PMID- 36444143
OWN - NLM
STAT- MEDLINE
DCOM- 20230104
LR  - 20230303
IS  - 1759-7714 (Electronic)
IS  - 1759-7706 (Print)
IS  - 1759-7706 (Linking)
VI  - 14
IP  - 1
DP  - 2023 Jan
TI  - Chinese expert consensus on the diagnosis and treatment of HER2-altered non-small 
      cell lung cancer.
PG  - 91-104
LID - 10.1111/1759-7714.14743 [doi]
AB  - Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase 
      activity and participates in cell growth, differentiation and migration, and 
      survival. Its alterations, mainly including mutations, amplifications, and 
      overexpression are associated with poor prognosis and are one of the major 
      drivers in non-small cell lung cancer (NSCLC). Several clinical trials had been 
      investigating on the treatments of HER2-altered NSCLC, including conventional 
      chemotherapy, programmed death 1 (PD-1) inhibitors, tyrosine kinase inhibitors 
      (TKIs) and antibody-drug conjugates (ADCs), however, the results were either 
      disappointing or encouraging, but inconsistent. Trastuzumab deruxtecan (T-DXd) 
      was recently approved by the Food and Drug Administration as the first targeted 
      agent for treating HER2-mutant NSCLC. Effective screening of patients is the key 
      to the clinical application of HER2-targeted agents such as TKIs and ADCs. 
      Various testing methods are nowadays available, including polymerase chain 
      reaction (PCR), next-generation sequencing (NGS), fluorescence in situ 
      hybridization (FISH), immunohistochemistry (IHC), etc. Each method has its pros 
      and cons and should be reasonably assigned to appropriate patients for diagnosis 
      and guiding treatment decisions. To help standardize the clinical workflow, our 
      expert group reached a consensus on the clinical management of HER2-altered 
      NSCLC, focusing on the diagnosis and treatment strategies.
CI  - (c) 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and 
      John Wiley & Sons Australia, Ltd.
FAU - Zhang, Shirong
AU  - Zhang S
AUID- ORCID: 0000-0001-9334-1637
AD  - Translational Medicine Research Center, Key Laboratory of Clinical Cancer 
      Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou 
      First People's Hospital, Cancer Center, Zhejiang University School of Medicine, 
      Hangzhou, China.
FAU - Wang, Wenxian
AU  - Wang W
AUID- ORCID: 0000-0002-3047-4149
AD  - Department of Chemotherapy, Chinese Academy of Sciences University Cancer 
      Hospital (Zhejiang Cancer Hospital), Hangzhou, China.
FAU - Xu, Chunwei
AU  - Xu C
AUID- ORCID: 0000-0002-9021-6731
AD  - Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, 
      Hangzhou, China.
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Zhang, Yongchang
AU  - Zhang Y
AUID- ORCID: 0000-0002-6829-7176
AD  - Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan 
      Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, 
      Central South University, Changsha, China.
FAU - Cai, Xiuyu
AU  - Cai X
AD  - Department of VIP Inpatient, Sun Yet-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer 
      Medicine, Guangzhou, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of 
      Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
FAU - Song, Zhengbo
AU  - Song Z
AUID- ORCID: 0000-0002-4817-7775
AD  - Department of Chemotherapy, Chinese Academy of Sciences University Cancer 
      Hospital (Zhejiang Cancer Hospital), Hangzhou, China.
FAU - Li, Ziming
AU  - Li Z
AD  - Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Yu, Jinpu
AU  - Yu J
AD  - Department of Cancer Molecular Diagnostics Core, Tianjin Medical University 
      Cancer Institute and Hospital, Tianjin, China.
FAU - Zhong, Wenzhao
AU  - Zhong W
AUID- ORCID: 0000-0002-8917-8635
AD  - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational 
      Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, School of Medicine, Guangzhou, China.
FAU - Wang, Zhijie
AU  - Wang Z
AD  - State Key Laboratory of Molecular Oncology, Department of Medical Oncology, 
      National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Liu, Jingjing
AU  - Liu J
AD  - Department of Thoracic Cancer, Jilin Cancer Hospital, Changchun, China.
FAU - Liu, Anwen
AU  - Liu A
AD  - Department of Oncology, Second Affiliated Hospital of Nanchang University, 
      Nanchang, China.
FAU - Li, Wen
AU  - Li W
AD  - Key Laboratory of Respiratory Disease of Zhejiang Province, Department of 
      Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang 
      University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, 
      China.
