [pubmed]
PHST- 2022/12/01 06:00 [medline]
PHST- 2022/11/28 00:00 [pmc-release]
AID - 10.1038/s41598-022-25042-3 [pii]
AID - 25042 [pii]
AID - 10.1038/s41598-022-25042-3 [doi]
PST - epublish
SO  - Sci Rep. 2022 Nov 28;12(1):20433. doi: 10.1038/s41598-022-25042-3.