PMID- 36446264
OWN - NLM
STAT- MEDLINE
DCOM- 20230303
LR  - 20230313
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 58
DP  - 2023 Mar-Apr
TI  - Survival after multiple episodes of cardiac arrest.
PG  - 98-103
LID - S0147-9563(22)00278-3 [pii]
LID - 10.1016/j.hrtlng.2022.11.011 [doi]
AB  - BACKGROUND: Cardiopulmonary resuscitation (CPR) is widely used in response to 
      cardiac arrest. However, little is known regarding outcomes for those who undergo 
      multiple episodes of cardiac arrest while in the hospital. OBJECTIVES: The 
      purpose of this study was to evaluate the association of multiple cardiac events 
      with in-hospital mortality for patients admitted to our tertiary care hospital 
      who underwent multiple code events. METHODS: We performed a retrospective cohort 
      study on all patients who underwent cardiac arrest from 2012 to 2016. Primary 
      outcome was survival to discharge. Secondary outcomes included 
      post-cardiac-arrest neurologic events (PCANE), non-home discharge, and one-year 
      mortality. RESULTS: There were 622 patients with an overall mortality rate of 
      78.0%. Patients undergoing CPR for cardiac arrest once during their admission had 
      lower in-hospital mortality rates compared to those that had multiple (68.9% 
      versus 91.3%, p<.01). Subset analysis of those who had multiple episodes of CPR 
      revealed that more than one event within a 24-hour period led to significantly 
      higher in-hospital mortality rates (94.7% versus 74.4%, p<.01). Other variables 
      associated with in-hospital mortality included body mass index, female sex, 
      malignancy, and increased down time per code. Patients that had a non-home 
      discharge were more likely to have sustained a PCANE than those that were 
      discharged home (31.4% versus 3.9%, p<.01). A non-home discharge was associated 
      with higher one-year mortality rates compared to a home discharge (78.4% versus 
      54.3%, p=.01). CONCLUSION: Multiple codes within a 24-hour period and the average 
      time per code were associated with in-hospital mortality in cardiac arrest 
      patients.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Jones, Bayley A
AU  - Jones BA
AD  - University of Texas, Southwestern Medical Center; Department of Surgery; Division 
      of Trauma and Acute Care Surgery; Dallas, TX.
FAU - Thornton, Micah A
AU  - Thornton MA
AD  - Southern Methodist University, Department of Statistical Science; Dallas, TX.
FAU - Heid, Christopher A
AU  - Heid CA
AD  - University of Texas, Southwestern; Department of Cardiothoracic Surgery; Division 
      of Cardiac Surgery; Dallas, TX.
FAU - Burke, Kristen L
AU  - Burke KL
AD  - University of Texas, Southwestern Medical Center; Department of Surgery; Division 
      of Trauma and Acute Care Surgery; Dallas, TX.
FAU - Scrushy, Marinda G
AU  - Scrushy MG
AD  - University of Texas, Southwestern Medical Center; Department of Surgery; Division 
      of Trauma and Acute Care Surgery; Dallas, TX.
FAU - Abdelfattah, Kareem R
AU  - Abdelfattah KR
AD  - University of Texas, Southwestern Medical Center; Department of Surgery; Division 
      of Trauma and Acute Care Surgery; Dallas, TX.
FAU - Wolf, Steven E
AU  - Wolf SE
AD  - University of Texas Medical Branch, Galveston; Department of Surgery; Division of 
      Trauma and Acute Care Surgery; Galveston, TX.
FAU - Khoury, Mitri K
AU  - Khoury MK
AD  - University of Texas, Southwestern Medical Center; Department of Surgery; Division 
      of Trauma and Acute Care Surgery; Dallas, TX; Massachusetts General Hospital; 
      Department of Surgery; Division of Vascular and Endovascular Surgery; Boston, MA. 
      Electronic address: mitri.khoury@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20221126
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
SB  - IM
MH  - Humans
MH  - Female
MH  - *Cardiopulmonary Resuscitation
MH  - Retrospective Studies
MH  - *Heart Arrest
MH  - Hospitalization
MH  - Patient Discharge
MH  - Treatment Outcome
MH  - Survival Rate
MH  - *Out-of-Hospital Cardiac Arrest
OTO - NOTNLM
OT  - ACLS
OT  - CPR
OT  - Cardiac arrest
OT  - Critical care
OT  - Mortality
OT  - None-home discharge
OT  - Resuscitation
OT  - Stroke
OT  - hospital
COIS- Declaration of Competing Interest The authors report no proprietary or commercial 
      interest in any product or concept discussed in this article.
EDAT- 2022/11/30 06:00
MHDA- 2023/03/04 06:00
CRDT- 2022/11/29 18:19
PHST- 2022/06/13 00:00 [received]
PHST- 2022/11/18 00:00 [revised]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/11/30 06:00 [pubmed]
PHST- 2023/03/04 06:00 [medline]
PHST- 2022/11/29 18:19 [entrez]
AID - S0147-9563(22)00278-3 [pii]
AID - 10.1016/j.hrtlng.2022.11.011 [doi]
PST - ppublish
SO  - Heart Lung. 2023 Mar-Apr;58:98-103. doi: 10.1016/j.hrtlng.2022.11.011. Epub 2022 
      Nov 26.