FAU - Zhan, Ping
AU  - Zhan P
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Liu, Hongbing
AU  - Liu H
AUID- ORCID: 0000-0003-1404-0647
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Lv, Tangfeng
AU  - Lv T
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Miao, Liyun
AU  - Miao L
AUID- ORCID: 0000-0001-9586-3244
AD  - Department of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical 
      School of Nanjing University, Nanjing, China.
FAU - Min, Lingfeng
AU  - Min L
AD  - Department of Respiratory Medicine, Clinical Medical School of Yangzhou 
      University, Subei People's Hospital of Jiangsu Province, Yangzhou, China.
FAU - Lin, Gen
AU  - Lin G
AUID- ORCID: 0000-0001-9411-5519
AD  - Department of Medical Oncology, Fujian Medical University Cancer Hospital and 
      Fujian Cancer Hospital, Fuzhou, China.
FAU - Huang, Long
AU  - Huang L
AUID- ORCID: 0000-0003-4925-5162
AD  - Department of Oncology, Second Affiliated Hospital of Nanchang University, 
      Nanchang, China.
FAU - Yuan, Jingping
AU  - Yuan J
AD  - Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Jiang, Zhansheng
AU  - Jiang Z
AUID- ORCID: 0000-0002-5707-5148
AD  - Department of Integrative Oncology, Tianjin Medical University Cancer Institute 
      and Hospital, Tianjin, China.
FAU - Pu, Xingxiang
AU  - Pu X
AD  - Department of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The 
      Affiliated Cancer Hospital of Xiangya School of Medicine, Central South 
      University, Changsha, China.
FAU - Rao, Chuangzhou
AU  - Rao C
AD  - Department of Radiotherapy and Chemotherapy, Hwamei Hospital, University of 
      Chinese Academy of Sciences, Ningbo, China.
FAU - Lv, Dongqing
AU  - Lv D
AD  - Department of Pulmonary Medicine, Taizhou Hospital of Wenzhou Medical University, 
      Taizhou, China.
FAU - Yu, Zongyang
AU  - Yu Z
AD  - Department of Respiratory Medicine, the 900th Hospital of the Joint Logistics 
      Team (the Former Fuzhou General Hospital), Fujian Medical University, Fuzhou, 
      China.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Department of Oncology, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, China.
FAU - Tang, Chuanhao
AU  - Tang C
AD  - Department of Medical Oncology, Peking University International Hospital, 
      Beijing, China.
FAU - Zhou, Chengzhi
AU  - Zhou C
AUID- ORCID: 0000-0003-0029-6879
AD  - State Key Laboratory of Respiratory Disease, National Clinical Research Center 
      for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University (The First Affiliated 
      Hospital of Guangzhou Medical University), Guangzhou, China.
FAU - Zhang, Junping
AU  - Zhang J
AD  - Department of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi 
      Bethune Hospital, Taiyuan, China.
FAU - Guo, Hui
AU  - Guo H
AD  - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Chu, Qian
AU  - Chu Q
AD  - Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Meng, Rui
AU  - Meng R
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
FAU - Liu, Xuewen
AU  - Liu X
AD  - Department of Oncology, the Third Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Wu, Jingxun
AU  - Wu J
AD  - Department of Medical Oncology, the First Affiliated Hospital of Medicine, Xiamen 
      University, Xiamen, China.
FAU - Zhou, Jin
AU  - Zhou J
AD  - Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan 
      Cancer Center, School of Medicine, University of Electronic Science and 
      Technology, Chengdu, China.
FAU - Zhu, Zhengfei
AU  - Zhu Z
AD  - Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 
      Shanghai, China.
FAU - Pan, Weiwei
AU  - Pan W
AD  - Department of Cell Biology, College of Medicine, Jiaxing University, Jiaxing, 
      China.
FAU - Dong, Xiaowei
AU  - Dong X
AD  - Department of Medical, Shanghai OrigiMed Co., Ltd, Shanghai, China.
FAU - Pang, Fei
AU  - Pang F
AD  - Department of Medical, Shanghai OrigiMed Co., Ltd, Shanghai, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Medical, Shanghai OrigiMed Co., Ltd, Shanghai, China.
FAU - Yao, Chao
AU  - Yao C
AD  - Department of Medical, Shanghai OrigiMed Co., Ltd, Shanghai, China.
