PMID- 36447529
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221202
IS  - 2578-9430 (Electronic)
IS  - 2578-9430 (Linking)
VI  - 2022
DP  - 2022
TI  - CRISPR-Induced Loss of Connexin 43 Expression Sensitizes KRAS Mutant Cells to 
      Cisplatin.
LID - 10.17912/micropub.biology.000681 [doi]
AB  - Gap Junction intercellular communication (GJIC) is often dysregulated in cancers, 
      and this dysregulation has been shown to have pro-tumorigenic effects. Connexins 
      (Cxs) are transmembrane proteins that make up gap junctions. Previous studies 
      have indicated that RNA interference (RNAi)-based suppression of Cx43 increases 
      cellular resistance to the chemotherapeutic agent cisplatin. Interestingly, we 
      found that the loss of Cx43 expression induced by the CRISPR-Cas9 technology 
      sensitizes cells to cisplatin in a KRAS mutant-dependent manner.
CI  - Copyright: (c) 2022 by the authors.
FAU - Martin, Stephen
AU  - Martin S
AD  - Eastern Virginia Medical School.
FAU - Mu, David
AU  - Mu D
AD  - Eastern Virginia Medical School.
LA  - eng
PT  - Journal Article
DEP - 20221113
PL  - United States
TA  - MicroPubl Biol
JT  - microPublication biology
JID - 101759238
PMC - PMC9701319
EDAT- 2022/12/01 06:00
MHDA- 2022/12/01 06:01
PMCR- 2022/11/13
CRDT- 2022/11/30 01:54
PHST- 2022/09/30 00:00 [received]
PHST- 2022/11/07 00:00 [revised]
PHST- 2022/11/10 00:00 [accepted]
PHST- 2022/11/30 01:54 [entrez]
PHST- 2022/12/01 06:00 [pubmed]
PHST- 2022/12/01 06:01 [medline]
PHST- 2022/11/13 00:00 [pmc-release]
AID - 10.17912/micropub.biology.000681 [doi]
PST - epublish
SO  - MicroPubl Biol. 2022 Nov 13;2022:10.17912/micropub.biology.000681. doi: 
      10.17912/micropub.biology.000681. eCollection 2022.