PMID- 36450965
OWN - NLM
STAT- MEDLINE
DCOM- 20230310
LR  - 20230310
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 11
DP  - 2023 Mar
TI  - Association between mixed aldehydes and bone mineral density based on four 
      statistical models.
PG  - 31631-31646
LID - 10.1007/s11356-022-24373-y [doi]
AB  - Aldehydes as an environmental pollutant may lead to oxidative stress, which is an 
      important mechanism in the development of osteoporosis. This suggests a possible 
      link between aldehyde exposure and osteoporosis. Considering the mixed nature of 
      aldehyde exposure and the interactions between different aldehydes, we explored 
      for the first time the associations between mixed six aldehydes (benzaldehyde, 
      butyraldehyde, heptanal, hexanal, isovaleraldehyde, and propionaldehyde) and BMD 
      in three populations (men, premenopausal women, and postmenopausal women) by 
      applying four statistical models: quantile g-computation (qgcomp) model, Bayesian 
      kernel machine regression (BKMR) model, generalized linear regression model 
      (GLM), and generalized additive model (GAM), based on the National Health and 
      Nutrition Examination Survey (NHANES) 2013-2014. We found that mixed aldehydes 
      could significantly reduce BMD in men, with hexanaldehyde and propanaldehyde 
      having the greatest negative qgcomp model and BKMR model weights, also confirmed 
      by GLM. The associations between isopentanaldehyde and propanaldehyde and femoral 
      BMD in men were non-linear and had threshold effects as derived from the BKMR 
      model and GAM. The associations turned positive when the concentrations of 
      isopentanaldehyde and propanaldehyde exceeded their respective inflection points. 
      To conclude, our study might provide new ideas for the prevention and treatment 
      of osteoporosis, and hexanaldehyde and propanaldehyde should be more regulated to 
      prevent osteoporosis.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Gu, Lanxin
AU  - Gu L
AD  - Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing 
      Medical University, Nanjing, 210029, China.
AD  - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029, China.
AD  - Jiangsu Province Engineering Research Center of Stomatological Translational 
      Medicine, Nanjing, 210029, China.
FAU - Wang, Zhongyuan
AU  - Wang Z
AD  - Department of Urology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, 210029, China.
FAU - Liu, Luwei
AU  - Liu L
AD  - Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing 
      Medical University, Nanjing, 210029, China.
AD  - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029, China.
AD  - Jiangsu Province Engineering Research Center of Stomatological Translational 
      Medicine, Nanjing, 210029, China.
FAU - Luo, Jiayi
AU  - Luo J
AD  - State Key Laboratory of Pollution Control and Resource Reuse, School of the 
      Environment, Nanjing University, Nanjing, 210023, China.
FAU - Pan, Yang
AU  - Pan Y
AD  - State Key Laboratory of Pollution Control and Resource Reuse, School of the 
      Environment, Nanjing University, Nanjing, 210023, China.
FAU - Sun, Lian
AU  - Sun L
AD  - Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing 
      Medical University, Nanjing, 210029, China.
AD  - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029, China.
AD  - Jiangsu Province Engineering Research Center of Stomatological Translational 
      Medicine, Nanjing, 210029, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing 
      Medical University, Nanjing, 210029, China.
AD  - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029, China.
AD  - Jiangsu Province Engineering Research Center of Stomatological Translational 
      Medicine, Nanjing, 210029, China.
FAU - Zhang, Wei-Bing
AU  - Zhang WB
AD  - Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing 
      Medical University, Nanjing, 210029, China. wbzhang@suda.edu.cn.
AD  - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, 210029, China. 
      wbzhang@suda.edu.cn.
AD  - Jiangsu Province Engineering Research Center of Stomatological Translational 
      Medicine, Nanjing, 210029, China. wbzhang@suda.edu.cn.
AD  - Department of Stomatology, Dushu Lake Hospital Affiliated to Soochow University, 
      Suzhou, China. wbzhang@suda.edu.cn.
AD  - Department of Stomatology, Medical Center of Soochow University, Suzhou, China. 
      wbzhang@suda.edu.cn.
AD  - Department of Stomatology, Suzhou Dushu Lake Hospital, Suzhou, China. 
      wbzhang@suda.edu.cn.
LA  - eng
GR  - 81870797/National Natural Science Foundation of China/
GR  - PAPD 2018-87/Priority Academic Program Development of Jiangsu Higher Education 
      Institutions/
PT  - Journal Article
DEP - 20221201
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 9DC2K31JJQ (n-hexanal)
RN  - 0 (Aldehydes)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Bone Density
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Models, Statistical
MH  - Aldehydes
MH  - *Osteoporosis
OTO - NOTNLM
OT  - Aldehyde
OT  - BKMR
OT  - BMD
OT  - Joint effect
OT  - NHANES
EDAT- 2022/12/01 06:00
MHDA- 2023/03/11 06:00
CRDT- 2022/11/30 23:45
PHST- 2022/08/05 00:00 [received]
PHST- 2022/11/18 00:00 [accepted]
PHST- 2022/12/01 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2022/11/30 23:45 [entrez]
AID - 10.1007/s11356-022-24373-y [pii]
AID - 10.1007/s11356-022-24373-y [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Mar;30(11):31631-31646. doi: 
      10.1007/s11356-022-24373-y. Epub 2022 Dec 1.