PMID- 36448244
OWN - NLM
STAT- MEDLINE
DCOM- 20230330
LR  - 20230919
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 10
IP  - 2
DP  - 2023 Apr
TI  - Deformation Imaging by Strain in Chronic Heart Failure Over Sacubitril-Valsartan: 
      A Multicenter Echocardiographic Registry.
PG  - 846-857
LID - 10.1002/ehf2.14155 [doi]
AB  - AIMS: Sacubitril/valsartan has changed the treatment of heart failure with 
      reduced ejection fraction (HFrEF), due to the positive effects on morbidity and 
      mortality, partly mediated by left ventricular (LV) reverse remodelling (LVRR). 
      The aim of this multicenter study was to identify echocardiographic predictors of 
      LVRR after sacubitril/valsartan administration. METHODS AND RESULTS: Patients 
      with HFrEF requiring therapy with sacubitril/valsartan from 13 Italian centres 
      were included. Echocardiographic parameters including LV global longitudinal 
      strain (GLS) and global peak atrial longitudinal strain by speckle tracking 
      echocardiography were measured to find the predictors of LVRR [= LV end-systolic 
      volume reduction >/=10% and ejection fraction (LVEF) improvement >/=10% at follow-up] 
      at 6 month follow-up as the primary endpoint. Changes in symptoms [New York Heart 
      Association (NYHA) class] and neurohormonal activations [N-terminal pro-brain 
      natriuretic peptide (NT-proBNP)] were also evaluated as secondary endpoints; 341 
      patients (excluding patients with poor acoustic windows and missing data) were 
      analysed (mean age: 65 +/- 10 years; 18% female, median LVEF 30% [inter-quartile 
      range: 25-34]). At 6 month follow-up, 82 (24%) patients showed early complete 
      response (LVRR and LVEF >/= 35%), 55 (16%) early incomplete response (LVRR and 
      LVEF < 35%), and 204 (60%) no response (no LVRR and LVEF < 35%). Non-ischaemic 
      aetiology, a lower left atrial volume index, and a higher GLS were all 
      independent predictors of LVRR at multivariable logistic analysis (all P < 0.01). 
      A baseline GLS < -9.3% was significantly associated with early response (area 
      under the curve 0.75, P < 0.0001). Left atrial strain was the best predictor of 
      positive changes in NYHA class and NT-proBNP (all P < 0.05). CONCLUSIONS: Speckle 
      tracking echocardiography parameters at baseline could be useful to predict LVRR 
      and clinical response to sacubitril-valsartan and could be used as a guide for 
      treatment in patients with HFrEF.
CI  - (c) 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on 
      behalf of European Society of Cardiology.
FAU - Mandoli, Giulia Elena
AU  - Mandoli GE
AD  - Division of Cardiology, Department of Medical Biotechnologies, University of 
      Siena, Viale Bracci 1, Siena, Italy.
FAU - Pastore, Maria Concetta
AU  - Pastore MC
AUID- ORCID: 0000-0002-7223-141X
AD  - Division of Cardiology, Department of Medical Biotechnologies, University of 
      Siena, Viale Bracci 1, Siena, Italy.
FAU - Giannoni, Alberto
AU  - Giannoni A
AD  - Cardiology and Cardiovascular Medicine Department, Fondazione Toscana G. 
      Monasterio, Pisa, Italy.
AD  - Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
FAU - Benfari, Giovanni
AU  - Benfari G
AD  - Section of Cardiology, Department of Medicine, University of Verona, Verona, 
      Italy.
FAU - Dini, Frank Lloyd
AU  - Dini FL
AD  - Centro Medico Santagostino, Milan, Italy.
FAU - Rosa, Gianmarco
AU  - Rosa G
AD  - Department of Internal Medicine and Medical Specialities, University of Genoa, 
      Genoa, Italy.
FAU - Pugliese, Nicola Riccardo
AU  - Pugliese NR
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Taddei, Claudia
AU  - Taddei C
AD  - Cardiology and Cardiovascular Medicine Department, Fondazione Toscana G. 
      Monasterio, Pisa, Italy.
FAU - Correale, Michele
AU  - Correale M
AD  - Cardiology Department, Policlinico Riuniti University Hospital, Foggia, Italy.
FAU - Brunetti, Natale Daniele
AU  - Brunetti ND
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Mazzeo, Pietro
AU  - Mazzeo P
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Carluccio, Erberto
AU  - Carluccio E
AD  - Cardiology and Cardiovascular Pathophysiology-Heart Failure Unit, 'Santa Maria 
      della Misericordia' Hospital, University of Perugia, Perugia, Italy.
FAU - Mengoni, Anna
AU  - Mengoni A
AD  - Cardiology and Cardiovascular Pathophysiology-Heart Failure Unit, 'Santa Maria 
      della Misericordia' Hospital, University of Perugia, Perugia, Italy.
FAU - Guaricci, Andrea Igoren
AU  - Guaricci AI
AD  - University Cardiology Unit, Cardiothoracic Department, Polyclinic University 
      Hospital, Bari, Italy.
