PMID- 36444031
OWN - NLM
STAT- MEDLINE
DCOM- 20221130
LR  - 20221130
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 404
IP  - Pt A
DP  - 2023 Mar 15
TI  - Proanthocyanidins in grape seeds and their role in gut microbiota-white adipose 
      tissue axis.
PG  - 134405
LID - S0308-8146(22)02367-6 [pii]
LID - 10.1016/j.foodchem.2022.134405 [doi]
AB  - Several factors can impact the gut microbiota, affecting host metabolism and 
      immunity. It implies intestinal barrier disruption and translocation of gut 
      microbiota metabolites to the bloodstream, such as lipopolysaccharides (LPS). LPS 
      is an endotoxin from gram-negative gut bacteria that trigger the activation of 
      the Toll-like receptor-4 (TLR-4) inflammatory pathway and can modulate white 
      adipose tissue (WAT) metabolism. Dietary components, including diets rich in 
      fiber and polyphenols, contribute to intestinal environment homeostasis. Grape 
      seed proanthocyanidins extract (GSPE) may improve intestinal permeability and 
      microbial diversity and increase short-chain fatty acids production. Furthermore, 
      GSPE has been involved in LPS reduction, down-regulating the TLR-4 pathway, 
      decreasing the WAT metainflammatory profile, and preventing adipocyte 
      hypertrophy. Studies have pointed out strategies to promote health and control 
      obesity by modulating the gut microbiota environment. Therefore, this review aims 
      to summarize the potential effects of GSPE on the gut microbiota-white adipose 
      tissue axis against obesity.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Ferreira, Yasmin Alaby Martins
AU  - Ferreira YAM
AD  - Post Graduate Program of Nutrition - Paulista Medicine School, Federal University 
      of Sao Paulo (UNIFESP), Sao Paulo/SP, Brazil.
FAU - Jamar, Giovana
AU  - Jamar G
AD  - Post Graduate Program of Nutrition - Paulista Medicine School, Federal University 
      of Sao Paulo (UNIFESP), Sao Paulo/SP, Brazil.
FAU - Estadella, Debora
AU  - Estadella D
AD  - Department of Biosciences, Institute of Health and Science, Federal University of 
      Sao Paulo (UNIFESP), Campus Baixada Santista, Santos/SP, Brazil. Electronic 
      address: estadella@unifesp.br.
FAU - Pisani, Luciana Pellegrini
AU  - Pisani LP
AD  - Department of Biosciences, Institute of Health and Science, Federal University of 
      Sao Paulo (UNIFESP), Campus Baixada Santista, Santos/SP, Brazil. Electronic 
      address: pisani@unifesp.br.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220926
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Proanthocyanidins)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Dietary Fiber)
SB  - IM
MH  - *Proanthocyanidins
MH  - *Gastrointestinal Microbiome
MH  - Toll-Like Receptor 4
MH  - *Vitis
MH  - Lipopolysaccharides
MH  - Health Promotion
MH  - Adipose Tissue, White
MH  - Dietary Fiber
MH  - Obesity
OTO - NOTNLM
OT  - Gut microbiota
OT  - Inflammation
OT  - Obesity
OT  - Proanthocyanidins
OT  - TLR4 pathway
OT  - White adipose tissue
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/30 06:00
MHDA- 2022/12/01 06:00
CRDT- 2022/11/29 01:09
PHST- 2022/03/18 00:00 [received]
PHST- 2022/08/25 00:00 [revised]
PHST- 2022/09/22 00:00 [accepted]
PHST- 2022/11/29 01:09 [entrez]
PHST- 2022/11/30 06:00 [pubmed]
PHST- 2022/12/01 06:00 [medline]
AID - S0308-8146(22)02367-6 [pii]
AID - 10.1016/j.foodchem.2022.134405 [doi]
PST - ppublish
SO  - Food Chem. 2023 Mar 15;404(Pt A):134405. doi: 10.1016/j.foodchem.2022.134405. 
      Epub 2022 Sep 26.