PMID- 36447989
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221202
IS  - 2251-6093 (Electronic)
IS  - 2251-6085 (Print)
IS  - 2251-6085 (Linking)
VI  - 51
IP  - 6
DP  - 2022 Jun
TI  - Effect of Dapagliflozin Combined with Cognitive Behavior Training on Quality of 
      Life and Cognitive Function in Elderly Patients with Type 2 Diabetes Mellitus 
      Complicated with Mild Cognitive Impairment.
PG  - 1251-1258
LID - 10.18502/ijph.v51i6.9668 [doi]
AB  - BACKGROUND: To investigate the effect of dapagliflozin combined with cognitive 
      behavior training on quality of life and cognitive function in elderly patients 
      with type 2 diabetes mellitus (T2DM) complicated with mild cognitive impairment. 
      METHODS: Ninety-six elderly patients with T2DM and mild cognitive impairment 
      treated in Shenzhen People's Hospital, Guangdong Province China from June 2019 to 
      December 2020 were selected and equally randomized into control group (CG) and 
      experimental group (EG). The CG received conventional intervention, while the EG 
      received dapagliflozin combined with cognitive behavior training based on the CG. 
      The clinical observation indexes of both groups were compared to assess the 
      clinical intervention effect of dapagliflozin combined with cognitive behavior 
      training on elderly patients with T2DM complicated with mild cognitive 
      impairment. RESULTS: After intervention, the blood glucose levels of both groups 
      decreased, and compared with the CG, the blood glucose level of the EG was 
      markedly lower (P<0.05). The scores of C-DMSES, ADL and MMSE of both groups were 
      higher than those before intervention, and compared with the CG, the scores of 
      the EG were obviously higher (P<0.05). The QOL-AD scores of both groups gradually 
      increased, and compared with the CG, the QOL-AD scores of the EG were higher at 3 
      and 6 months after intervention (P<0.05). CONCLUSION: For elderly patients with 
      T2DM complicated with mild cognitive impairment, dapagliflozin combined with 
      cognitive behavior training intervention can obviously improve their cognitive 
      function, self-efficacy of diabetes management and quality of life, which should 
      be promoted in clinic.
CI  - Copyright (c) 2022 Zhao et al. Published by Tehran University of Medical Sciences.
FAU - Zhao, Ying
AU  - Zhao Y
AD  - Department of Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical 
      College, Jinan University; The First Affiliated Hospital, Southern University of 
      Science and Technology), Shenzhen, 518020, Guangdong Province, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Department of Endocrinology, Shenzhen People's Hospital (The Second Clinical 
      Medical College, Jinan University; The First Affiliated Hospital, Southern 
      University of Science and Technology), Shenzhen 518020, Guangdong, China.
FAU - Wang, Su
AU  - Wang S
AD  - Department of Cardiovascular and Thoracic Surgery, The 305 Hospital, Beijing 
      100000, China.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Public Health
JT  - Iranian journal of public health
JID - 7505531
PMC - PMC9659529
OTO - NOTNLM
OT  - Cognitive behavior training
OT  - Dapagliflozin
OT  - Elders
OT  - Type 2 diabetes mellitus
COIS- Conflict of interest The authors declare that there is no conflict of interest.
EDAT- 2022/12/01 06:00
MHDA- 2022/12/01 06:01
PMCR- 2022/06/01
CRDT- 2022/11/30 02:02
PHST- 2021/08/15 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2022/11/30 02:02 [entrez]
PHST- 2022/12/01 06:00 [pubmed]
PHST- 2022/12/01 06:01 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - IJPH-51-1251 [pii]
AID - 10.18502/ijph.v51i6.9668 [doi]
PST - ppublish
SO  - Iran J Public Health. 2022 Jun;51(6):1251-1258. doi: 10.18502/ijph.v51i6.9668.