PMID- 36451205
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20221213
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Nov 30
TI  - Minimal clinically important difference for the Mandarin version of the Tinnitus 
      Questionnaire determined via anchor-based and distribution-based methods.
PG  - 157
LID - 10.1186/s12955-022-02072-z [doi]
LID - 157
AB  - BACKGROUND: The previous study showed that the Mandarin Tinnitus Questionnaire 
      (MTQ) has satisfactory reliability and validity. We have also completed the 
      classification of the severity of tinnitus based on MTQ scores. In clinical 
      studies, efficacy is often judged by whether results are statistically 
      significant; however, statistical significance does not necessarily equate to 
      clinical significance, whereas the minimum clinically important difference (MCID) 
      of the scale does. In the following project, we will explore the MCID of the MTQ. 
      METHODS: We recruited participants aged 18 years and above who sought treatment 
      for primary or secondary tinnitus at the Otorhinolaryngology Department of the 
      Hearing Center of West China Hospital, Sichuan University from September 2020 to 
      September 2021. The participants had to undergo the following four assessments of 
      tinnitus severity: doctor evaluation, self-report, the MTQ, and the visual analog 
      scale (VAS), all at baseline and at the follow-up. The MCIDs of the MTQ were 
      established via anchor-based and distribution-based methods. The anchor method 
      used the VAS and self-reported clinical impression as anchors and defined the 
      treatment effectiveness by mean/median and receiver operating characteristic 
      (ROC) curve, while methods of effect size (ES), standard error of measurement 
      (SEM), and reliability change index (RCI) were used in distribution-based 
      methods. RESULTS: A total of 115 patients were investigated in this study, 57.4% 
      of whom were women. The average age was 43.2 +/- 13.20 years. The average MTQ and 
      VAS scores at baseline were 31.3 +/- 14.90 and 5.03 +/- 2.24, respectively, while the 
      average MTQ and VAS scores at follow-up were 15.9 +/- 11.70 and 3.58 +/- 2.48, 
      respectively. Moreover, in terms of self-reported clinical impressions, 19 
      patients indicated that they were cured (16.5%), 24 that it was much better 
      (20.9%), 63 that there was no change (54.8%), and 9 that it was much worse 
      (7.8%). The MCIDs for the change in total MTQ ranged from 6.29 to 19.00, those 
      for improvement from 1.09 to 22.75, and those for deterioration from 3.50 to 
      7.64. CONCLUSION: We selected an absolute value of 7.5 as the MCID for the MTQ 
      score. An increase in MTQ score more than 7.5 was considered aggravation of 
      tinnitus, and a decrease in MTQ score more than 7.5 was considered a reduction in 
      tinnitus.
CI  - (c) 2022. The Author(s).
FAU - Gu, Hailing
AU  - Gu H
AD  - Department of Otolaryngology-Head and Neck Surgery, Hearing Center/Hearing and 
      Speech Science Laboratory, West China Hospital of Sichuan University, 37 Guo Xue 
      Lane, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Diao, Cong
AU  - Diao C
AD  - Department of Otolaryngology-Head and Neck Surgery, Hearing Center/Hearing and 
      Speech Science Laboratory, West China Hospital of Sichuan University, 37 Guo Xue 
      Lane, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Tang, Jiatong
AU  - Tang J
AD  - West China Hospital/West China Medical School, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Yang, Bo
AU  - Yang B
AD  - West China Hospital/West China Medical School, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Ji, Jinfeng
AU  - Ji J
AD  - Department of Otolaryngology-Head and Neck Surgery, Hearing Center/Hearing and 
      Speech Science Laboratory, West China Hospital of Sichuan University, 37 Guo Xue 
      Lane, Chengdu, 610041, Sichuan, People's Republic of China.
FAU - Zhou, Mengyun
AU  - Zhou M
AD  - West China Hospital/West China Medical School, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Meng, Zhaoli
AU  - Meng Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Hearing Center/Hearing and 
      Speech Science Laboratory, West China Hospital of Sichuan University, 37 Guo Xue 
      Lane, Chengdu, 610041, Sichuan, People's Republic of China. 
      lucy-mengzhaoli@163.com.
LA  - eng
PT  - Journal Article
DEP - 20221130
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Humans
MH  - Female
MH  - Adult
MH  - Middle Aged
MH  - Male
MH  - *Minimal Clinically Important Difference
MH  - *Tinnitus/diagnosis
MH  - Reproducibility of Results
MH  - Quality of Life
MH  - Self Report
PMC - PMC9710156
OTO - NOTNLM
OT  - Mandarin Tinnitus Questionnaire (MTQ)
OT  - Minimal clinically important difference (MCID)
OT  - Tinnitus
COIS- The authors declare that they have no competing interests.
EDAT- 2022/12/02 06:00
MHDA- 2022/12/03 06:00
PMCR- 2022/11/30
CRDT- 2022/12/01 00:01
PHST- 2022/08/13 00:00 [received]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/12/01 00:01 [entrez]
PHST- 2022/12/02 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/11/30 00:00 [pmc-release]
AID - 10.1186/s12955-022-02072-z [pii]
AID - 2072 [pii]
AID - 10.1186/s12955-022-02072-z [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2022 Nov 30;20(1):157. doi: 
      10.1186/s12955-022-02072-z.