FAU - Lin, Guomin
AU  - Lin G
AD  - Department of Medical, Shanghai OrigiMed Co., Ltd, Shanghai, China.
FAU - Li, Site
AU  - Li S
AD  - Department of IVD Medical Marketing, 3D Medicines, Shanghai, China.
FAU - Yang, Zhi
AU  - Yang Z
AD  - Department of IVD Medical Marketing, 3D Medicines, Shanghai, China.
FAU - Luo, Jiancheng
AU  - Luo J
AD  - Department of Medical, Aiyi Technology, Beijing, China.
FAU - Jia, Hongtao
AU  - Jia H
AD  - Department of Medical, Aiyi Technology, Beijing, China.
FAU - Nie, Xiuqing
AU  - Nie X
AD  - Department of Clinical Trial, Novocodex Biopharmaceutic, Shaoxing, China.
FAU - Wang, Liping
AU  - Wang L
AD  - Department of Oncology, Baotou Cancer Hospital, Baotou, China.
FAU - Zhu, Youcai
AU  - Zhu Y
AD  - Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun 
      Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, China.
FAU - Hu, Xiao
AU  - Hu X
AD  - Zhejiang Key Laboratory of Radiation Oncology, Cancer Hospital of the University 
      of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
FAU - Xie, Yanru
AU  - Xie Y
AD  - Department of Oncology, Lishui Municipal Central Hospital, Lishui, China.
FAU - Lin, Xinqing
AU  - Lin X
AUID- ORCID: 0000-0001-9436-2229
AD  - State Key Laboratory of Respiratory Disease, National Clinical Research Center 
      for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University (The First Affiliated 
      Hospital of Guangzhou Medical University), Guangzhou, China.
FAU - Cai, Jing
AU  - Cai J
AUID- ORCID: 0000-0002-6792-4959
AD  - Department of Oncology, Second Affiliated Hospital of Nanchang University, 
      Nanchang, China.
FAU - Xia, Yang
AU  - Xia Y
AUID- ORCID: 0000-0003-2487-2244
AD  - Key Laboratory of Respiratory Disease of Zhejiang Province, Department of 
      Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang 
      University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, 
      China.
FAU - Feng, Huijing
AU  - Feng H
AD  - Department of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi 
      Bethune Hospital, Taiyuan, China.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Pathology, Shanxi Academy of Medical Sciences, Shanxi Bethune 
      Hospital, Taiyuan, China.
FAU - Du, Yingying
AU  - Du Y
AUID- ORCID: 0000-0002-5149-4632
AD  - Department of Oncology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Yao, Wang
AU  - Yao W
AD  - Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Shi, Xuefei
AU  - Shi X
AD  - Department of Respiratory Medicine, Huzhou Hospital, Zhejiang University School 
      of Medicine, Huzhou, China.
FAU - Niu, Xiaomin
AU  - Niu X
AD  - Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Yuan, Dongmei
AU  - Yuan D
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Yao, Yanwen
AU  - Yao Y
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Kang, Jing
AU  - Kang J
AD  - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational 
      Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, School of Medicine, Guangzhou, China.
FAU - Zhang, Jiatao
AU  - Zhang J
AD  - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational 
      Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, School of Medicine, Guangzhou, China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational 
      Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, School of Medicine, Guangzhou, China.
FAU - Gao, Wenbin
AU  - Gao W
AD  - Department of Oncology, The Third Affiliated Hospital of Shenzhen University, 
      Shenzhen, China.
FAU - Huang, Jianhui
AU  - Huang J
AD  - Department of Oncology, Lishui Municipal Central Hospital, Lishui, China.
FAU - Zhang, Yinbin
AU  - Zhang Y
AD  - Department of Oncology, the Second Affiliated Hospital of Medical College, Xi'an 
      Jiaotong University, Xi'an, China.
FAU - Sun, Pingli
AU  - Sun P
AD  - Department of Pathology, The Second Hospital of Jilin University, Changchun, 
      China.
FAU - Wang, Hong
AU  - Wang H
AD  - Senior Department of Oncology, The 5th Medical Center of PLA General Hospital, 
      Beijing, China.
FAU - Ye, Mingxiang
AU  - Ye M
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Wang, Zhaofeng
AU  - Wang Z
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Wan, Bing
AU  - Wan B
AD  - Department of Respiratory Medicine, The Affiliated Jiangning Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Lv, Donglai
AU  - Lv D
AUID- ORCID: 0000-0002-3816-6319
AD  - Department of Clinical Oncology, The 901 Hospital of Joint Logistics Support 
      Force of People Liberation Army, Hefei, China.