FAU - Piscitelli, Laura
AU  - Piscitelli L
AD  - University Cardiology Unit, Cardiothoracic Department, Polyclinic University 
      Hospital, Bari, Italy.
FAU - Citro, Rodolfo
AU  - Citro R
AD  - Cardio-Thoracic-Vascular Department, University Hospital San Giovanni di Dio e 
      Ruggi d'Aragona, Salerno, Italy.
FAU - Ciccarelli, Michele
AU  - Ciccarelli M
AD  - Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 
      Italy.
FAU - Novo, Giuseppina
AU  - Novo G
AD  - Division of Cardiology, Department of Health Promotion, Mother and Child Care, 
      Internal Medicine and Medical Specialties (ProMISE), University Hospital Paolo 
      Giaccone, University of Palermo, Palermo, Italy.
FAU - Corrado, Egle
AU  - Corrado E
AD  - Division of Cardiology, Department of Health Promotion, Mother and Child Care, 
      Internal Medicine and Medical Specialties (ProMISE), University Hospital Paolo 
      Giaccone, University of Palermo, Palermo, Italy.
FAU - Pasquini, Annalisa
AU  - Pasquini A
AD  - Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico 
      Universitario A. Gemelli, IRCCS, Universita Cattolica del Sacro Cuore, Rome, 
      Italy.
FAU - Loria, Valentina
AU  - Loria V
AD  - Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico 
      Universitario A. Gemelli, IRCCS, Universita Cattolica del Sacro Cuore, Rome, 
      Italy.
FAU - De Carli, Giuseppe
AU  - De Carli G
AD  - Division of Cardiology, Department of Medical Biotechnologies, University of 
      Siena, Viale Bracci 1, Siena, Italy.
FAU - Degiovanni, Anna
AU  - Degiovanni A
AD  - Department of Thoracic, Heart and Vascular Diseases, Maggiore della Carita 
      Hospital, Novara, Italy.
FAU - Patti, Giuseppe
AU  - Patti G
AD  - Department of Thoracic, Heart and Vascular Diseases, Maggiore della Carita 
      Hospital, Novara, Italy.
AD  - Department of Translational Medicine, University of Piemonte Orientale, Novara, 
      Italy.
FAU - Santoro, Ciro
AU  - Santoro C
AD  - Department of Advanced Biomedical Science, Federico II University Hospital, 
      Naples, Italy.
FAU - Moderato, Luca
AU  - Moderato L
AD  - Cardiology Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.
FAU - Cicoira, Mariantonietta
AU  - Cicoira M
AD  - Section of Cardiology, Department of Medicine, University of Verona, Verona, 
      Italy.
FAU - Canepa, Marco
AU  - Canepa M
AD  - Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, IRCCS 
      Italian Cardiovascular Network, Genoa, Italy.
AD  - Department of Internal Medicine, University of Genoa, Genoa, Italy.
FAU - Malagoli, Alessandro
AU  - Malagoli A
AD  - Division of Cardiology, Nephro-Cardiovascular Department, Baggiovara Hospital, 
      University of Modena and Reggio Emilia, Modena, Italy.
FAU - Emdin, Michele
AU  - Emdin M
AD  - Cardiology and Cardiovascular Medicine Department, Fondazione Toscana G. 
      Monasterio, Pisa, Italy.
AD  - Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
FAU - Cameli, Matteo
AU  - Cameli M
AD  - Division of Cardiology, Department of Medical Biotechnologies, University of 
      Siena, Viale Bracci 1, Siena, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20221129
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
RN  - WB8FT61183 (sacubitril and valsartan sodium hydrate drug combination)
RN  - 17ERJ0MKGI (sacubitril)
RN  - 0 (Tetrazoles)
RN  - 80M03YXJ7I (Valsartan)
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Aged
MH  - Male
MH  - *Heart Failure/diagnostic imaging/drug therapy
MH  - *Atrial Fibrillation/drug therapy
MH  - Tetrazoles/therapeutic use
MH  - Stroke Volume
MH  - Valsartan/therapeutic use
MH  - Echocardiography/methods
MH  - *Ventricular Dysfunction, Left
PMC - PMC10053272
OTO - NOTNLM
OT  - Biomarkers
OT  - Cardiovascular disease
OT  - Echocardiography
OT  - Heart failure
OT  - Imaging
OT  - Remodelling
OT  - Sacubitril/valsartan
OT  - Speckle tracking
OT  - Ultrasound
COIS- None declared.
EDAT- 2022/12/01 06:00
MHDA- 2023/03/30 06:11
PMCR- 2022/11/29
CRDT- 2022/11/30 02:53
PHST- 2022/09/01 00:00 [revised]
PHST- 2021/12/26 00:00 [received]
PHST- 2022/09/08 00:00 [accepted]
PHST- 2023/03/30 06:11 [medline]
PHST- 2022/12/01 06:00 [pubmed]
PHST- 2022/11/30 02:53 [entrez]
PHST- 2022/11/29 00:00 [pmc-release]
AID - EHF214155 [pii]
AID - 10.1002/ehf2.14155 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2023 Apr;10(2):846-857. doi: 10.1002/ehf2.14155. Epub 2022 Nov 
      29.