PMID- 36445313
OWN - NLM
STAT- MEDLINE
DCOM- 20230621
LR  - 20230622
IS  - 2472-5625 (Electronic)
IS  - 2472-5625 (Linking)
VI  - 7
IP  - 2
DP  - 2023 Jun 19
TI  - Successful treatment of a patient with Takayasu's arteritis complicated with 
      Crohn's disease with ustekinumab: A case report.
PG  - 448-452
LID - 10.1093/mrcr/rxac090 [doi]
AB  - A 17-year-old woman was referred to our department with fever, general malaise, 
      and weight loss. She was diagnosed with Takayasu arteritis (TAK) and Crohn's 
      disease (CD) following positron emission tomography-computed tomography (PET-CT) 
      and colonoscopy, respectively. Serological human leukocyte antigen (HLA) typing 
      revealed HLA-B52 positivity. Initial treatment with prednisolone (PSL) 
      (0.5 mg/kg) was insufficient; therefore, ustekinumab and 5-aminosalicylic acid 
      were added. This treatment achieved PSL-free remission for both diseases, as 
      confirmed by PET-CT and colonoscopy. Although treatment guidelines for TAK and CD 
      have been previously established, treatment of patients with TAK with coexisting 
      CD is controversial. Our case suggests that ustekinumab has the ability to 
      achieve TAK remission in addition to its therapeutic effect on CD.
CI  - (c) Japan College of Rheumatology 2022. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Suga, Takeshi
AU  - Suga T
AD  - Division of Rheumatology, Kurume University Medical Center, Kurume, Japan.
AD  - Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, 
      Hiroshima, Japan.
FAU - Hidaka, Yukiko
AU  - Hidaka Y
AD  - Division of Rheumatology, Kurume University Medical Center, Kurume, Japan.
FAU - Hori, Maisa
AU  - Hori M
AD  - Division of Gastroenterology, Kurume University Medical Center, Kurume, Japan.
AD  - Naito Hospital, Kurume, Japan.
FAU - Yamasaki, Hiroshi
AU  - Yamasaki H
AD  - Division of Gastroenterology, Kurume University Medical Center, Kurume, Japan.
FAU - Wakasugi, Daisuke
AU  - Wakasugi D
AD  - Division of Rheumatology, Kurume University Medical Center, Kurume, Japan.
FAU - Yamasaki, Satoshi
AU  - Yamasaki S
AD  - Division of Rheumatology, Kurume University Medical Center, Kurume, Japan.
FAU - Yamaguchi, Rin
AU  - Yamaguchi R
AD  - Division of Pathology, Kurume University Medical Center, Kurume, Japan.
FAU - Ida, Hiroaki
AU  - Ida H
AD  - Division of Respirology, Neurology, and Rheumatology, Department of Medicine, 
      Kurume University School of Medicine, Kurume, Fukuoka, Japan.
FAU - Nakashima, Munetoshi
AU  - Nakashima M
AD  - Division of Rheumatology, Kurume University Medical Center, Kurume, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol Case Rep
JT  - Modern rheumatology case reports
JID - 101761026
RN  - FU77B4U5Z0 (Ustekinumab)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Female
MH  - Humans
MH  - Adolescent
MH  - *Crohn Disease/complications/diagnosis/drug therapy
MH  - *Takayasu Arteritis/complications/diagnosis/drug therapy
MH  - Ustekinumab/therapeutic use
MH  - Positron Emission Tomography Computed Tomography
MH  - Prednisolone/therapeutic use
OTO - NOTNLM
OT  - Crohn's diseases
OT  - IL12p40
OT  - PET-CT
OT  - Takayasu arteritis
OT  - ustekinumab
EDAT- 2022/11/30 06:00
MHDA- 2023/06/21 06:42
CRDT- 2022/11/29 10:43
PHST- 2022/07/19 00:00 [received]
PHST- 2022/10/05 00:00 [revised]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2023/06/21 06:42 [medline]
PHST- 2022/11/30 06:00 [pubmed]
PHST- 2022/11/29 10:43 [entrez]
AID - 6852714 [pii]
AID - 10.1093/mrcr/rxac090 [doi]
PST - ppublish
SO  - Mod Rheumatol Case Rep. 2023 Jun 19;7(2):448-452. doi: 10.1093/mrcr/rxac090.