PMID- 36452016
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221202
IS  - 2233-8276 (Print)
IS  - 2233-8268 (Electronic)
IS  - 2233-8276 (Linking)
VI  - 12
IP  - 4
DP  - 2022 Oct
TI  - Mechanisms and biomarkers of successful allergen-specific immunotherapy.
PG  - e45
LID - 10.5415/apallergy.2022.12.e45 [doi]
LID - e45
AB  - Allergen-specific immunotherapy (AIT) is considered the only curative treatment 
      for allergic diseases mediated by immunoglobulin E (IgE). Currently, the route of 
      administration depends both on the different types of causal allergens and on its 
      effectiveness and safety profile. Several studies have reported the mechanisms 
      and changes in humoral and cellular response underlying AIT; however, the full 
      picture remains unknown. Knowledge of who can benefit from this type of treatment 
      is urgently needed due to the patient safety risks and costs of AIT. In vivo or 
      in vitro biomarkers have become a strategy to predict clinical outcomes in 
      precision medicine. There are currently no standardized biomarkers that allow 
      determining successful responses to AIT, however, some studies have found 
      differences between responders and nonresponders. In addition, different 
      candidates have been postulated that may have the potential to become biomarkers. 
      In this review, we aim to summarize the findings to date related to biomarkers in 
      different IgE-mediated allergic diseases (respiratory, food, and venom allergy) 
      with the potential to define who will benefit from AIT.
CI  - Copyright (c) 2022. Asia Pacific Association of Allergy, Asthma and Clinical 
      Immunology.
FAU - Lopez, Juan-Felipe
AU  - Lopez JF
AUID- ORCID: 0000-0002-9993-9530
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - Bel Imam, Manal
AU  - Bel Imam M
AUID- ORCID: 0000-0002-7352-7204
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - Satitsuksanoa, Pattraporn
AU  - Satitsuksanoa P
AUID- ORCID: 0000-0001-9540-7759
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - Lems, Sophieke
AU  - Lems S
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - Yang, Minglin
AU  - Yang M
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - Hwang, Yu-Kyoung
AU  - Hwang YK
AUID- ORCID: 0000-0002-8025-7134
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Losol, Purevsuren
AU  - Losol P
AUID- ORCID: 0000-0001-7620-1077
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
AD  - Institute of Allergy and Clinical Immunology, Seoul National University Medical 
      Research Center, Seoul National University, Seoul, Korea.
FAU - Choi, Jun-Pyo
AU  - Choi JP
AUID- ORCID: 0000-0001-8925-1786
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
FAU - Kim, Sae-Hoon
AU  - Kim SH
AUID- ORCID: 0000-0002-2572-5302
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
AD  - Institute of Allergy and Clinical Immunology, Seoul National University Medical 
      Research Center, Seoul National University, Seoul, Korea.
FAU - Chang, Yoon-Seok
AU  - Chang YS
AUID- ORCID: 0000-0003-3157-0447
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, Korea.
AD  - Institute of Allergy and Clinical Immunology, Seoul National University Medical 
      Research Center, Seoul National University, Seoul, Korea.
FAU - Akdis, Mubeccel
AU  - Akdis M
AUID- ORCID: 0000-0003-0554-9943
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - Akdis, Cezmi A
AU  - Akdis CA
AUID- ORCID: 0000-0001-8020-019X
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
FAU - van de Veen, Willem
AU  - van de Veen W
AUID- ORCID: 0000-0001-9951-6688
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      Davos, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221031
PL  - Netherlands
TA  - Asia Pac Allergy
JT  - Asia Pacific allergy
JID - 101561954
PMC - PMC9669467
OTO - NOTNLM
OT  - Allergen-specific immunotherapy
OT  - Allergy
OT  - Biomarkers
OT  - IgE
OT  - Regulatory T cells
OT  - regulatory B cells
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2022/12/02 06:00
MHDA- 2022/12/02 06:01
PMCR- 2022/10/01
CRDT- 2022/12/01 02:34
PHST- 2022/10/29 00:00 [received]
PHST- 2022/10/30 00:00 [accepted]
PHST- 2022/12/01 02:34 [entrez]
PHST- 2022/12/02 06:00 [pubmed]
PHST- 2022/12/02 06:01 [medline]
PHST- 2022/10/01 00:00 [pmc-release]
AID - 10.5415/apallergy.2022.12.e45 [doi]
PST - epublish
SO  - Asia Pac Allergy. 2022 Oct 31;12(4):e45. doi: 10.5415/apallergy.2022.12.e45. 
      eCollection 2022 Oct.