FAU - Yu, Genhua
AU  - Yu G
AD  - Department of Radiation Oncology, Zhebei Mingzhou Hospital, Huzhou, China.
FAU - Shi, Lin
AU  - Shi L
AD  - Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Xia, Yuanli
AU  - Xia Y
AD  - Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun 
      Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, China.
FAU - Gao, Feng
AU  - Gao F
AD  - Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Zhang, Xiaochen
AU  - Zhang X
AD  - Department of Oncology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Xu, Tao
AU  - Xu T
AD  - Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of 
      Qingdao University, Qingdao, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, 
      Hangzhou, China.
FAU - Wang, Haixia
AU  - Wang H
AD  - Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, 
      Hangzhou, China.
FAU - Liu, Zhefeng
AU  - Liu Z
AD  - Senior Department of Oncology, The 5th Medical Center of PLA General Hospital, 
      Beijing, China.
FAU - Yang, Nong
AU  - Yang N
AD  - Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan 
      Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, 
      Central South University, Changsha, China.
FAU - Wu, Lin
AU  - Wu L
AD  - Department of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The 
      Affiliated Cancer Hospital of Xiangya School of Medicine, Central South 
      University, Changsha, China.
FAU - Wang, Qiming
AU  - Wang Q
AD  - Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou 
      University, Henan Cancer Hospital, Zhengzhou, China.
FAU - Wang, Guansong
AU  - Wang G
AD  - Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical 
      University, Chongqing, China.
FAU - Hong, Zhuan
AU  - Hong Z
AD  - Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing Medical 
      University Affiliated Cancer Hospital, Nanjing, China.
FAU - Wang, Jiandong
AU  - Wang J
AD  - Department of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Fang, Meiyu
AU  - Fang M
AD  - Department of Chemotherapy, Chinese Academy of Sciences University Cancer 
      Hospital (Zhejiang Cancer Hospital), Hangzhou, China.
FAU - Fang, Yong
AU  - Fang Y
AD  - Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, 
      Hangzhou, China.
FAU - Zhang, Yiping
AU  - Zhang Y
AD  - Department of Chemotherapy, Chinese Academy of Sciences University Cancer 
      Hospital (Zhejiang Cancer Hospital), Hangzhou, China.
FAU - Song, Yong
AU  - Song Y
AUID- ORCID: 0000-0003-4979-4131
AD  - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Ma, Shenglin
AU  - Ma S
AD  - Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and 
      Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, 
      Cancer Center, Zhejiang University School of Medicine, Hangzhou, China.
FAU - Fang, Wenfeng
AU  - Fang W
AD  - Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer 
      Medicine, Guangzhou, China.
FAU - Lu, Yuanzhi
AU  - Lu Y
AUID- ORCID: 0000-0003-2946-643X
AD  - Department of Clinical Pathology, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20221128
PL  - Singapore
TA  - Thorac Cancer
JT  - Thoracic cancer
JID - 101531441
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Humans
MH  - *Carcinoma, Non-Small-Cell Lung/diagnosis/drug therapy/genetics
MH  - *Lung Neoplasms/diagnosis/drug therapy/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Consensus
MH  - East Asian People
MH  - *Antineoplastic Agents/therapeutic use
PMC - PMC9807451
OTO - NOTNLM
OT  - antibody-drug conjugate
OT  - non-small cell lung cancer
OT  - precision medicine
OT  - targeted therapy
OT  - tyrosine receptor kinase
EDAT- 2022/11/30 06:00
MHDA- 2023/01/05 06:00
PMCR- 2022/11/28
CRDT- 2022/11/29 01:32
PHST- 2022/11/03 00:00 [received]
PHST- 2022/11/07 00:00 [accepted]
PHST- 2022/11/30 06:00 [pubmed]
PHST- 2023/01/05 06:00 [medline]
PHST- 2022/11/29 01:32 [entrez]
PHST- 2022/11/28 00:00 [pmc-release]
AID - TCA14743 [pii]
AID - 10.1111/1759-7714.14743 [doi]
PST - ppublish
SO  - Thorac Cancer. 2023 Jan;14(1):91-104. doi: 10.1111/1759-7714.14743. Epub 2022 Nov 
      28.